Age
Item
male/females at least 20 years of age.
boolean
C0001779 (UMLS CUI [1])
Postmenopausal state | Female Sterilization | Gender Contraceptive methods
Item
females post-menopausal for at least 1 year, surgically sterile, or practicing acceptable methods of birth control.
boolean
C0232970 (UMLS CUI [1])
C0015787 (UMLS CUI [2])
C0079399 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
Gender Pregnancy test negative
Item
females have a negative pregnancy test at screening.
boolean
C0079399 (UMLS CUI [1,1])
C0427780 (UMLS CUI [1,2])
Rheumatoid Arthritis
Item
diagnosis of ra and met acr criteria.
boolean
C0003873 (UMLS CUI [1])
tumor necrosis factor therapy Discontinue
Item
must discontinue any tnf at least 2 months prior to baseline.
boolean
C0279936 (UMLS CUI [1,1])
C1444662 (UMLS CUI [1,2])
General health good
Item
in condition of general good health.
boolean
C1277245 (UMLS CUI [1])
Drug Allergy Significant | Substance Use Disorders Clinical Significance | Listeriosis | Tuberculosis | Lymphoma | leukemia | Anemia, Sickle Cell | Splenectomy | Malignant Neoplasms | Basal cell carcinoma Treated Successful | Squamous cell carcinoma of skin Treated Successful | Carcinoma in situ of uterine cervix Localized Treated Successful
Item
history of significant sensitivity to any drug; clinically significant drug or alcohol abuse within the past year; active infection with listeria or tb; lymphoma or leukemia; sickle-cell disease, splenectomy, other malignancy within 5 years with the exception of successfully treated non-metastatic basal cell or squamous cell carcinoma of skin or localized carcinoma in situ of the cervix.
boolean
C0013182 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
C0038586 (UMLS CUI [2,1])
C2826293 (UMLS CUI [2,2])
C0023860 (UMLS CUI [3])
C0041296 (UMLS CUI [4])
C0024299 (UMLS CUI [5])
C0023418 (UMLS CUI [6])
C0002895 (UMLS CUI [7])
C0037995 (UMLS CUI [8])
C0006826 (UMLS CUI [9])
C0007117 (UMLS CUI [10,1])
C1522326 (UMLS CUI [10,2])
C1272703 (UMLS CUI [10,3])
C0553723 (UMLS CUI [11,1])
C1522326 (UMLS CUI [11,2])
C1272703 (UMLS CUI [11,3])
C0851140 (UMLS CUI [12,1])
C0392752 (UMLS CUI [12,2])
C1522326 (UMLS CUI [12,3])
C1272703 (UMLS CUI [12,4])
inflammatory joint disease
Item
history of current acute inflammatory joint disease.
boolean
C0683381 (UMLS CUI [1])
Tamiflu | Symmetrel
Item
use of tamiflu or symmetrel within 3 months of study drug administration.
boolean
C0876173 (UMLS CUI [1])
C0026055 (UMLS CUI [2])
Influenza | Pneumococcal Infections
Item
recent (3 month) history of influenza or pneumococcal bacterial infection.
boolean
C0021400 (UMLS CUI [1])
C0032269 (UMLS CUI [2])
HIV Seropositivity
Item
known positive human immunodeficiency virus (hiv) status.
boolean
C0019699 (UMLS CUI [1])
Hepatitis B virus test positive | Hepatitis C virus test positive
Item
positive hepatitis b or hepatitis c virus.
boolean
C2748184 (UMLS CUI [1])
C2748185 (UMLS CUI [2])
Mantoux: positive
Item
positive ppd >5 mm.
boolean
C0032739 (UMLS CUI [1])
Plain chest X-ray Calcified granuloma | Plain chest X-ray Pleural scarring | Plain chest X-ray Abnormality Significant
Item
chest x-ray with calcified granulomas and/or pleural scarring or significant abnormalities.
boolean
C0039985 (UMLS CUI [1,1])
C0333404 (UMLS CUI [1,2])
C0039985 (UMLS CUI [2,1])
C0577703 (UMLS CUI [2,2])
C0039985 (UMLS CUI [3,1])
C1704258 (UMLS CUI [3,2])
C0750502 (UMLS CUI [3,3])