Clinical Trial Eligibility Criteria Fulfill
Item
all subjects must fulfill the following criteria to be eligible for study admission:
boolean
C1516637 (UMLS CUI [1,1])
C1550543 (UMLS CUI [1,2])
Age
Item
subjects are of age 18 years and above
boolean
C0001779 (UMLS CUI [1])
Nasopharyngeal carcinoma | Biopsy | WHO performance status scale
Item
biopsy proven nasopharyngeal carcinoma – who type 3
boolean
C2931822 (UMLS CUI [1])
C0005558 (UMLS CUI [2])
C1298650 (UMLS CUI [3])
Neoplasm Amenable Biopsy
Item
must have tumor which is accessible to biopsy
boolean
C0027651 (UMLS CUI [1,1])
C3900053 (UMLS CUI [1,2])
C0005558 (UMLS CUI [1,3])
Lesion Localized Nasal sinus | Endoscopy
Item
for patients with disease localized to the pns, the lesion must be visualized by endoscopy
boolean
C0221198 (UMLS CUI [1,1])
C0392752 (UMLS CUI [1,2])
C0030471 (UMLS CUI [1,3])
C0014245 (UMLS CUI [2])
Neoplasm Metastasis | Disease Amenable Paranasal biopsy | treatment need
Item
subjects with metastatic disease with disease accessible to biopsy in the pns if they are deemed by their treating physicians not to require treatment for at least two weeks.
boolean
C0027627 (UMLS CUI [1])
C0012634 (UMLS CUI [2,1])
C3900053 (UMLS CUI [2,2])
C0857438 (UMLS CUI [2,3])
C0815189 (UMLS CUI [3])
ECOG performance status
Item
an ecog performance status of 0–2
boolean
C1520224 (UMLS CUI [1])
Childbearing Potential Sex Behavior Pregnancy test negative
Item
for sexually active women of child-bearing potential, negative pregnancy test within 14 days of enrolling on trial
boolean
C3831118 (UMLS CUI [1,1])
C0036864 (UMLS CUI [1,2])
C0427780 (UMLS CUI [1,3])
Informed Consent
Item
must be able to give informed consent
boolean
C0021430 (UMLS CUI [1])
Nasopharyngeal carcinoma Localized | Nasal sinus Lesion | Endoscopy
Item
for patients with localized npc, pns lesions that cannot be visualized by endoscopy
boolean
C2931822 (UMLS CUI [1,1])
C0392752 (UMLS CUI [1,2])
C0030471 (UMLS CUI [2,1])
C0221198 (UMLS CUI [2,2])
C0014245 (UMLS CUI [3])
Disease Amenable Biopsy
Item
patients with disease inaccessible to biopsy
boolean
C0012634 (UMLS CUI [1,1])
C3900053 (UMLS CUI [1,2])
C0005558 (UMLS CUI [1,3])
anaphylaxis | Valproic Acid Exposure to
Item
history of anaphylaxis after exposure to valproic acid
boolean
C0002792 (UMLS CUI [1])
C0042291 (UMLS CUI [2,1])
C0332157 (UMLS CUI [2,2])
Liver Dysfunction | Serum total bilirubin measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement
Item
hepatic dysfunction as defined by total bilirubin 1.0x upper limit of normal. ast (sgot) and alt (sgpt) 3x upper limit of normal
boolean
C0086565 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0201899 (UMLS CUI [3])
C0201836 (UMLS CUI [4])
Hemoglobin | Absolute neutrophil count | Platelet Count measurement
Item
hemoglobin 8g/dl, absolute neutrophil count 1500 cells/mm, and platelet count 100,000 /mm
boolean
C0019046 (UMLS CUI [1])
C0948762 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
Creatinine measurement, serum
Item
creatinine 3x upper limit of normal
boolean
C0201976 (UMLS CUI [1])
Prothrombin time abnormal | Abnormal partial thromboplastin time (PTT)
Item
pt/ptt blood test result not within normal range
boolean
C0580412 (UMLS CUI [1])
C4062448 (UMLS CUI [2])
Anticonvulsant Patient need for | Valproic Acid | Valproate
Item
patients who require treatment with an anticonvulsant besides valproic acid during the course of valproate prescribed by the protocol
boolean
C0003286 (UMLS CUI [1,1])
C0686904 (UMLS CUI [1,2])
C0042291 (UMLS CUI [2])
C0080356 (UMLS CUI [3])
ECOG performance status
Item
ecog performance status 3-4
boolean
C1520224 (UMLS CUI [1])
Pregnancy | Breast Feeding | Childbearing Potential Sex Behavior Contraceptive methods
Item
patients who are pregnant or breast feeding (sexually active women of childbearing potential must use contraception during course of therapy and within 4 weeks of completion of trial)
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0036864 (UMLS CUI [3,2])
C0700589 (UMLS CUI [3,3])
Study Subject Participation Status | Operative Surgical Procedures
Item
participation in another clinical trial involving therapeutic intervention within 4 weeks of enrollment.
boolean
C2348568 (UMLS CUI [1])
C0543467 (UMLS CUI [2])