Multiple Myeloma
Item
diagnosis of mm according to the swog criteria (annex 1)
boolean
C0026764 (UMLS CUI [1])
Multiple Myeloma untreated | Therapeutic radiology procedure Localized
Item
previously untreated (localized radiotherapy is allowed)
boolean
C0026764 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C1522449 (UMLS CUI [2,1])
C0392752 (UMLS CUI [2,2])
Multiple Myeloma Symptomatic | Staging | Osteolytic lesion Symptomatic
Item
symptomatic mm stage ii or iii according to durie-salmon staging system (annex 2) or stage i with one symptomatic osteolytic lesion
boolean
C0026764 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
C0332305 (UMLS CUI [2])
C0302313 (UMLS CUI [3,1])
C0231220 (UMLS CUI [3,2])
Serum paraprotein measurement | Urine paraprotein measurement
Item
with measurable levels of paraprotein in the serum (> 1g/dl) or in the urine (> 0.2g/24h)
boolean
C0585639 (UMLS CUI [1])
C0585640 (UMLS CUI [2])
Age
Item
age < 75 years
boolean
C0001779 (UMLS CUI [1])
Informed Consent
Item
able to understand and to given an informed consent
boolean
C0021430 (UMLS CUI [1])
Childbearing Potential Lacking | Urine pregnancy test negative | Childbearing Potential Contraceptive methods
Item
male, female without childbearing potential or negative urine pregnancy test within 72 hours prior to beginning the treatment. women of childbearing potential must be following adequate contraceptive measures.
boolean
C3831118 (UMLS CUI [1,1])
C0332268 (UMLS CUI [1,2])
C0430057 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
Sepsis | Antibiotics Spectrum broad | Antibiotics Organism Specific | Fever | Vital signs Stable | Antibiotics | Velcade | Dexamethasone
Item
no active systemic infection. in the presence of any active systemic infection, adequate broad-spectrum or organism-specific antibiotic coverage must be administered. patients must be a febrile with stable vital signs while receiving antibiotics for at least 48 hours prior to beginning the treatment with velcade plus dexamethasone.
boolean
C0243026 (UMLS CUI [1])
C0003232 (UMLS CUI [2,1])
C2827424 (UMLS CUI [2,2])
C0332464 (UMLS CUI [2,3])
C0003232 (UMLS CUI [3,1])
C0029235 (UMLS CUI [3,2])
C0205369 (UMLS CUI [3,3])
C0015967 (UMLS CUI [4])
C0518766 (UMLS CUI [5,1])
C0205360 (UMLS CUI [5,2])
C0003232 (UMLS CUI [6])
C1174739 (UMLS CUI [7])
C0011777 (UMLS CUI [8])
Life Expectancy
Item
life expectancy < 2 months
boolean
C0023671 (UMLS CUI [1])
ECOG performance status
Item
ecog performance status > 2 (annex 3)
boolean
C1520224 (UMLS CUI [1])
Amyloidosis
Item
proven amyloidosis
boolean
C0002726 (UMLS CUI [1])
HIV Seropositivity
Item
positive hiv serology
boolean
C0019699 (UMLS CUI [1])
Mental disorders Severe Disease antecedent
Item
antecedents of severe psychiatric disease
boolean
C0004936 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0683336 (UMLS CUI [1,3])
Diabetes Mellitus Severe | Medical contraindication Adrenal Cortex Hormones High dose
Item
severe diabetes contraindicating the use of high-dose corticoïds
boolean
C0011849 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C1301624 (UMLS CUI [2,1])
C0001617 (UMLS CUI [2,2])
C0444956 (UMLS CUI [2,3])
Peripheral Neuropathy | CTCAE Grades
Item
> nci grade 2 peripheral neuropathy (annex iv)
boolean
C0031117 (UMLS CUI [1])
C1516728 (UMLS CUI [2])
Serum Test Result Biochemical
Item
serum biochemical values as follow
boolean
C0229671 (UMLS CUI [1,1])
C0456984 (UMLS CUI [1,2])
C0205474 (UMLS CUI [1,3])
Creatinine measurement, serum
Item
creatinin level > 200mmol/l
boolean
C0201976 (UMLS CUI [1])
Serum total bilirubin measurement | Transaminases increased | Gamma glutamyl transferase measurement
Item
bilirubin, transaminases or ggt > 3 the upper normal limit
boolean
C1278039 (UMLS CUI [1])
C0438717 (UMLS CUI [2])
C0202035 (UMLS CUI [3])
Investigational New Drugs
Item
use of any experimental drugs within 30 days of baseline
boolean
C0013230 (UMLS CUI [1])