Schizophrenia | Schizoaffective Disorder
Item
diagnosis of schizophrenia or schizoaffective disorder.
boolean
C0036341 (UMLS CUI [1])
C0036337 (UMLS CUI [2])
Brief Psychiatric Rating Scale | BPRS Psychotic symptom Cluster
Item
a minimum brief psychiatric rating scale (bprs) score of 35 and a bprs psychotic symptom cluster score of at least 8.
boolean
C0029941 (UMLS CUI [1])
C0029941 (UMLS CUI [2,1])
C0871189 (UMLS CUI [2,2])
C1704332 (UMLS CUI [2,3])
Clozapine Dose Stable | Clozapine In Blood Measurement
Item
currently taking clozapine with a blood level between 350-1000 ng/ml and on a stable dose of clozapine for the past 2 weeks.
boolean
C0009079 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
C0009079 (UMLS CUI [2,1])
C0005768 (UMLS CUI [2,2])
C0242485 (UMLS CUI [2,3])
Informed Consent
Item
able to give informed consent.
boolean
C0021430 (UMLS CUI [1])
Disease Significant | nervous system disorder Significant | Thyroid Disease | Renal abnormalities | Abnormality of the liver | Epilepsy
Item
a history of significant medical/neurological disease such as thyroid, renal, hepatic abnormality, seizure disorder.
boolean
C0012634 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
C0027765 (UMLS CUI [2,1])
C0750502 (UMLS CUI [2,2])
C0040128 (UMLS CUI [3])
C4014891 (UMLS CUI [4])
C4021780 (UMLS CUI [5])
C0014544 (UMLS CUI [6])
Neuroleptic Malignant Syndrome
Item
history of neuroleptic malignant syndrome.
boolean
C0027849 (UMLS CUI [1])
Substance Use Disorders Urine Toxicology
Item
current substance abuse determined by urine toxicology.
boolean
C0038586 (UMLS CUI [1,1])
C0042036 (UMLS CUI [1,2])
C0852616 (UMLS CUI [1,3])
Cardiac Arrhythmia | Sinus bradycardia | heart rate | Sinus Tachycardia | Supraventricular tachycardia | Tachycardia, Ventricular | Wolff-Parkinson-White Syndrome | First degree atrioventricular block | Second degree atrioventricular block | Complete atrioventricular block | Atrial Fibrillation | Atrial Flutter | Junctional premature complex | Electrocardiography
Item
cardiac arrhythmia, sinus bradycardia (heart rate less than 60/min), sinus tachycardia (heart rate greater than 110/min), supraventricular tachycardia, ventricular tachycardia, wolff-parkinson-white syndrome, first, second, third degree atrioventricular (av) block, atrial fibrillation, atrial flutter and junctional complexes. in baseline electrocardiogram (ekg). study doctors will examine the ekgs and consult with an internist/cardiologist as needed.
boolean
C0003811 (UMLS CUI [1])
C0085610 (UMLS CUI [2])
C0018810 (UMLS CUI [3])
C0039239 (UMLS CUI [4])
C0039240 (UMLS CUI [5])
C0042514 (UMLS CUI [6])
C0043202 (UMLS CUI [7])
C0085614 (UMLS CUI [8])
C0264906 (UMLS CUI [9])
C0151517 (UMLS CUI [10])
C0004238 (UMLS CUI [11])
C0004239 (UMLS CUI [12])
C0428981 (UMLS CUI [13])
C1623258 (UMLS CUI [14])
ECG QTc interval
Item
on ekg: qtc > 450 ms.
boolean
C2216079 (UMLS CUI [1])
Macrolide Antibiotics | Erythromycin | Clarithromycin | Azole antifungal | Ketoconazole | Itraconazole | Protease Inhibitors | Ritonavir | Indinavir | nefazodone | Pharmaceutical Preparations Associated with Prolonged QTc
Item
current use of macrolide antibiotics (e.g., erythromycin, clarithromycin), azole antifungal agents (e.g., ketoconazole, itraconazole), protease inhibitors (e.g., ritonavir, indinavir), nefazodone, and other medications that are associated with prolonged qtc.
boolean
C0003240 (UMLS CUI [1])
C0014806 (UMLS CUI [2])
C0055856 (UMLS CUI [3])
C0360363 (UMLS CUI [4])
C0022625 (UMLS CUI [5])
C0064113 (UMLS CUI [6])
C0033607 (UMLS CUI [7])
C0292818 (UMLS CUI [8])
C0376637 (UMLS CUI [9])
C0068485 (UMLS CUI [10])
C0013227 (UMLS CUI [11,1])
C0332281 (UMLS CUI [11,2])
C1969409 (UMLS CUI [11,3])
Antipsychotic Agents | Clozapine
Item
current use of antipsychotics other than clozapine.
boolean
C0040615 (UMLS CUI [1])
C0009079 (UMLS CUI [2])
Sertraline
Item
current use of sertraline.
boolean
C0074393 (UMLS CUI [1])
Intelligence quotient
Item
iq level below 70.
boolean
C0456149 (UMLS CUI [1])
Suicidal behavior High risk of | Homicidal behavior High risk of
Item
at high risk for suicidal/homicidal behavior.
boolean
C1760428 (UMLS CUI [1,1])
C0332167 (UMLS CUI [1,2])
C1828354 (UMLS CUI [2,1])
C0332167 (UMLS CUI [2,2])
Pregnancy | Childbearing Potential Contraceptive methods Lack | Gender Contraceptive methods | Contraceptives, Oral | Female Condoms | Contraception, Barrier | Sexual Abstinence | Female Sterilization
Item
pregnancy, lack of birth control for females of childbearing age (female patients must report use of effective method for birth control such as birth control pills, condoms, barrier methods, abstinence or have written statement from their doctors that they are medically sterile).
boolean
C0032961 (UMLS CUI [1])
C3831118 (UMLS CUI [2,1])
C0700589 (UMLS CUI [2,2])
C0332268 (UMLS CUI [2,3])
C0079399 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
C0009905 (UMLS CUI [4])
C0221829 (UMLS CUI [5])
C0004764 (UMLS CUI [6])
C0036899 (UMLS CUI [7])
C0015787 (UMLS CUI [8])
Able to speak English Language
Item
non-english speaking.
boolean
C0564215 (UMLS CUI [1,1])
C0376245 (UMLS CUI [1,2])