Age | Parkinson Disease Dopa Responsive | Parkinson Disease Akinetic Rigid
Item
subjects will be men and women aged 40 to 80 years with dopa-responsive, akinetic-rigid pd.
boolean
C0001779 (UMLS CUI [1])
C0030567 (UMLS CUI [2,1])
C0013023 (UMLS CUI [2,2])
C0205342 (UMLS CUI [2,3])
C0030567 (UMLS CUI [3,1])
C0233568 (UMLS CUI [3,2])
C0026837 (UMLS CUI [3,3])
Informed Consent | patient interview | Physical Examination | Parkinson Disease | Condition Neurologic
Item
after obtaining the informed consent, patients will be interviewed and examined by either the prinicipal investigator (pi) or a brain stimulation unit (bsu) or an hmcs physician to establish the diagnosis of pd and rule out any other neurologic condition.
boolean
C0021430 (UMLS CUI [1])
C0683518 (UMLS CUI [2])
C0031809 (UMLS CUI [3])
C0030567 (UMLS CUI [4])
C0348080 (UMLS CUI [5,1])
C0205494 (UMLS CUI [5,2])
Hoehn and Yahr grades
Item
only patients with a hoehn and yahr grade of 2 to 4 while 'off' will be accepted.
boolean
C0451215 (UMLS CUI [1])
Levodopa | Medication dose Levodopa Equivalent | Dopamine Agonists
Item
patients must be on a regimen including l-dopa, and they must have a total dose of medication equal to more than 300 mg of l-dopa equivalent, including their dopamine agonist agents.
boolean
C0023570 (UMLS CUI [1])
C3174092 (UMLS CUI [2,1])
C0023570 (UMLS CUI [2,2])
C0205163 (UMLS CUI [2,3])
C0178601 (UMLS CUI [3])
Neurologic Examination
Item
any patient whose record does not contain a neurological examination from the past year will be reexamined before enrollment.
boolean
C0027853 (UMLS CUI [1])
Illness | Mental disorders | Parkinson Disease | Pregnancy | Epilepsy | Tricyclic Antidepressive Agents | Antipsychotic Agents | Pharmaceutical Preparations Lowered convulsive threshold | Illicit Drugs Lowered convulsive threshold | Antiparkinson Agents
Item
any significant medical or psychiatric illness (other than pd), pregnancy, history of epilepsy, or concurrent use of tricyclic antidepressants, neuroleptic agents, or any other licit or illicit drugs other than antiparkinsonian agents that could lower the seizure threshold.
boolean
C0221423 (UMLS CUI [1])
C0004936 (UMLS CUI [2])
C0030567 (UMLS CUI [3])
C0032961 (UMLS CUI [4])
C0014544 (UMLS CUI [5])
C0003290 (UMLS CUI [6])
C0040615 (UMLS CUI [7])
C0013227 (UMLS CUI [8,1])
C0234976 (UMLS CUI [8,2])
C0086190 (UMLS CUI [9,1])
C0234976 (UMLS CUI [9,2])
C0003405 (UMLS CUI [10])
Implanted Medical Device | Artificial cardiac pacemaker | Stimulator Implant | Pharmaceutical Preparations pump Implant | skull-plate; present | Metal foreign body in eye region | Dental appliances | tooth filling | Physical hazard | Magnetic Field Therapy
Item
persons with surgically or traumatically implanted foreign bodies such as a pacemaker, or any implanted stimulators, an implanted medication pump, a metal plate in the skull, or metal inside the skull or eyes (other than dental appliances or fillings) that may pose a physical hazard during magnetic stimulation will also be excluded.
boolean
C2828363 (UMLS CUI [1])
C0030163 (UMLS CUI [2])
C0175727 (UMLS CUI [3,1])
C0021102 (UMLS CUI [3,2])
C0013227 (UMLS CUI [4,1])
C0182537 (UMLS CUI [4,2])
C0021102 (UMLS CUI [4,3])
C1409480 (UMLS CUI [5])
C0562528 (UMLS CUI [6])
C0441319 (UMLS CUI [7])
C0178866 (UMLS CUI [8])
C0337044 (UMLS CUI [9])
C2350609 (UMLS CUI [10])
Illness Significant At risk Study Subject Participation Status | Tendency to fall | Fatigue Excessive | Fatigue General | Frailty General | apprehensiveness Excessive
Item
most of these exclusions also come under the category of significant medical illness. patients for whom participation in the study would, in the opinion of the investigators, cause undue risk or stress for reasons such as tendency to fall, excessive fatigue, general fatigue, general frailty, or excessive apprehensiveness will also be excluded.
boolean
C0221423 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
C1444641 (UMLS CUI [1,3])
C2348568 (UMLS CUI [1,4])
C2830327 (UMLS CUI [2])
C0015672 (UMLS CUI [3,1])
C0442802 (UMLS CUI [3,2])
C0015672 (UMLS CUI [4,1])
C0205246 (UMLS CUI [4,2])
C0424594 (UMLS CUI [5,1])
C0205246 (UMLS CUI [5,2])
C1408583 (UMLS CUI [6,1])
C0442802 (UMLS CUI [6,2])
Childbearing Potential Urine pregnancy test | Pregnancy
Item
a urine sample for the pregnancy test will be obtained from any women of childbearing potential prior to the start of srtms, on the day of the initial interview and signing of the consent form. pregnant women will be excluded from the study.
boolean
C3831118 (UMLS CUI [1,1])
C0430056 (UMLS CUI [1,2])
C0032961 (UMLS CUI [2])
Mentally Disabled Persons | Informed Consent Unable
Item
mentally impaired patients who have no capacity to provide their own consent will be excluded from the study.
boolean
C0079822 (UMLS CUI [1])
C0021430 (UMLS CUI [2,1])
C1299582 (UMLS CUI [2,2])