Rheumatoid Arthritis | Joint swelling Quantity | Joints tender Quantity
Item
meet acr criteria for diagnosis of active ra and have at >6 swollen joints and >9 tender joints
boolean
C0003873 (UMLS CUI [1])
C0152031 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0240094 (UMLS CUI [3,1])
C1265611 (UMLS CUI [3,2])
Disease-Modifying Antirheumatic Drugs Quantity | Effectiveness failed Quantity | Methotrexate
Item
subjects must have received at least one prior dmard besides mtx, but may have had efficacy failures on no more than four standard dmards other than mtx
boolean
C0242708 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C1280519 (UMLS CUI [2,1])
C0231175 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
C0025677 (UMLS CUI [3])
Methotrexate Duration | Methotrexate Dose Stable
Item
therapy with mtx for at least 6 months prior to screening and on a stable dose of mtx for at least 4 weeks prior to screening visit
boolean
C0025677 (UMLS CUI [1,1])
C0449238 (UMLS CUI [1,2])
C0025677 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0205360 (UMLS CUI [2,3])
Age
Item
age 18 years and older
boolean
C0001779 (UMLS CUI [1])
Tumor necrosis factor alpha (TNF-) inhibitors | adalimumab
Item
prior treatment with any tnf antagonist, including adalimumab
boolean
C3653350 (UMLS CUI [1])
C1122087 (UMLS CUI [2])
Substance Use Disorders Clinical Significance | Intravenous Drug Abuse | Listeriosis | Tuberculosis | Lymphoma | leukemia | Malignant Neoplasms | Basal cell carcinoma Treated Successful
Item
history of clinically significant drug or alcohol abuse in the previous year, iv drug abuse, active infection with listeria or tuberculosis (tb), lymphoma or leukemia,and any malignancy with the exception of successfully treated non-metastatic basal-cell carcinoma of the skin.
boolean
C0038586 (UMLS CUI [1,1])
C2826293 (UMLS CUI [1,2])
C0086181 (UMLS CUI [2])
C0023860 (UMLS CUI [3])
C0041296 (UMLS CUI [4])
C0024299 (UMLS CUI [5])
C0023418 (UMLS CUI [6])
C0006826 (UMLS CUI [7])
C0007117 (UMLS CUI [8,1])
C1522326 (UMLS CUI [8,2])
C1272703 (UMLS CUI [8,3])
Vaccines, Attenuated | Investigational New Drugs | Biological Factors Investigational | Anti-CD4 Monoclonal Antibody | Tumor necrosis factor alpha (TNF-) inhibitors | adalimumab | Exposure to Alkylating Agents | Exposure to Chlorambucil | Exposure to Cyclophosphamide
Item
subjects may not have been administered a live vaccine within three months prior to study drug administration or during the study, treatment with any other investigational agent within 30 days or 5 half-lives of the agent, whichever is longer, prior to the screening evaluation, treatment with any investigational biologic agent, including anti-cd4 antibody, within 6 months prior to the screening evaluation, prior treatment with any tnf antagonist, including adalimumab, prior exposure to alkylating agents such as chlorambucil or cyclophosphamide.
boolean
C0042211 (UMLS CUI [1])
C0013230 (UMLS CUI [2])
C0005515 (UMLS CUI [3,1])
C1517586 (UMLS CUI [3,2])
C3831519 (UMLS CUI [4])
C3653350 (UMLS CUI [5])
C1122087 (UMLS CUI [6])
C0332157 (UMLS CUI [7,1])
C0002073 (UMLS CUI [7,2])
C0332157 (UMLS CUI [8,1])
C0008163 (UMLS CUI [8,2])
C0332157 (UMLS CUI [9,1])
C0010583 (UMLS CUI [9,2])
Calcified granuloma Plain chest X-ray | Pleural scarring Plain chest X-ray
Item
chest x-ray with calcified granuloma and/or pleural scarring
boolean
C0333404 (UMLS CUI [1,1])
C0039985 (UMLS CUI [1,2])
C0577703 (UMLS CUI [2,1])
C0039985 (UMLS CUI [2,2])
TB skin test result Positive | Tuberculin Test Purified protein derivative - RT23
Item
positive tb skin test, rt23 dose skin test, >5 mm at 48 to 72 hours
boolean
C0848706 (UMLS CUI [1,1])
C1514241 (UMLS CUI [1,2])
C0041290 (UMLS CUI [2,1])
C0444605 (UMLS CUI [2,2])
Myocardial Ischemia Unstable | Inflammatory Bowel Diseases | Peptic Ulcer | Cerebrovascular accident Recent | Medical condition Poorly controlled
Item
unstable ischemic heart disease, active inflammatory bowel disease, active peptic ulcer disease, recent stroke (within 3 months of the screening evaluation) or any poorly controlled medical condition
boolean
C0151744 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
C0021390 (UMLS CUI [2])
C0030920 (UMLS CUI [3])
C0038454 (UMLS CUI [4,1])
C0332185 (UMLS CUI [4,2])
C3843040 (UMLS CUI [5,1])
C3853134 (UMLS CUI [5,2])
intraarticular injection of corticosteroids | Adrenal Cortex Hormones Intramuscular | Adrenal Cortex Hormones Intravenous
Item
intra-articular, intramuscular or iv administration of corticosteroids within 4 weeks prior to screening evaluation
boolean
C2064783 (UMLS CUI [1])
C0001617 (UMLS CUI [2,1])
C1556154 (UMLS CUI [2,2])
C0001617 (UMLS CUI [3,1])
C1522726 (UMLS CUI [3,2])
Pregnancy | Breast Feeding
Item
female who is pregnant or breast-feeding.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])