Multiple Myeloma | Plasmacytoma | Biopsy | BONE MARROW PLASMACYTOSIS | Monoclonal immunoglobulin present | serum electrophoresis test | Lytic lesion
Item
diagnosis of multiple myeloma based on standard diagnosis criteria: plasmacytomas on tissue biopsy; bone marrow plasmacytosis; monoclonal immunoglobulin spike on serum electrophoresis; lytic bone lesions.
boolean
C0026764 (UMLS CUI [1])
C0032131 (UMLS CUI [2])
C0005558 (UMLS CUI [3])
C0238803 (UMLS CUI [4])
C0860896 (UMLS CUI [5])
C0851095 (UMLS CUI [6])
C0221204 (UMLS CUI [7])
Recurrent disease | Recurrent disease refractory
Item
must have relapsed or relapsed/refractory disease
boolean
C0277556 (UMLS CUI [1])
C0277556 (UMLS CUI [2,1])
C0205269 (UMLS CUI [2,2])
Age
Item
18 years of age or older
boolean
C0001779 (UMLS CUI [1])
Baseline Tests Duration
Item
all baseline studies must be performed within 21 days of enrollment.
boolean
C1442488 (UMLS CUI [1,1])
C0392366 (UMLS CUI [1,2])
C0449238 (UMLS CUI [1,3])
ECOG performance status
Item
ecog performance status of 0 to 2
boolean
C1520224 (UMLS CUI [1])
Renal Insufficiency | Creatinine measurement, serum
Item
renal insufficiency (serum creatinine levels > 2mg/dl)
boolean
C1565489 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
Pharmacotherapy Including Adrenal Cortex Hormones
Item
concomitant therapy medications that include corticosteroids
boolean
C0013216 (UMLS CUI [1,1])
C0332257 (UMLS CUI [1,2])
C0001617 (UMLS CUI [1,3])
Peripheral Neuropathy CTCAE Grades | Pain CTCAE Grades
Item
peripheral neuropathy of grade 3 or greater or painful grade 2
boolean
C0031117 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
C0030193 (UMLS CUI [2,1])
C1516728 (UMLS CUI [2,2])
Mucosal bleeding Evidence of | Internal hemorrhage Evidence of | Platelet Transfusion refractory
Item
evidence of mucosal or internal bleeding and/or platelet refractory
boolean
C2748540 (UMLS CUI [1,1])
C0332120 (UMLS CUI [1,2])
C1390214 (UMLS CUI [2,1])
C0332120 (UMLS CUI [2,2])
C0086818 (UMLS CUI [3,1])
C0205269 (UMLS CUI [3,2])
Absolute neutrophil count
Item
anc < 1000 cells/mm3
boolean
C0948762 (UMLS CUI [1])
Hemoglobin measurement
Item
hemoglobin < 8.0 g/dl
boolean
C0518015 (UMLS CUI [1])
Aspartate aminotransferase measurement | Alanine aminotransferase measurement
Item
ast (sgot and alt) > 2 x uln
boolean
C0201899 (UMLS CUI [1])
C0201836 (UMLS CUI [2])
intolerance to bortezomib | intolerance to CC-5013 | Hypersensitivity Significant Boron Compound | Hypersensitivity Significant Mannitol Compound
Item
intolerance to bortezomib or cc-5013 in the past or significant allergy to either compound, boron or mannitol
boolean
C1744706 (UMLS CUI [1,1])
C1176309 (UMLS CUI [1,2])
C1744706 (UMLS CUI [2,1])
C1134588 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3,1])
C0750502 (UMLS CUI [3,2])
C0006031 (UMLS CUI [3,3])
C0020517 (UMLS CUI [4,1])
C0750502 (UMLS CUI [4,2])
C0024730 (UMLS CUI [4,3])
C1706082 (UMLS CUI [4,4])
Hypersensitivity Thalidomide | Erythema Nodosum
Item
known hypersensitivity to thalidomide or the development of erythema nodosum
boolean
C0020517 (UMLS CUI [1,1])
C0039736 (UMLS CUI [1,2])
C0014743 (UMLS CUI [2])
Communicable Disease | Comorbidity Serious
Item
active infection or serious co-morbid medical condition
boolean
C0009450 (UMLS CUI [1])
C0009488 (UMLS CUI [2,1])
C0205404 (UMLS CUI [2,2])
Pregnancy | Breast Feeding
Item
pregnant or breast-feeding women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Malignant Neoplasms | Basal cell carcinoma Treated | Squamous cell carcinoma of skin Treated | Carcinoma in situ of uterine cervix Treated | Carcinoma in situ of female breast Treated | Carcinoma in situ of prostate Treated
Item
prior malignancy with the last three years except adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, in situ breast cancer, on in-situ prostate cancer
boolean
C0006826 (UMLS CUI [1])
C0007117 (UMLS CUI [2,1])
C1522326 (UMLS CUI [2,2])
C0553723 (UMLS CUI [3,1])
C1522326 (UMLS CUI [3,2])
C0851140 (UMLS CUI [4,1])
C1522326 (UMLS CUI [4,2])
C0686288 (UMLS CUI [5,1])
C1522326 (UMLS CUI [5,2])
C0154088 (UMLS CUI [6,1])
C1522326 (UMLS CUI [6,2])