Non-Insulin-Dependent Diabetes Mellitus disease length
Item
type 2 diabetes mellitus of less than 5 years in duration
boolean
C0011860 (UMLS CUI [1,1])
C0872146 (UMLS CUI [1,2])
Hypoglycemia untreated
Item
have never received hypoglycemic therapy
boolean
C0020615 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
Age
Item
aged 18 to 65 years
boolean
C0001779 (UMLS CUI [1])
Fasting blood glucose measurement Cohort Roman letter
Item
fasting blood glucose between 130 and 220 mg/dl (7.2 to 12.2 mmol/l) for cohorts a-d and between 140 and 220 mg/dl (7.8 to 12.2 mmol/l) for cohort e
boolean
C0428568 (UMLS CUI [1,1])
C0599755 (UMLS CUI [1,2])
C0439102 (UMLS CUI [1,3])
Glucohemoglobin measurement Cohort Roman letter
Item
hba1c between 6.8 and 10.0% for cohorts a-d and between 7.5 and 11.0% for cohort e
boolean
C0202054 (UMLS CUI [1,1])
C0599755 (UMLS CUI [1,2])
C0439102 (UMLS CUI [1,3])
Body mass index
Item
body mass index > 25 and < 35 kg m -2
boolean
C1305855 (UMLS CUI [1])
Pharmaceutical Preparations Affecting Glucose homeostasis | Glucocorticoids Systemic
Item
medication that may affect glucose homeostasis (e.g. systemic glucocorticoid) within one month of screening
boolean
C0013227 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C1326961 (UMLS CUI [1,3])
C0017710 (UMLS CUI [2,1])
C0205373 (UMLS CUI [2,2])
Medical History Abnormality Clinical Significance | Physical examination abnormal Clinical Significance
Item
clinically significant abnormalities in medical history or physical exam
boolean
C0262926 (UMLS CUI [1,1])
C1704258 (UMLS CUI [1,2])
C2826293 (UMLS CUI [1,3])
C0747585 (UMLS CUI [2,1])
C2826293 (UMLS CUI [2,2])
Laboratory examination Abnormality Clinical Significance
Item
clinically significant abnormalities on laboratory examination
boolean
C0260877 (UMLS CUI [1,1])
C1704258 (UMLS CUI [1,2])
C2826293 (UMLS CUI [1,3])
HIV Infection
Item
history of hiv infection
boolean
C0019693 (UMLS CUI [1])
Communicable Disease Requirement Antiviral Therapy | Communicable Disease Requirement Therapeutic procedure Antimicrobial medicament
Item
active infection requiring antiviral or antimicrobial therapy
boolean
C0009450 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0280274 (UMLS CUI [1,3])
C0009450 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0087111 (UMLS CUI [2,3])
C0443071 (UMLS CUI [2,4])
Malignant Neoplasms | Basal cell carcinoma Treated Adequate | Squamous cell carcinoma of skin Treated Adequate
Item
malignancy (with the exception of basal or squamous cell carcinoma of the skin if adequately treated and no recurrence for > one year at the time of screening)
boolean
C0006826 (UMLS CUI [1])
C0007117 (UMLS CUI [2,1])
C1522326 (UMLS CUI [2,2])
C0205411 (UMLS CUI [2,3])
C0553723 (UMLS CUI [3,1])
C1522326 (UMLS CUI [3,2])
C0205411 (UMLS CUI [3,3])
Comorbidity Study Subject Participation Status Exclusion | Comorbidity Interferes with Compliance behavior
Item
any other concurrent condition which, in the opinion of the investigator, would preclude participation in or interfere with compliance
boolean
C0009488 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])
C2828389 (UMLS CUI [1,3])
C0009488 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C1321605 (UMLS CUI [2,3])
Substance Use Disorders
Item
alcohol or drug abuse
boolean
C0038586 (UMLS CUI [1])
Investigational New Drugs | Biological Factors | Investigational Medical Device
Item
undergoing or have undergone treatment with another investigational drug, biologic agent or device within 90 days of screening
boolean
C0013230 (UMLS CUI [1])
C0005515 (UMLS CUI [2])
C2346570 (UMLS CUI [3])
Serum creatinine abnormal | Gender
Item
abnormal serum creatinine concentration defined as > 1.5 mg/dl (132.6 micro mol/l) for males and > 1.2 mg/dl (106 micro mol/l) for females
boolean
C0438243 (UMLS CUI [1])
C0079399 (UMLS CUI [2])
Pharmaceutical Preparations Affecting Coagulation | Heparin | Warfarin | Aspirin | Anti-Inflammatory Agents, Non-Steroidal
Item
medications that may affect coagulation (heparin, warfarin, etc.) with the exception of acetylsalicylic acid or non-steroidal anti-inflammatory agents.
boolean
C0013227 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0005778 (UMLS CUI [1,3])
C0019134 (UMLS CUI [2])
C0043031 (UMLS CUI [3])
C0004057 (UMLS CUI [4])
C0003211 (UMLS CUI [5])
Sulfur allergy
Item
allergy to sulfur-containing medications
boolean
C0571095 (UMLS CUI [1])