Age
Item
age 18-55
boolean
C0001779 (UMLS CUI [1])
Multiple Sclerosis, Relapsing-Remitting
Item
relapsing-remitting multiple sclerosis (rrms)
boolean
C0751967 (UMLS CUI [1])
Avonex
Item
avonex therapy for 6 months prior continuous
boolean
C0594372 (UMLS CUI [1])
Avonex | Relapse Rate Annual
Item
annualized relapse rate >2 during avonex therapy
boolean
C0594372 (UMLS CUI [1])
C0035020 (UMLS CUI [2,1])
C1521828 (UMLS CUI [2,2])
C0332181 (UMLS CUI [2,3])
Relapse Most Recent
Item
most recent relapse within 60 days of baseline
boolean
C0035020 (UMLS CUI [1,1])
C1513491 (UMLS CUI [1,2])
EDSS
Item
entry expanded disability status scale (edss) 1.5-4.5
boolean
C0451246 (UMLS CUI [1])
Gadolinium-Enhancing Lesion | Magnetic Resonance Imaging
Item
one or more gadolinium (gd+) mri lesions on a baseline mri
boolean
C1333400 (UMLS CUI [1])
C0024485 (UMLS CUI [2])
Immunomodulation | Therapeutic immunosuppression | Avonex | Glucocorticoids Relapse Clinical
Item
no history of immune modulator or immunosuppressant therapy used in combination with avonex (other then gsc administer for clinical relapses)
boolean
C1963758 (UMLS CUI [1])
C0021079 (UMLS CUI [2])
C0594372 (UMLS CUI [3])
C0017710 (UMLS CUI [4,1])
C0035020 (UMLS CUI [4,2])
C0205210 (UMLS CUI [4,3])
Study Subject Participation Status | Therapeutic procedure Multiple Sclerosis
Item
not participating in any other study of ms therapeutics
boolean
C2348568 (UMLS CUI [1])
C0087111 (UMLS CUI [2,1])
C0026769 (UMLS CUI [2,2])
Avonex | Serum Neutralizing Antibodies Titer
Item
serum neutralizing antibodies (nabs) titer to avonex <20
boolean
C0594372 (UMLS CUI [1])
C0229671 (UMLS CUI [2,1])
C0475463 (UMLS CUI [2,2])
C0475208 (UMLS CUI [2,3])
Medical condition Affecting Informed Consent | Mental condition Affecting Informed Consent
Item
medical or psychiatric conditions that will affect patients ability to provide informed consent
boolean
C3843040 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0021430 (UMLS CUI [1,3])
C3840291 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C0021430 (UMLS CUI [2,3])
Magnetic Resonance Imaging Receive Unable
Item
inability to undergo mri
boolean
C0024485 (UMLS CUI [1,1])
C1514756 (UMLS CUI [1,2])
C1299582 (UMLS CUI [1,3])
Medical condition Serious Clinical | Laboratory Results Abnormal Significant
Item
clinically serious medical conditions or significantly abnormal labs
boolean
C3843040 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0205210 (UMLS CUI [1,3])
C1254595 (UMLS CUI [2,1])
C0205161 (UMLS CUI [2,2])
C0750502 (UMLS CUI [2,3])
Pharmaceutical Preparations Use | Therapeutic procedure Use
Item
no use of these medications or procedures within six months prior to study:
boolean
C0013227 (UMLS CUI [1,1])
C1524063 (UMLS CUI [1,2])
C0087111 (UMLS CUI [2,1])
C1524063 (UMLS CUI [2,2])
Monoclonal Antibodies | Total Lymphatic Radiation Therapy | systemic steroids | Cytotoxic agent | Immunosuppressive Agents | Mitoxantrone | Cyclophosphamide | Investigational New Drugs
Item
*monoclonal antibodies,total lymphoid radiation,systemic steroids,cytotoxic or immunosuppressive medications such as mitoxantrone or cyclophosphamide or any other investigational drugs
boolean
C0003250 (UMLS CUI [1])
C0086572 (UMLS CUI [2,1])
C0439810 (UMLS CUI [2,2])
C2825233 (UMLS CUI [3])
C0304497 (UMLS CUI [4])
C0021081 (UMLS CUI [5])
C0026259 (UMLS CUI [6])
C0010583 (UMLS CUI [7])
C0013230 (UMLS CUI [8])
Interferon Neutralizing Antibodies Titer
Item
interferon neutralizing antibody titers >20
boolean
C0021747 (UMLS CUI [1,1])
C0475463 (UMLS CUI [1,2])
C0475208 (UMLS CUI [1,3])
Breast Feeding | Pregnancy
Item
no breast feeding or pregnant
boolean
C0006147 (UMLS CUI [1])
C0032961 (UMLS CUI [2])
Systemic disease Affecting patient safety | Systemic disease Affecting Protocol Compliance | Mental condition Affecting patient safety | Mental condition Affecting Protocol Compliance | Disease Affecting patient safety | Disease Affecting Protocol Compliance
Item
no patients with any systemic illness,psychiatric condition or other disorder that would concern safety of patient to complete procedures of protocol
boolean
C0442893 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C1113679 (UMLS CUI [1,3])
C0442893 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C0525058 (UMLS CUI [2,3])
C3840291 (UMLS CUI [3,1])
C0392760 (UMLS CUI [3,2])
C1113679 (UMLS CUI [3,3])
C3840291 (UMLS CUI [4,1])
C0392760 (UMLS CUI [4,2])
C0525058 (UMLS CUI [4,3])
C0012634 (UMLS CUI [5,1])
C0392760 (UMLS CUI [5,2])
C1113679 (UMLS CUI [5,3])
C0012634 (UMLS CUI [6,1])
C0392760 (UMLS CUI [6,2])
C0525058 (UMLS CUI [6,3])
Blood test abnormal
Item
abnormal blood test
boolean
C0854146 (UMLS CUI [1])
Chest X-ray abnormal Clinical Significance
Item
clinically significant abnormality on chest x-ray (cxr)
boolean
C0436503 (UMLS CUI [1,1])
C2826293 (UMLS CUI [1,2])