Parkinson Disease
Item
patients with pd corresponding to inclusion criteria will be recruited from the human motor control section clinic (hmcs).
boolean
C0030567 (UMLS CUI [1])
Age | Parkinson Disease Dopa Responsive | Parkinson Disease Akinetic Rigid
Item
subjects will be men and women aged 40-80 years with dopa-responsive, akinetic-rigid pd.
boolean
C0001779 (UMLS CUI [1])
C0030567 (UMLS CUI [2,1])
C0013023 (UMLS CUI [2,2])
C0205342 (UMLS CUI [2,3])
C0030567 (UMLS CUI [3,1])
C0233568 (UMLS CUI [3,2])
C0026837 (UMLS CUI [3,3])
Study Subject Participation Status | patient interview | Physical Examination | Parkinson Disease | Condition Neurologic | Hoehn and Yahr grades
Item
patients who have never participated in hmcs protocols for pd will be interviewed and examined by either the principal investigator or a physician from the brain stimulation unit or hmcs in order to establish the diagnosis of pd and rule out any neurological condition. only patients with a hoehm and yahr grade of 2 to 4 while "off" will be accepted.
boolean
C2348568 (UMLS CUI [1])
C0683518 (UMLS CUI [2])
C0031809 (UMLS CUI [3])
C0030567 (UMLS CUI [4])
C0348080 (UMLS CUI [5,1])
C0205494 (UMLS CUI [5,2])
C0451215 (UMLS CUI [6])
Levodopa | Dopamine Agonists | Medication dose per day Dopamine Equivalent | Antiparkinson Agents
Item
patients must be on a regimen including levodopa. the total dose of levodopa and dopamine agonists (using dopamine equivalents) has to be equal to or more than 375 milligrams per day. other anti-parkinsonian medications are also acceptable.
boolean
C0023570 (UMLS CUI [1])
C0178601 (UMLS CUI [2])
C3174092 (UMLS CUI [3,1])
C0439505 (UMLS CUI [3,2])
C0013030 (UMLS CUI [3,3])
C0205163 (UMLS CUI [3,4])
C0003405 (UMLS CUI [4])
Difficulty walking | Freezing | Gait Time Distance
Item
patients should have problems with walking, including freezing, so that their gait time for a 10-meter distance will be six seconds or more.
boolean
C0311394 (UMLS CUI [1])
C0860515 (UMLS CUI [2])
C0016928 (UMLS CUI [3,1])
C0040223 (UMLS CUI [3,2])
C0012751 (UMLS CUI [3,3])
Illness Significant | Mental disorders Significant | Parkinson Disease | Levodopa | Sundowning | Hallucinations Benign | Pallidotomy | Electrodes, Implanted | Deep brain electrical stimulation system pulse generator | Pregnancy
Item
exclusion criteria are any significant medical or psychiatric illnesses (except those symptoms often associated with pd or levodopa therapy, such as sundowning and benign hallucination), pallidotomy, implanted electrodes and generator for deep brain stimulation, pregnancy.
boolean
C0221423 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
C0004936 (UMLS CUI [2,1])
C0750502 (UMLS CUI [2,2])
C0030567 (UMLS CUI [3])
C0023570 (UMLS CUI [4])
C1142436 (UMLS CUI [5])
C0018524 (UMLS CUI [6,1])
C0205183 (UMLS CUI [6,2])
C0195893 (UMLS CUI [7])
C0013814 (UMLS CUI [8])
C4075668 (UMLS CUI [9])
C0032961 (UMLS CUI [10])
Implanted Medical Device | Artificial cardiac pacemaker | pump Medical Implant | Hearing Aids Implant | skull-plate; present | Metallic foreign body skull | Metal foreign body in eye region | Dental appliances | tooth filling | Physical hazard | Total Hip Replacement | Illness Significant
Item
persons with surgically or traumatically implanted foreign bodies such as a pacemaker, implanted medical pump, implanted hearing aids, metal plate in the skull, or metal implant in the skull or eyes (other than dental appliances or fillings) that may pose a physical hazard during tep will also be excluded. most of these exclusions also come under the category of significant medical illness.
boolean
C2828363 (UMLS CUI [1])
C0030163 (UMLS CUI [2])
C0182537 (UMLS CUI [3,1])
C0205476 (UMLS CUI [3,2])
C0021102 (UMLS CUI [3,3])
C0018768 (UMLS CUI [4,1])
C0021102 (UMLS CUI [4,2])
C1409480 (UMLS CUI [5])
C1720389 (UMLS CUI [6,1])
C2951888 (UMLS CUI [6,2])
C0562528 (UMLS CUI [7])
C0441319 (UMLS CUI [8])
C0178866 (UMLS CUI [9])
C0337044 (UMLS CUI [10])
C0040508 (UMLS CUI [11])
C0221423 (UMLS CUI [12,1])
C0750502 (UMLS CUI [12,2])
Reasons At risk Study Subject Participation Status | Tendency to fall | Fatigue Excessive | Frailty General | apprehensiveness Excessive
Item
patients for whom participation in the study would, in the opinion of the investigators, cause undue risk or stress for reasons such as tendency to fall, excessive fatigue, general frailty, or excessive apprehensiveness will also be excluded.
boolean
C3841427 (UMLS CUI [1,1])
C1444641 (UMLS CUI [1,2])
C2348568 (UMLS CUI [1,3])
C2830327 (UMLS CUI [2])
C0015672 (UMLS CUI [3,1])
C0442802 (UMLS CUI [3,2])
C0424594 (UMLS CUI [4,1])
C0205246 (UMLS CUI [4,2])
C1408583 (UMLS CUI [5,1])
C0442802 (UMLS CUI [5,2])
Able to walk Distance
Item
patients unable to walk a 10-meter distance will be excluded.
boolean
C2712089 (UMLS CUI [1,1])
C0012751 (UMLS CUI [1,2])
Mentally Disabled Persons | Informed Consent Unable
Item
mentally impaired patients having no capacity to provide their own consent will be excluded from the study.
boolean
C0079822 (UMLS CUI [1])
C0021430 (UMLS CUI [2,1])
C1299582 (UMLS CUI [2,2])