criteria Fulfill
Item
subjects for this study will meet the following criteria:
boolean
C0243161 (UMLS CUI [1,1])
C1550543 (UMLS CUI [1,2])
Postpartum mood disturbance Moderate Disease length | Depressive disorder Onset Period Normal vaginal delivery | Depressive disorder Onset Period Cesarean section Uncomplicated
Item
1. a history of at least two weeks with postpartum-related mood disturbances of moderate severity, and self-report of the onset of depression within three months of a normal vaginal delivery or uncomplicated caesarean section;
boolean
C2909480 (UMLS CUI [1,1])
C0205081 (UMLS CUI [1,2])
C0872146 (UMLS CUI [1,3])
C0011581 (UMLS CUI [2,1])
C0332162 (UMLS CUI [2,2])
C1948053 (UMLS CUI [2,3])
C0269694 (UMLS CUI [2,4])
C0011581 (UMLS CUI [3,1])
C0332162 (UMLS CUI [3,2])
C1948053 (UMLS CUI [3,3])
C0007876 (UMLS CUI [3,4])
C0443334 (UMLS CUI [3,5])
Minor depressive disorder Episode of | Moderate major depression, single episode | Mild major depression, single episode | Feeling suicidal | Beck depression inventory | Center for Epidemiologic Studies Depression Scale | Hamilton rating scale for depression | Severe major depression | Severe postnatal psychosis | Immediate treatment claim Post Assessment Clinical
Item
2. a current episode of minor (meeting 3-4 criterion symptoms) or major depression (of moderate severity or less on the scid severity scale and not meeting dsm-iv criteria symptom 9 [suicidal ideation]) as determined by the administration of the minor depression module of the sads-l and the structured clinical interview for dsm-iv. additionally, to ensure that subjects meet a minimum threshold for severity of depression, subjects will have scores greater than or equal to 10 on either the beck depression inventory (bdi) or the center for epidemiologic studies - depression (ces-d) scale during at least three of the six clinic visits during the two week screening phase, as well as a 17 item hamilton depression score greater than or equal to 10. subjects will be excluded if they meet any of the following criteria: major depression of greater than moderate severity (including postpartum psychosis). dsm-iv criteria #9 (suicidal ideation), or anyone requiring immediate treatment after clinical assessment.
boolean
C0520675 (UMLS CUI [1,1])
C0332189 (UMLS CUI [1,2])
C0154404 (UMLS CUI [2])
C0154403 (UMLS CUI [3])
C0424000 (UMLS CUI [4])
C0451022 (UMLS CUI [5])
C2699160 (UMLS CUI [6])
C0451203 (UMLS CUI [7])
C3472470 (UMLS CUI [8])
C0342073 (UMLS CUI [9])
C0583047 (UMLS CUI [10,1])
C0687676 (UMLS CUI [10,2])
C1516048 (UMLS CUI [10,3])
C0205210 (UMLS CUI [10,4])
Period Post Delivery
Item
3. not greater than six months post delivery;
boolean
C1948053 (UMLS CUI [1,1])
C0687676 (UMLS CUI [1,2])
C0011209 (UMLS CUI [1,3])
Age
Item
4. age 20 to 45;
boolean
C0001779 (UMLS CUI [1])
General health good | Pharmaceutical Preparations Regular | Dietary Supplements Regular | Herbal supplement Regular | Multivitamin preparation | CALCIUM SUPPLEMENTS
Item
5.) in good medical health, and not taking any medication or dietary and herbal supplements on a regular basis (with the exception of multivitamins or calcium supplements).
boolean
C1277245 (UMLS CUI [1])
C0013227 (UMLS CUI [2,1])
C0205272 (UMLS CUI [2,2])
C0242295 (UMLS CUI [3,1])
C0205272 (UMLS CUI [3,2])
C1504473 (UMLS CUI [4,1])
C0205272 (UMLS CUI [4,2])
C0301532 (UMLS CUI [5])
C3540037 (UMLS CUI [6])
Condition Causing Medical contraindication Therapeutic procedure | Study Subject Participation Status Exclusion
Item
the following conditions will constitute contraindications to treatment and will preclude a subject s participation in this protocol:
boolean
C0348080 (UMLS CUI [1,1])
C0678227 (UMLS CUI [1,2])
C1301624 (UMLS CUI [1,3])
C0087111 (UMLS CUI [1,4])
C2348568 (UMLS CUI [2,1])
C2828389 (UMLS CUI [2,2])
Severe major depression
Item
1) severe major depression with any of the following:
boolean
C3472470 (UMLS CUI [1])
Feeling suicidal Response Threshold Positive
Item
1. positive (threshold) response to scid major depression section item # 9, suicidal ideation;
boolean
C0424000 (UMLS CUI [1,1])
C1704632 (UMLS CUI [1,2])
C0449864 (UMLS CUI [1,3])
C1514241 (UMLS CUI [1,4])
Immediate treatment claim Post Assessment Clinical
Item
2. anyone requiring immediate treatment after clinical assessment;
boolean
C0583047 (UMLS CUI [1,1])
C0687676 (UMLS CUI [1,2])
C1516048 (UMLS CUI [1,3])
C0205210 (UMLS CUI [1,4])
Severity rating | Severe postnatal psychosis
Item
3. severity ratings greater than moderate on the scid iv interview (including postpartum psychosis);
boolean
C1830455 (UMLS CUI [1])
C0342073 (UMLS CUI [2])
Antidepressive Agents
Item
2) current treatment with antidepressant medications
boolean
C0003289 (UMLS CUI [1])
Mental disorder Before Onset of Depressive episode | Mania | Postpartum psychosis
Item
3) history of psychiatric illness during the two years before the reported onset of the current episode of depression or a history of either mania (dsm-iv criteria) or postpartum psychosis at any time in the past.
boolean
C0004936 (UMLS CUI [1,1])
C0332152 (UMLS CUI [1,2])
C0332162 (UMLS CUI [1,3])
C0349217 (UMLS CUI [1,4])
C0338831 (UMLS CUI [2])
C0520678 (UMLS CUI [3])
Myocardial Ischemia | Pulmonary Embolism | Retinal thrombosis | Thrombophlebitis | Thromboembolism risk factors | Cigarette smoker Number of cigarettes per day | Varicosity | Immobilisation prolonged | travel Prolonged | Heart Disease
Item
4) history of ischemic cardiac disease, pulmonary embolism, retinal thrombosis, or thrombophlebitis; any subject with risk factors for thrombo-embolic phenomena including cigarette smokers (greater than 10 cigarettes per day), varicose veins, patients with prolonged periods of immobilization (including prolonged travel), and active heart disease.
boolean
C0151744 (UMLS CUI [1])
C0034065 (UMLS CUI [2])
C1579873 (UMLS CUI [3])
C0040046 (UMLS CUI [4])
C0040038 (UMLS CUI [5,1])
C0035648 (UMLS CUI [5,2])
C0337667 (UMLS CUI [6,1])
C3694146 (UMLS CUI [6,2])
C0042345 (UMLS CUI [7])
C0919574 (UMLS CUI [8])
C0040802 (UMLS CUI [9,1])
C0439590 (UMLS CUI [9,2])
C0018799 (UMLS CUI [10])
Kidney Disease | Asthma
Item
5) renal disease, asthma
boolean
C0022658 (UMLS CUI [1])
C0004096 (UMLS CUI [2])
Liver Dysfunction
Item
6) hepatic dysfunction
boolean
C0086565 (UMLS CUI [1])
Breast Carcinoma | Premenopausal breast cancer First Degree Relative | bilateral breast cancer First Degree Relative | Breast Carcinoma Postmenopausal Family members Quantity
Item
7) women with a history of carcinoma of the breast, or women with a family history of the following: premenopausal breast cancer or bilateral breast cancer in a first degree relative; multiple family members (greater than three relatives) with postmenopausal breast cancer
boolean
C0678222 (UMLS CUI [1])
C0741682 (UMLS CUI [2,1])
C1517194 (UMLS CUI [2,2])
C0281267 (UMLS CUI [3,1])
C1517194 (UMLS CUI [3,2])
C0678222 (UMLS CUI [4,1])
C0232970 (UMLS CUI [4,2])
C0086282 (UMLS CUI [4,3])
C1265611 (UMLS CUI [4,4])
Uterine Cancer | Endometriosis | Lesion Pelvic | Ovarian enlargement Undiagnosed | Vaginal Hemorrhage Undiagnosed
Item
8) women with a history of uterine cancer, endometriosis, ill-defined pelvic lesions, particularly undiagnosed ovarian enlargement, undiagnosed vaginal bleeding
boolean
C0153567 (UMLS CUI [1])
C0014175 (UMLS CUI [2])
C0221198 (UMLS CUI [3,1])
C0030797 (UMLS CUI [3,2])
C0392039 (UMLS CUI [4,1])
C1408353 (UMLS CUI [4,2])
C2979982 (UMLS CUI [5,1])
C1408353 (UMLS CUI [5,2])
Estradiol allergy | Hypersensitivity Transdermal Patch | Hypersensitivity medroxyprogesterone acetate
Item
9) patients with a known hypersensitivity of estradiol, transdermal skin patches, or medroxyprogesterone acetate
boolean
C0571688 (UMLS CUI [1])
C0020517 (UMLS CUI [2,1])
C0991556 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3,1])
C0065864 (UMLS CUI [3,2])
Pregnancy
Item
10) pregnant women
boolean
C0032961 (UMLS CUI [1])
Porphyria
Item
11) porphyria
boolean
C3463940 (UMLS CUI [1])
Diabetes Mellitus
Item
12) diabetes mellitus
boolean
C0011849 (UMLS CUI [1])
Cholecystitis | Pancreatitis
Item
13) cholecystitis or pancreatitis
boolean
C0008325 (UMLS CUI [1])
C0030305 (UMLS CUI [2])
Cerebrovascular Disorders | Cerebrovascular accident | Epilepsy | Hypertensive disease | Hypercalcemia
Item
14) history of cerebrovascular disease (stroke), epilepsy, hypertension, hypercalcemia
boolean
C0007820 (UMLS CUI [1])
C0038454 (UMLS CUI [2])
C0014544 (UMLS CUI [3])
C0020538 (UMLS CUI [4])
C0020437 (UMLS CUI [5])
Migraine Disorders Recurrent
Item
15) recurrent migraine headaches
boolean
C0149931 (UMLS CUI [1,1])
C2945760 (UMLS CUI [1,2])
melanoma
Item
16) malignant melanoma
boolean
C0025202 (UMLS CUI [1])
Familial hyperlipoproteinemia
Item
17) history of familial hyperlipoproteinemia
boolean
C0700623 (UMLS CUI [1])
Prior Hormone Therapy Postpartum mood disturbance | physical symptom
Item
18) prior hormonal therapy for the treatment of postpartum-related mood or physical symptoms within the last six months
boolean
C1514460 (UMLS CUI [1,1])
C2909480 (UMLS CUI [1,2])
C0679309 (UMLS CUI [2])
Mental disorder Before Onset of Depressive episode
Item
19) history of psychiatric illness during the two years prior to the reported onset of the current episode of depression
boolean
C0004936 (UMLS CUI [1,1])
C0332152 (UMLS CUI [1,2])
C0332162 (UMLS CUI [1,3])
C0349217 (UMLS CUI [1,4])