HER2/Neu Overexpression | Fluorescent in Situ Hybridization | Immunohistochemistry
Item
her-2/neu overexpression assessed by fish test or with immunohistochemical methods: dako(the result must be 3+ with dakotest); if the immunohistochemical test results 2+
boolean
C1512413 (UMLS CUI [1,1])
C1514559 (UMLS CUI [1,2])
C0162789 (UMLS CUI [2])
C0021044 (UMLS CUI [3])
Fluorescent in Situ Hybridization Positive
Item
it is needed a positive fish test
boolean
C0162789 (UMLS CUI [1,1])
C1514241 (UMLS CUI [1,2])
Gender | Age
Item
female < 70yrs
boolean
C0079399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Breast Carcinoma
Item
histologically or cytologically proven breast cancer.
boolean
C0678222 (UMLS CUI [1])
Carcinoma breast stage IV | Locally advanced breast cancer | TNM clinical staging
Item
metastatic or locally advanced breast cancer (clinical stage: iii-iv)
boolean
C0278488 (UMLS CUI [1])
C3495949 (UMLS CUI [2])
C3258246 (UMLS CUI [3])
Hematologic function | Liver function | Renal function | Cardiac function | Echocardiography | FEV1
Item
adequate hematological, hepatic, renal and cardiac function, the latter confirmed by echocardiography with fevs ≥50%
boolean
C0221130 (UMLS CUI [1])
C0232741 (UMLS CUI [2])
C0232804 (UMLS CUI [3])
C0232164 (UMLS CUI [4])
C0013516 (UMLS CUI [5])
C0429706 (UMLS CUI [6])
Chemotherapy, Adjuvant | Doxorubicin Cumulative Dose | Epirubicin Cumulative Dose
Item
prior adjuvant chemotherapy if doxorubicin total dose ≤300 mg/m2, epirubicin total dose ≤450 mg/m2
boolean
C0085533 (UMLS CUI [1])
C0013089 (UMLS CUI [2,1])
C2986497 (UMLS CUI [2,2])
C0014582 (UMLS CUI [3,1])
C2986497 (UMLS CUI [3,2])
Heart Diseases
Item
history of cardiopathy
boolean
C0018799 (UMLS CUI [1])
Liver disease Severe | Kidney Disease Severe
Item
severe hepatic and renal diseases
boolean
C0023895 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0022658 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
Metastatic malignant neoplasm to brain
Item
brain metastases as the only parameter of disease
boolean
C0220650 (UMLS CUI [1])
Medical contraindication Adrenal Cortex Hormones Premedication
Item
contraindication to the use of corticosteroids as premedication
boolean
C1301624 (UMLS CUI [1,1])
C0001617 (UMLS CUI [1,2])
C0033045 (UMLS CUI [1,3])
Communicable Diseases
Item
acute infectious diseases
boolean
C0009450 (UMLS CUI [1])
Diabetes Mellitus, Insulin-Dependent
Item
insulin-dependent diabetes
boolean
C0011854 (UMLS CUI [1])
Malignant Neoplasms | Basal cell carcinoma Treated Adequate | Carcinoma in situ of uterine cervix Treated Adequate
Item
history of other cancers except for adequately treated basal cell skin cancer or in situ carcinoma of the cervix
boolean
C0006826 (UMLS CUI [1])
C0007117 (UMLS CUI [2,1])
C1522326 (UMLS CUI [2,2])
C0205411 (UMLS CUI [2,3])
C0851140 (UMLS CUI [3,1])
C1522326 (UMLS CUI [3,2])
C0205411 (UMLS CUI [3,3])
cancer treatment
Item
concurrent treatment with any other cancer therapy
boolean
C0920425 (UMLS CUI [1])