Age
Item
male or female, 18 to 55 years of age
boolean
C0001779 (UMLS CUI [1])
Multiple sclerosis relapse | Relapse Quantity
Item
diagnosed with relapsing multiple sclerosis, with at least one relapse in the last two years
boolean
C0856120 (UMLS CUI [1])
C0035020 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
Pregnancy, Planned
Item
females must not plan on becoming pregnant
boolean
C0032992 (UMLS CUI [1])
Gender | Postmenopausal state | Female Sterilization | Contraceptive methods
Item
females must either be post-menopausal, surgically incapable of bearing children, or practicing an acceptable method of birth control and willing to continue birth control until 30 days after the last dose of study drug
boolean
C0079399 (UMLS CUI [1])
C0232970 (UMLS CUI [2])
C0015787 (UMLS CUI [3])
C0700589 (UMLS CUI [4])
Gender | Fertilization intended Partner | Contraceptive methods Partner
Item
males must not intend to impregnate a partner during the study or for 30 days after the study and must also practice acceptable birth control with their partners
boolean
C0079399 (UMLS CUI [1])
C0015914 (UMLS CUI [2,1])
C1283828 (UMLS CUI [2,2])
C0682323 (UMLS CUI [2,3])
C0700589 (UMLS CUI [3,1])
C0682323 (UMLS CUI [3,2])
Chronic disease of immune system Significant | Multiple Sclerosis
Item
significant long-lasting disease of the immune system other than multiple sclerosis
boolean
C1290894 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
C0026769 (UMLS CUI [2])
Disease | Heart Disease | Liver disease | Kidney Disease | Severe asthma | Malignant Neoplasms | Brain Disease Advanced | Spinal Cord Disease Advanced
Item
past or current medical disease (heart, liver, kidney, etc.) including severe asthma, cancer or advancing brain or spinal cord disorder
boolean
C0012634 (UMLS CUI [1])
C0018799 (UMLS CUI [2])
C0023895 (UMLS CUI [3])
C0022658 (UMLS CUI [4])
C0581126 (UMLS CUI [5])
C0006826 (UMLS CUI [6])
C0006111 (UMLS CUI [7,1])
C0205179 (UMLS CUI [7,2])
C0037928 (UMLS CUI [8,1])
C0205179 (UMLS CUI [8,2])
Communicable Disease Long-term | HIV Infection | Hepatitis B | Hepatitis C
Item
known or suspected long-lasting infectious disease including hiv, hepatitis b, or hepatitis c
boolean
C0009450 (UMLS CUI [1,1])
C0443252 (UMLS CUI [1,2])
C0019693 (UMLS CUI [2])
C0019163 (UMLS CUI [3])
C0019196 (UMLS CUI [4])
Steroids | Hormone Therapy | MRI Scan Pre-study
Item
treatment with certain steroid or hormone medications within 30 days before the pre-study mri scan
boolean
C0038317 (UMLS CUI [1])
C0279025 (UMLS CUI [2])
C0917711 (UMLS CUI [3,1])
C1527048 (UMLS CUI [3,2])
Immunosuppressive Agents | MRI Scan Pre-study
Item
treatment with other medications that suppress the immune system within 6 months before the pre-study mri scan
boolean
C0021081 (UMLS CUI [1])
C0917711 (UMLS CUI [2,1])
C1527048 (UMLS CUI [2,2])
Therapeutic procedure Illicit | Pharmaceutical Preparations Illicit
Item
certain treatments and medications are not allowed
boolean
C0087111 (UMLS CUI [1,1])
C0332266 (UMLS CUI [1,2])
C0013227 (UMLS CUI [2,1])
C0332266 (UMLS CUI [2,2])
Laboratory Procedures Eligibility Determination | Tests Eligibility Determination
Item
laboratory and other tests will be performed to determine further eligibility
boolean
C0022885 (UMLS CUI [1,1])
C0013893 (UMLS CUI [1,2])
C0392366 (UMLS CUI [2,1])
C0013893 (UMLS CUI [2,2])
substance abuse
Item
history of drug or alcohol abuse in the last year
boolean
C0038586 (UMLS CUI [1])
Medical condition Resulting in Risk Study Subject Participation Status | Mental condition Resulting in Risk Study Subject Participation Status
Item
history of medical or psychiatric condition that could pose a risk for participation in the study
boolean
C3843040 (UMLS CUI [1,1])
C0332294 (UMLS CUI [1,2])
C0035647 (UMLS CUI [1,3])
C2348568 (UMLS CUI [1,4])
C3840291 (UMLS CUI [2,1])
C0332294 (UMLS CUI [2,2])
C0035647 (UMLS CUI [2,3])
C2348568 (UMLS CUI [2,4])
Pregnancy | Breast Feeding
Item
females who are pregnant or breast feeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Study Subject Participation Status | Investigational New Drugs
Item
participation in any other trial of an investigational agent within 90 days before the start of the study
boolean
C2348568 (UMLS CUI [1])
C0013230 (UMLS CUI [2])
Compliance behavior Limited
Item
history of not following instructions with past therapy.
boolean
C1321605 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])