Parkinson Disease disabling Unresponsive to Treatment | Motor fluctuations | Dyskinetic syndrome | Freezing of gait Episode of
Item
intractable, disabling pd with motor fluctuations, dyskinesias, or freezing episodes
boolean
C0030567 (UMLS CUI [1,1])
C0596452 (UMLS CUI [1,2])
C0205269 (UMLS CUI [1,3])
C1868976 (UMLS CUI [2])
C0013384 (UMLS CUI [3])
C0860515 (UMLS CUI [4,1])
C0332189 (UMLS CUI [4,2])
Age
Item
age between 30-75 years
boolean
C0001779 (UMLS CUI [1])
Antiparkinson Agents High dose | Antiparkinson Agents Low dose | Unresponsive to Treatment
Item
unsatisfactory clinical response to maximal medical management (with trials of both higher and lower doses of anti-parkinsonian drugs)
boolean
C0003405 (UMLS CUI [1,1])
C0444956 (UMLS CUI [1,2])
C0003405 (UMLS CUI [2,1])
C0445550 (UMLS CUI [2,2])
C0205269 (UMLS CUI [3])
Antiparkinson Agents Optimal Stable Before Operative Surgical Procedure
Item
a stable and optimal medical regimen of anti-parkinsonian drug therapy for at least three months prior to surgery
boolean
C0003405 (UMLS CUI [1,1])
C2698651 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
C0332152 (UMLS CUI [1,4])
C0543467 (UMLS CUI [1,5])
Handedness | assessment of mood | Assessment: Cognition
Item
patients must be right-handed to be included in the study since mood and cognition are being analyzed and right hemisphere dominant patients could confound the results.
boolean
C0023114 (UMLS CUI [1])
C2237119 (UMLS CUI [2])
C0870300 (UMLS CUI [3])
Disease Clinical Significance At risk Complication Preoperative | Disease Clinical Significance At risk Postoperative Complications | Heart Disease Significant | Lung disease Significant | Uncontrolled hypertension
Item
clinically significant medical disease that would increase risk of developing pre- or postoperative complications (e.g., significant cardiac or pulmonary disease, uncontrolled hypertension)
boolean
C0012634 (UMLS CUI [1,1])
C2826293 (UMLS CUI [1,2])
C1444641 (UMLS CUI [1,3])
C0009566 (UMLS CUI [1,4])
C0445204 (UMLS CUI [1,5])
C0012634 (UMLS CUI [2,1])
C2826293 (UMLS CUI [2,2])
C1444641 (UMLS CUI [2,3])
C0032787 (UMLS CUI [2,4])
C0018799 (UMLS CUI [3,1])
C0750502 (UMLS CUI [3,2])
C0024115 (UMLS CUI [4,1])
C0750502 (UMLS CUI [4,2])
C1868885 (UMLS CUI [5])
Secondary Parkinson Disease | Parkinsonian Disorders Atypical | Cerebrovascular accident Quantity | Exposure to toxin | Antipsychotic Agents Exposure to | Encephalitis | Upper Motor Neuron Disease Neurologic Signs | Involvement Cerebellar | Supranuclear gaze palsy | Hypotension orthostatic Significant
Item
evidence of secondary or atypical parkinsonism as suggested by the presence of any of the following: 1) history of stroke(s), 2) exposure to toxins or neuroleptics, 3) history of encephalitis, 4) neurological signs of upper motor neuron disease, cerebellar involvement, supranuclear gaze palsy, or significant orthostatic hypotension
boolean
C0030569 (UMLS CUI [1])
C0242422 (UMLS CUI [2,1])
C0205182 (UMLS CUI [2,2])
C0038454 (UMLS CUI [3,1])
C1265611 (UMLS CUI [3,2])
C0040537 (UMLS CUI [4])
C0040615 (UMLS CUI [5,1])
C0332157 (UMLS CUI [5,2])
C0014038 (UMLS CUI [6])
C0521659 (UMLS CUI [7,1])
C0751378 (UMLS CUI [7,2])
C1314939 (UMLS CUI [8,1])
C0007765 (UMLS CUI [8,2])
C1720037 (UMLS CUI [9])
C0020651 (UMLS CUI [10,1])
C0750502 (UMLS CUI [10,2])
MRI Scans | Cerebral atrophy Evidence Significant | Abnormality Evidence Significant | Infarction, Lacunar | Iron Deposits putamen
Item
mri scan with significant evidence of brain atrophy or other abnormalities (e.g., lacunar infarcts or iron deposits in the putamen)
boolean
C0917711 (UMLS CUI [1])
C0235946 (UMLS CUI [2,1])
C3887511 (UMLS CUI [2,2])
C0750502 (UMLS CUI [2,3])
C1704258 (UMLS CUI [3,1])
C3887511 (UMLS CUI [3,2])
C0750502 (UMLS CUI [3,3])
C0333559 (UMLS CUI [4])
C0302583 (UMLS CUI [5,1])
C0333562 (UMLS CUI [5,2])
C1281335 (UMLS CUI [5,3])
Clinical dementia rating scale | Dementia Clinical
Item
the mattis dementia rating scale will be used to assess the level of intellectual function and patients will be excluded with scores reflecting clinical dementia
boolean
C0451074 (UMLS CUI [1])
C0497327 (UMLS CUI [2,1])
C0205210 (UMLS CUI [2,2])
Mental disorder Major
Item
a major psychiatric disorder on the structured clinical interview for dsm-iv (scid-iv).
boolean
C0004936 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])