Clear Cell Renal Cell Carcinoma Metastatic
Item
histologically or cytologically confirmed metastatic clear cell renal cell cancer;
boolean
C0279702 (UMLS CUI [1,1])
C0036525 (UMLS CUI [1,2])
Measurable Disease Linear Quantity
Item
at least one lesion that can be accurately measured in at least one dimension;
boolean
C1513041 (UMLS CUI [1,1])
C0205132 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
Kinase Inhibitors Against Malignant Neoplasms | VEGF Signaling Pathway inhibitors
Item
patients must not have been treated with prior anti-timor kinase inhibitors or vegf pathway inhibitors;
boolean
C1152564 (UMLS CUI [1,1])
C0521124 (UMLS CUI [1,2])
C0006826 (UMLS CUI [1,3])
C2984329 (UMLS CUI [2,1])
C0243077 (UMLS CUI [2,2])
Age
Item
age 18 and older;
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
ecog performance status 0-2;
boolean
C1520224 (UMLS CUI [1])
Blood pressure finding Quantity
Item
blood pressure higher than 140/90 on 2 separate occasions not more than 6 weeks prior to enrollment and not less than 24 hours apart;
boolean
C1271104 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
organ function | Serum total bilirubin measurement | Aspartate aminotransferase measurement | Creatinine measurement, serum
Item
normal organ function: total bilirubin less than upper limit of normal, ast less than 2.5 x upper limit of normal, creatinine less than 2.8 mg/dl;
boolean
C0678852 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0201899 (UMLS CUI [3])
C0201976 (UMLS CUI [4])
Childbearing Potential Contraceptive methods | Gender Contraceptive methods
Item
women of child-bearing potential and men must agree to use adequate contraception prior to study entry and for the duration of study participation;
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0079399 (UMLS CUI [2,1])
C0700589 (UMLS CUI [2,2])
Informed Consent
Item
ability to understand and the willingness to sign a written informed consent document.
boolean
C0021430 (UMLS CUI [1])
Chemotherapy | Therapeutic radiology procedure
Item
chemotherapy or radiotherapy within 4 weeks prior to entering the study;
boolean
C0392920 (UMLS CUI [1])
C1522449 (UMLS CUI [2])
Investigational New Drugs
Item
any other investigational agents;
boolean
C0013230 (UMLS CUI [1])
Metastatic malignant neoplasm to brain
Item
known brain metastases;
boolean
C0220650 (UMLS CUI [1])
Illness Uncontrolled | Communicable Diseases | Symptomatic congestive heart failure | Angina, Unstable | Cardiac Arrhythmia | Mental disorders Compliance behavior Limited | social situation Compliance behavior Limited
Item
uncontrolled intercurrent illness including ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements;
boolean
C0221423 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0009450 (UMLS CUI [2])
C0742758 (UMLS CUI [3])
C0002965 (UMLS CUI [4])
C0003811 (UMLS CUI [5])
C0004936 (UMLS CUI [6,1])
C1321605 (UMLS CUI [6,2])
C0439801 (UMLS CUI [6,3])
C0748872 (UMLS CUI [7,1])
C1321605 (UMLS CUI [7,2])
C0439801 (UMLS CUI [7,3])
Pregnancy
Item
pregnancy.
boolean
C0032961 (UMLS CUI [1])