Lymphoma, Non-Hodgkin
Item
1. histological or cytological diagnosis of non-hodgkin's lymphoma.
boolean
C0024305 (UMLS CUI [1])
Sample obtained Stereotactic Biopsy | Sample obtained Surgical biopsy | Sample obtained Cerebrospinal Fluid Cytology procedure | Sample obtained Vitrectomy
Item
2. diagnostic sample obtained by stereotactic or surgical biopsy, csf cytology examination or vitrectomy.
boolean
C1277697 (UMLS CUI [1,1])
C1711202 (UMLS CUI [1,2])
C1277697 (UMLS CUI [2,1])
C0370003 (UMLS CUI [2,2])
C0565118 (UMLS CUI [2,3])
C1277697 (UMLS CUI [3,1])
C0007806 (UMLS CUI [3,2])
C1305671 (UMLS CUI [3,3])
C1277697 (UMLS CUI [4,1])
C0042903 (UMLS CUI [4,2])
Disease Localized Central Nervous System | Disease Localized Cranial Nerves | Disease Localized Eyes
Item
3. disease exclusively localized into the central nervous system, cranial nerves or eyes.
boolean
C0012634 (UMLS CUI [1,1])
C0392752 (UMLS CUI [1,2])
C3714787 (UMLS CUI [1,3])
C0012634 (UMLS CUI [2,1])
C0392752 (UMLS CUI [2,2])
C0010268 (UMLS CUI [2,3])
C0012634 (UMLS CUI [3,1])
C0392752 (UMLS CUI [3,2])
C0015392 (UMLS CUI [3,3])
Patients untreated | Steroids alone
Item
4. untreated patients (patients treated with steroids alone are eligible).
boolean
C0030705 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C0038317 (UMLS CUI [2,1])
C0205171 (UMLS CUI [2,2])
Measurable lesion Quantity
Item
5. at least one measurable lesion.
boolean
C1513041 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
Age
Item
6. age 18 - 75 years.
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
7. ecog performance status < 3
boolean
C1520224 (UMLS CUI [1])
Hepatitis B surface antigen negative | Hepatitis C Antibodies Serologic Negative
Item
8. hbsag-negative and ab anti-hcv-negative serologic status.
boolean
C0919711 (UMLS CUI [1])
C0166049 (UMLS CUI [2,1])
C0205473 (UMLS CUI [2,2])
C1513916 (UMLS CUI [2,3])
HIV | Immunologic Deficiency Syndromes
Item
9. no known hiv disease or immunodeficiency.
boolean
C0019682 (UMLS CUI [1])
C0021051 (UMLS CUI [2])
Bone Marrow function | Platelet Count measurement | Hemoglobin | Absolute neutrophil count | Renal function | Creatinine clearance measurement | Cardiac function | Ventricular Ejection Fraction | Liver function | Serum total bilirubin measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Gamma glutamyl transferase measurement
Item
10. adequate bone marrow (plt > 100000 mm3, hb ≥ 9 g/dl, anc ≥ 2.000 mm3), renal (creatinine clearance ≥ 60 ml/min), cardiac (vef ≥ 50%), and hepatic function (total serum bilirubin < 3 mg/dl, ast/alt and ggt < 2 per upper normal limit value).
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0032181 (UMLS CUI [2])
C0019046 (UMLS CUI [3])
C0948762 (UMLS CUI [4])
C0232804 (UMLS CUI [5])
C0373595 (UMLS CUI [6])
C0232164 (UMLS CUI [7])
C0042508 (UMLS CUI [8])
C0232741 (UMLS CUI [9])
C1278039 (UMLS CUI [10])
C0201899 (UMLS CUI [11])
C0201836 (UMLS CUI [12])
C0202035 (UMLS CUI [13])
Malignant Neoplasms | Cervical intraepithelial neoplasia grade 1 Cure of disease surgical | Skin carcinoma Localized | Lymphoma Previous
Item
11. no previous or concurrent malignancies with the exception of surgically cured cervical intraepithelial neoplasia type 1 (cin1) or localized non-melanomatous skin cancer and of other cancers without evidence of disease since at least 5 years (patients with a previous lymphoma diagnosis will be excluded).
boolean
C0006826 (UMLS CUI [1])
C0349458 (UMLS CUI [2,1])
C0679252 (UMLS CUI [2,2])
C0543467 (UMLS CUI [2,3])
C0699893 (UMLS CUI [3,1])
C0392752 (UMLS CUI [3,2])
C0024299 (UMLS CUI [4,1])
C0205156 (UMLS CUI [4,2])
Condition Affecting Protocol Compliance
Item
12. absence of any familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule.
boolean
C0348080 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])
Pregnancy | Breast Feeding | Childbearing Potential Sex Behavior Contraceptive methods
Item
13. non-pregnant and non-lactating status for female patients. adequate contraceptive measures during study participation for sexually active patients of childbearing potential.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0036864 (UMLS CUI [3,2])
C0700589 (UMLS CUI [3,3])
Investigational New Drugs
Item
14. no concurrent treatment with other experimental drugs.
boolean
C0013230 (UMLS CUI [1])
Informed Consent
Item
15. informed consent signed by the patient before registration
boolean
C0021430 (UMLS CUI [1])