Multiple Sclerosis | Outpatient | EDSS
Item
multiple sclerosis [ms] subject who was ambulatory (edss of ≤ 5.5)
boolean
C0026769 (UMLS CUI [1])
C0029921 (UMLS CUI [2])
C0451246 (UMLS CUI [3])
Relapsing course Clinical | Disease Progression | Multiple Sclerosis, Relapsing-Remitting | Multiple Sclerosis, Secondary Progressive | Multiple Sclerosis, Progressive Relapsing
Item
exhibiting a relapsing clinical course, with or without progression (relapsing remitting, secondary progressive or progressive relapsing);
boolean
C0205336 (UMLS CUI [1,1])
C0205210 (UMLS CUI [1,2])
C0242656 (UMLS CUI [2])
C0751967 (UMLS CUI [3])
C0751965 (UMLS CUI [4])
C0393666 (UMLS CUI [5])
Multiple Sclerosis
Item
meeting mcdonald's criteria for ms diagnosis;
boolean
C0026769 (UMLS CUI [1])
Relapse Quantity Period
Item
experienced at least 1 relapse over the 1 year preceding the trial or at least 2 relapses over the 2 years preceding the trial;
boolean
C0035020 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C1948053 (UMLS CUI [1,3])
Relapse Onset
Item
no relapse onset in the preceding 60 days prior to randomization;
boolean
C0035020 (UMLS CUI [1,1])
C0332162 (UMLS CUI [1,2])
Stable status Clinical | Corticotropin | systemic steroids
Item
clinically stable during the 30 days prior to randomization, without adrenocorticotrophic hormone [acth] or systemic steroid treatment.
boolean
C0205360 (UMLS CUI [1,1])
C0205210 (UMLS CUI [1,2])
C0001655 (UMLS CUI [2])
C2825233 (UMLS CUI [3])
Cardiovascular Disease Relevant Clinical | Liver disease Relevant Clinical | nervous system disorder Relevant Clinical | Endocrine System Disease Relevant Clinical | Systemic disease Major
Item
clinically relevant cardiovascular, hepatic, neurological, endocrine or other major systemic disease;
boolean
C0007222 (UMLS CUI [1,1])
C2347946 (UMLS CUI [1,2])
C0205210 (UMLS CUI [1,3])
C0023895 (UMLS CUI [2,1])
C2347946 (UMLS CUI [2,2])
C0205210 (UMLS CUI [2,3])
C0027765 (UMLS CUI [3,1])
C2347946 (UMLS CUI [3,2])
C0205210 (UMLS CUI [3,3])
C0014130 (UMLS CUI [4,1])
C2347946 (UMLS CUI [4,2])
C0205210 (UMLS CUI [4,3])
C0442893 (UMLS CUI [5,1])
C0205164 (UMLS CUI [5,2])
Bone Marrow function Impaired Significant
Item
significantly impaired bone marrow function;
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0221099 (UMLS CUI [1,3])
C0750502 (UMLS CUI [1,4])
Pregnancy | Breast Feeding
Item
pregnant or nursing woman;
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Substance Use Disorders
Item
alcohol or drug abuse;
boolean
C0038586 (UMLS CUI [1])
Cladribine | Mitoxantrone | Immunosuppressive Agents | Azathioprine | Cyclophosphamide | Cyclosporine | Methotrexate | MYCOPHENOLATE
Item
use of cladribine, mitoxantrone, or other immunosuppressant agents such as azathioprine, cyclophosphamide, cyclosporin, methotrexate or mycophenolate before enrollment;
boolean
C0092801 (UMLS CUI [1])
C0026259 (UMLS CUI [2])
C0021081 (UMLS CUI [3])
C0004482 (UMLS CUI [4])
C0010583 (UMLS CUI [5])
C0010592 (UMLS CUI [6])
C0025677 (UMLS CUI [7])
C0883242 (UMLS CUI [8])
Condition Preventing Protocol Compliance
Item
any known condition or circumstance that would prevent in the investigator's opinion compliance or completion of the study;
boolean
C0348080 (UMLS CUI [1,1])
C1292733 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])