Lymphoma, Non-Hodgkin
Item
histological or cytological diagnosis of non-hodgkin's lymphoma
boolean
C0024305 (UMLS CUI [1])
Disease Localized Central Nervous System | treatment failure
Item
disease exclusively localised into the cns at first diagnosis and failure
boolean
C0012634 (UMLS CUI [1,1])
C0392752 (UMLS CUI [1,2])
C3714787 (UMLS CUI [1,3])
C0162643 (UMLS CUI [2])
Progressive Disease | Recurrent disease
Item
progressive or recurrent disease
boolean
C1335499 (UMLS CUI [1])
C0277556 (UMLS CUI [2])
Methotrexate High dose | Chemotherapy | Therapeutic radiology procedure
Item
previous treatment with hdmtx containing cht and/or rt
boolean
C0025677 (UMLS CUI [1,1])
C0444956 (UMLS CUI [1,2])
C0392920 (UMLS CUI [2])
C1522449 (UMLS CUI [3])
Target Lesion Quantity | Measurable Disease 2-Dimensional
Item
presence of at least one target lesion, bidimensionally measurable
boolean
C2986546 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C1513041 (UMLS CUI [2,1])
C1705052 (UMLS CUI [2,2])
Age
Item
age 18 - 75 years
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
ecog performance status < 3 (appendix 1).
boolean
C1520224 (UMLS CUI [1])
HIV | Immunologic Deficiency Syndromes
Item
no known hiv disease or immunodeficiency
boolean
C0019682 (UMLS CUI [1])
C0021051 (UMLS CUI [2])
Hepatitis B surface antigen negative | Hepatitis C Antibodies Negative
Item
hbsag-negative and ab anti-hcv-negative patients.
boolean
C0919711 (UMLS CUI [1])
C0166049 (UMLS CUI [2,1])
C1513916 (UMLS CUI [2,2])
Bone Marrow function | Platelet Count measurement | Hemoglobin | Absolute neutrophil count
Item
adequate bone marrow function (plt > 100000 mm3, hb > 9 g/dl, anc > 2.000 mm3)
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0032181 (UMLS CUI [2])
C0019046 (UMLS CUI [3])
C0948762 (UMLS CUI [4])
Renal function | Creatinine measurement, serum
Item
adequate renal function (serum creatinine < 2 times unl)
boolean
C0232804 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
Liver function | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Serum total bilirubin measurement | Alkaline phosphatase measurement
Item
adequate hepatic function (sgot/sgpt < 3 times unl, bilirubin and alkaline phosphatase < 2 times unl)
boolean
C0232741 (UMLS CUI [1])
C0201899 (UMLS CUI [2])
C0201836 (UMLS CUI [3])
C1278039 (UMLS CUI [4])
C0201850 (UMLS CUI [5])
Cardiac function Ventricular Ejection Fraction
Item
adequate cardiac function (vef ≥ 50%)
boolean
C0232164 (UMLS CUI [1,1])
C0042508 (UMLS CUI [1,2])
Condition Affecting Protocol Compliance
Item
absence of any psycological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule
boolean
C0348080 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])
Pregnancy | Breast Feeding | Childbearing Potential Sex Behavior Contraceptive methods
Item
non-pregnant and non-lactating status for female patients. adequate contraceptive measures during study participation for sexually active patients of childbearing potential.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0036864 (UMLS CUI [3,2])
C0700589 (UMLS CUI [3,3])
Malignant Neoplasms | Carcinoma in situ of uterine cervix Cure of disease Surgical | Basal cell carcinoma | Squamous cell carcinoma of skin
Item
no previous or concurrent malignancies at other sites with the exception of surgically cured carcinoma in-site of the cervix and basal or squamous cell carcinoma of the skin and of other neoplasms without evidence of disease since at least 5 years.
boolean
C0006826 (UMLS CUI [1])
C0851140 (UMLS CUI [2,1])
C0679252 (UMLS CUI [2,2])
C0543467 (UMLS CUI [2,3])
C0007117 (UMLS CUI [3])
C0553723 (UMLS CUI [4])
Investigational New Drugs
Item
no concurrent treatment with other experimental drugs.
boolean
C0013230 (UMLS CUI [1])
Informed Consent
Item
informed consent signed by the patient before registration
boolean
C0021430 (UMLS CUI [1])