Non-Small Cell Lung Carcinoma | Standard of Care | Disease Progression | Indication Operative Surgical Procedures | Indication Combined Modality Therapy
Item
patients must have histologically or cytologically confirmed diagnosis of non-small cell lung cancer, must have progressed despite standard therapy and must not be candidates for surgical or combined modality therapy.
boolean
C0007131 (UMLS CUI [1])
C2936643 (UMLS CUI [2])
C0242656 (UMLS CUI [3])
C3146298 (UMLS CUI [4,1])
C0543467 (UMLS CUI [4,2])
C3146298 (UMLS CUI [5,1])
C0009429 (UMLS CUI [5,2])
Age
Item
at least 18 years of age.
boolean
C0001779 (UMLS CUI [1])
Prior Chemotherapy Quantity Neoplasm Metastasis
Item
patients should have received at least one but no more than two prior chemotherapy regimens for metastatic disease. the study chairman or medical monitor will consider extenuating circumstances for patients with more than two such regimens.
boolean
C1514457 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0027627 (UMLS CUI [1,3])
Measurable Disease | Lesion Measurable Quantity | Lesion Measurable Dimensions Quantity | Lesion Measurable Diameter | Measurement technique conventional | Tomography, Spiral Computed
Item
patients must have measurable disease. since the outcome for a patient is to be based on response using recist criteria, the patient must have at least one measurable lesion that can be accurately measured in at least one dimension and fit one of the following criteria: longest diameter 20 mm using conventional techniques or 10 mm with spiral ct scan.
boolean
C1513041 (UMLS CUI [1])
C0221198 (UMLS CUI [2,1])
C1513040 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
C0221198 (UMLS CUI [3,1])
C1513040 (UMLS CUI [3,2])
C0439534 (UMLS CUI [3,3])
C1265611 (UMLS CUI [3,4])
C0221198 (UMLS CUI [4,1])
C1513040 (UMLS CUI [4,2])
C1301886 (UMLS CUI [4,3])
C0242485 (UMLS CUI [5,1])
C0439858 (UMLS CUI [5,2])
C0860888 (UMLS CUI [6])
Life Expectancy
Item
patients must have a life expectancy of more than 3 months.
boolean
C0023671 (UMLS CUI [1])
ECOG performance status
Item
patients should have a performance status of 0 to 1 according to the ecog criteria. however, patients with ecog performance status of 2 may be admitted with approval from the study chairman or medical monitor.
boolean
C1520224 (UMLS CUI [1])
Pregnancy | Breast Feeding | Childbearing Potential Serum pregnancy test negative | Fertility Contraceptive methods
Item
female patients who are pregnant or lactating are ineligible. all females of childbearing potential must have a negative serum pregnancy test within 72 hours of treatment. men and women of childbearing potential must agree to employ adequate contraception to prevent pregnancy while on therapy and for four weeks after the completion of treatment.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0430061 (UMLS CUI [3,2])
C0015895 (UMLS CUI [4,1])
C0700589 (UMLS CUI [4,2])
Informed Consent
Item
patients must have ability to understand and the willingness to sign a written informed consent document.
boolean
C0021430 (UMLS CUI [1])
Rapid disease progression
Item
patients with rapidly progressing disease, as defined by progression within 12 weeks of initiation of the previous regimen.
boolean
C1834700 (UMLS CUI [1])
Investigational New Drugs | Investigational Medical Device
Item
patients receiving any other investigational agents or devices.
boolean
C0013230 (UMLS CUI [1])
C2346570 (UMLS CUI [2])
Allergic Reaction Compound perifosine Similar | Allergic Reaction miltefosine | Allergic Reaction edelfosine
Item
history of allergic reactions attributed to compounds of similar chemical or biologic composition to perifosine (miltefosine or edelfosine).
boolean
C1527304 (UMLS CUI [1,1])
C1706082 (UMLS CUI [1,2])
C0754570 (UMLS CUI [1,3])
C2348205 (UMLS CUI [1,4])
C1527304 (UMLS CUI [2,1])
C0068006 (UMLS CUI [2,2])
C1527304 (UMLS CUI [3,1])
C0044549 (UMLS CUI [3,2])
Illness Uncontrolled | Communicable Diseases | Mental disorder Protocol Compliance Limited | social situation Protocol Compliance Limited
Item
uncontrolled intercurrent illness including, but not limited to, ongoing or active infection and psychiatric illness/social situations that would limit compliance with study requirements.
boolean
C0221423 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0009450 (UMLS CUI [2])
C0004936 (UMLS CUI [3,1])
C0525058 (UMLS CUI [3,2])
C0439801 (UMLS CUI [3,3])
C0748872 (UMLS CUI [4,1])
C0525058 (UMLS CUI [4,2])
C0439801 (UMLS CUI [4,3])
Antiretroviral therapy Combined HIV Seropositivity | Pharmacokinetic interaction Related perifosine
Item
hiv-positive patients receiving combination anti-retroviral therapy are excluded from the study because of possible pharmacokinetic interactions with perifosine.
boolean
C1963724 (UMLS CUI [1,1])
C0205195 (UMLS CUI [1,2])
C0019699 (UMLS CUI [1,3])
C1868980 (UMLS CUI [2,1])
C0439849 (UMLS CUI [2,2])
C0754570 (UMLS CUI [2,3])
Angina, Unstable | Angina Pectoris | Myocardial Infarction Recent | Congestive heart failure | New York Heart Association Classification
Item
patients with a history of unstable or newly diagnosed angina pectoris, recent myocardial infarction (within 6 months of enrollment) or new york heart assoc. class ii-iv congestive heart failure.
boolean
C0002965 (UMLS CUI [1])
C0002962 (UMLS CUI [2])
C0027051 (UMLS CUI [3,1])
C0332185 (UMLS CUI [3,2])
C0018802 (UMLS CUI [4])
C1275491 (UMLS CUI [5])