Carcinoma breast stage IV | Breast cancer recurrent
Item
histologic or cytologic diagnosis of stage iv or recurrent breast cancer.
boolean
C0278488 (UMLS CUI [1])
C0278493 (UMLS CUI [2])
Chemotherapy, Adjuvant | Chemotherapy Carcinoma breast stage IV | Anthracyclines | taxane | capecitabine
Item
previous anthracycline and/or taxane and/or capecitabine chemotherapy in adjuvant and metastatic setting.
boolean
C0085533 (UMLS CUI [1])
C3665472 (UMLS CUI [2,1])
C0278488 (UMLS CUI [2,2])
C0282564 (UMLS CUI [3])
C0215136 (UMLS CUI [4])
C0671970 (UMLS CUI [5])
Hormone Therapy Adjuvant | Hormone Therapy Carcinoma breast stage IV
Item
previous hormonal therapy in adjuvant and metastatic setting.
boolean
C0279025 (UMLS CUI [1,1])
C1522673 (UMLS CUI [1,2])
C0279025 (UMLS CUI [2,1])
C0278488 (UMLS CUI [2,2])
prior radiation therapy | Measurable Disease
Item
prior radiation therapy is allowed as long as the irradiated area is not the only source of measurable disease.
boolean
C0279134 (UMLS CUI [1])
C1513041 (UMLS CUI [2])
cancer treatment | Therapeutic radiology procedure | Immunotherapy
Item
no other forms of cancer therapy, such as radiation, immunotherapy for at least 3 weeks before the enrollment in study.
boolean
C0920425 (UMLS CUI [1])
C1522449 (UMLS CUI [2])
C0021083 (UMLS CUI [3])
ECOG performance status
Item
performance status of 0, 1, 2 on the ecog criteria.
boolean
C1520224 (UMLS CUI [1])
Measurable Disease Clinical | Measurable Lesion Linear | Circumscribed lesion | Plain x-ray | X-Ray Computed Tomography | Magnetic Resonance Imaging | Physical Examination | Lesion size
Item
clinically measurable disease, defined as unidimensionally measurable lesions with clearly defined margins on x-ray, ct scan, mri or physical examination. lesions serving as measurable disease must be at least 1cm by 1cm, as defined by x-ray, ct scan, mri,or physical examination.
boolean
C1513041 (UMLS CUI [1,1])
C0205210 (UMLS CUI [1,2])
C1513041 (UMLS CUI [2,1])
C0205132 (UMLS CUI [2,2])
C1268666 (UMLS CUI [3])
C1306645 (UMLS CUI [4])
C0040405 (UMLS CUI [5])
C0024485 (UMLS CUI [6])
C0031809 (UMLS CUI [7])
C0449453 (UMLS CUI [8])
Life Expectancy Estimated
Item
estimated life expectancy of at least 12 weeks.
boolean
C0023671 (UMLS CUI [1,1])
C0750572 (UMLS CUI [1,2])
Compliance behavior Follow-up
Item
patient compliance that allow adequate follow-up.
boolean
C1321605 (UMLS CUI [1,1])
C1522577 (UMLS CUI [1,2])
Hematologic function | White Blood Cell Count procedure | Platelet Count measurement | Liver function | Serum total bilirubin measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Renal function | Creatinine measurement, serum
Item
adequate hematologic (wbc count3,000/mm3, platelet count100,000/mm3), hepatic (bilirubin level1.5 mg/dl, ast, alt3xuln), and renal (creatinine concentration 1.5 mg/dl) function.
boolean
C0221130 (UMLS CUI [1])
C0023508 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
C0232741 (UMLS CUI [4])
C1278039 (UMLS CUI [5])
C0201899 (UMLS CUI [6])
C0201836 (UMLS CUI [7])
C0232804 (UMLS CUI [8])
C0201976 (UMLS CUI [9])
Informed Consent | Informed Consent Relative
Item
informed consent from patient or patient's relative.
boolean
C0021430 (UMLS CUI [1])
C0021430 (UMLS CUI [2,1])
C0080103 (UMLS CUI [2,2])
Gender | Age
Item
females at least 18 years of age.
boolean
C0079399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Childbearing Potential Contraceptive methods
Item
childbearing women should use non-hormonal contraceptive method.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Prior Chemotherapy Quantity Breast cancer recurrent | Prior Chemotherapy Quantity Carcinoma breast stage IV
Item
previous chemotherapy > 3 for recurrent or stage iv disease second primary malignancy (except in situ carcinoma of the cervix or adequately treated basal cell carcinoma of the skin or prior malignancy treated more than 5 years ago without recurrence).
boolean
C1514457 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0278493 (UMLS CUI [1,3])
C1514457 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0278488 (UMLS CUI [2,3])
Second Primary Cancers | Carcinoma in situ of uterine cervix | Basal cell carcinoma Treated | Malignant Neoplasm Treated
Item
second primary malignancy (except in situ carcinoma of the cervix or adequately treated basal cell carcinoma of the skin or prior malignancy treated more than 5 years ago without recurrence).
boolean
C0751623 (UMLS CUI [1])
C0851140 (UMLS CUI [2])
C0007117 (UMLS CUI [3,1])
C1522326 (UMLS CUI [3,2])
C0006826 (UMLS CUI [4,1])
C1522326 (UMLS CUI [4,2])