Age
Item
males and females, between ages 18 and 65 year sof age.
boolean
C0001779 (UMLS CUI [1])
Childbearing Potential Contraceptive methods
Item
females of childbearing potential must agree to use medically accepted means of contraception.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Schizophrenia
Item
a diagnosis of schizophrenia according to the dsm-iv.
boolean
C0036341 (UMLS CUI [1])
Therapeutic procedure Resistance
Item
subjects must meet retrospective criteria for treatment-resistance as defined:
boolean
C0087111 (UMLS CUI [1,1])
C1514892 (UMLS CUI [1,2])
Psychotic symptom Positive persistent
Item
1. persistent positive psychotic symptoms.
boolean
C0871189 (UMLS CUI [1,1])
C1514241 (UMLS CUI [1,2])
C0205322 (UMLS CUI [1,3])
Illness Moderate Brief Psychiatric Rating Scale
Item
2. current presence of at least a moderately severe illness as rated by the total bprs.
boolean
C0221423 (UMLS CUI [1,1])
C0205081 (UMLS CUI [1,2])
C0029941 (UMLS CUI [1,3])
Illness persistent
Item
3. persistence of illness- no evidence of good functioning in the last five years.
boolean
C0221423 (UMLS CUI [1,1])
C0205322 (UMLS CUI [1,2])
Condition Pharmaceutical Preparations refractory | Therapeutic procedure Quantity | Symptom relief Significant
Item
4. drug-refectory condition defined as at least two periods of treatment in the preceding significant symptom relief.
boolean
C0348080 (UMLS CUI [1,1])
C0013227 (UMLS CUI [1,2])
C0205269 (UMLS CUI [1,3])
C0087111 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C1457887 (UMLS CUI [3,1])
C0564405 (UMLS CUI [3,2])
C0750502 (UMLS CUI [3,3])
Informed Consent
Item
subjects must been judged competent to consent by the esc evaluation and provide voluntary informed consent.
boolean
C0021430 (UMLS CUI [1])
Protocol Compliance
Item
subjects must be reliable. they must agree to cooperate with all tests and examinations required by the protocol.
boolean
C0525058 (UMLS CUI [1])
Ophthalmoscopy Normal | complete examination of the eye | Abnormality of the lens
Item
patients msut have a normal ophthalmoscopic exam within 6 months of a full eye exam if any lense abnormality prior to entering study.
boolean
C0029090 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
C0848987 (UMLS CUI [2])
C0549651 (UMLS CUI [3])
Pregnancy | Breast Feeding
Item
females who are either pregnant or lactating.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Illness Serious Hospitalization Anticipated | Illness Serious Cessation of life Anticipated | Liver diseases | Kidney Diseases | gastroenterology Disease | Respiration Disorders | Cardiovascular Diseases | Endocrine System Diseases | nervous system disorder | Immune System Diseases | Hematological Disease
Item
serious medical illness including hepatic, renal, gastroenterologic, respiratory, cardiovascular, endocrinologic, neurologic, immunologic, or hematologic disease such that hospitalization for the disease is anticipated within three months or death is anticipated with three years.
boolean
C0221423 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0019993 (UMLS CUI [1,3])
C3840775 (UMLS CUI [1,4])
C0221423 (UMLS CUI [2,1])
C0205404 (UMLS CUI [2,2])
C0011065 (UMLS CUI [2,3])
C3840775 (UMLS CUI [2,4])
C0023895 (UMLS CUI [3])
C0022658 (UMLS CUI [4])
C0017163 (UMLS CUI [5,1])
C0012634 (UMLS CUI [5,2])
C0035204 (UMLS CUI [6])
C0007222 (UMLS CUI [7])
C0014130 (UMLS CUI [8])
C0027765 (UMLS CUI [9])
C0021053 (UMLS CUI [10])
C0018939 (UMLS CUI [11])
Drug Allergy Severe | Adverse reaction to drug multiple
Item
history of severe allergies or multiple adverse drug reactions.
boolean
C0013182 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0041755 (UMLS CUI [2,1])
C0439064 (UMLS CUI [2,2])
Substance Use Disorders | Substance Dependence
Item
dsm-iv substance abuse or dependence within the past month.
boolean
C0038586 (UMLS CUI [1])
C0038580 (UMLS CUI [2])
oeganic mental disorder
Item
any dsm-iv organic mental disorder.
boolean
C0029227 (UMLS CUI [1])
At risk for suicide Serious
Item
judged clinically to be at serious suicidal risk.
boolean
C0563664 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
Clozapine Poor response to treatment Clinical Global Impression Questionnaire
Item
definitive failure to show clinically significant response (improved in cgi score of at least 1 point) to and adequate trial of clozapine (600mg/day for at least 6 weeks)
boolean
C0009079 (UMLS CUI [1,1])
C1320680 (UMLS CUI [1,2])
C3639708 (UMLS CUI [1,3])
Seizures Uncontrolled
Item
uncontrolled seizures within the past 6 months.
boolean
C0036572 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])