Richter's syndrome | Chronic Lymphocytic Leukemia refractory | Prolymphocytic Leukemia refractory | fludarabine
Item
1. histologically or cytologically confirmed richter's transformation, fludarabine-refractory chronic lymphocytic leukemia or prolymphocytic leukemia.
boolean
C0349631 (UMLS CUI [1])
C0023434 (UMLS CUI [2,1])
C0205269 (UMLS CUI [2,2])
C0023486 (UMLS CUI [3,1])
C0205269 (UMLS CUI [3,2])
C0059985 (UMLS CUI [4])
Age
Item
2. patients must be 18 years of age or older.
boolean
C0001779 (UMLS CUI [1])
Zubrod Performance Status
Item
3. patients must have a performance status of 0-2 (zubrod scale).
boolean
C3714786 (UMLS CUI [1])
Renal function | Creatinine measurement, serum | Creatinine clearance measurement | Renal dysfunction Due to Organ Infiltration caused by Disease
Item
4. patients must have adequate renal function (serum creatinine below or equal to 2mg/dl or creatinine clearance greater than 30ml/min), unless renal dysfunction is considered due to organ infiltration by disease.
boolean
C0232804 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
C0373595 (UMLS CUI [3])
C3279454 (UMLS CUI [4,1])
C0678226 (UMLS CUI [4,2])
C0178784 (UMLS CUI [4,3])
C0332448 (UMLS CUI [4,4])
C0015127 (UMLS CUI [4,5])
C0012634 (UMLS CUI [4,6])
Liver function | Serum total bilirubin measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | leukemia | Hemolytic disorder Congenital
Item
5. patients must have adequate hepatic function (bilirubin less than or equal to 2.0 mg/dl; serum glutamic oxaloacetic transaminase (sgot) or serum glutamic pyruvic transaminase (sgpt) less than or equal to 3 times the upper limit of normal (uln) for the reference lab unless considered due to leukemia or congenital hemolytic disorder (for bilirubin).
boolean
C0232741 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0201899 (UMLS CUI [3])
C0201836 (UMLS CUI [4])
C0023418 (UMLS CUI [5])
C1263988 (UMLS CUI [6,1])
C1744681 (UMLS CUI [6,2])
Childbearing Potential Contraceptive methods | Postmenopausal state Duration Contraceptive methods | Gender Contraceptive methods
Item
6. female patients of childbearing potential (including those <1 year post-menopausal) and male patients must agree to use contraception.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0232970 (UMLS CUI [2,1])
C0449238 (UMLS CUI [2,2])
C0700589 (UMLS CUI [2,3])
C0079399 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
Informed Consent
Item
7. patients must sign an informed consent indicating that they are aware of the investigational nature of this study in keeping with the policies of the hospital.
boolean
C0021430 (UMLS CUI [1])
Platelet Count measurement | Disease Involvement with | Autoimmune Diseases
Item
8. patients must have platelet counts greater or equal to 20,000, unless due to disease involvement, or autoimmune disorders.
boolean
C0032181 (UMLS CUI [1])
C0012634 (UMLS CUI [2,1])
C1314939 (UMLS CUI [2,2])
C0004364 (UMLS CUI [3])
Life-threatening infection untreated | Life-threatening infection Uncontrolled
Item
1. untreated or uncontrolled life-threatening infection.
boolean
C1859430 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C1859430 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
intolerance to oxaliplatin | intolerance to fludarabine | intolerance to Cytarabine | intolerance to rituximab
Item
2. oxaliplatin, fludarabine, cytarabine or rituximab intolerance.
boolean
C1744706 (UMLS CUI [1,1])
C0069717 (UMLS CUI [1,2])
C1744706 (UMLS CUI [2,1])
C0059985 (UMLS CUI [2,2])
C1744706 (UMLS CUI [3,1])
C0010711 (UMLS CUI [3,2])
C1744706 (UMLS CUI [4,1])
C0393022 (UMLS CUI [4,2])
Pregnancy | Breast Feeding
Item
3. pregnancy or lactation.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Chemotherapy | Therapeutic radiology procedure
Item
4. chemotherapy and/or radiation therapy within 4 weeks.
boolean
C0392920 (UMLS CUI [1])
C1522449 (UMLS CUI [2])
medical condition Interferes with Protocol Compliance | medical condition Interferes with research results | Mental disorders Interfere with Protocol Compliance | Mental disorders Interfere with research results | Substance Use Disorders Interfere with Protocol Compliance | Substance Use Disorders Interfere with research results
Item
5. medical condition, including mental illness or substance abuse, deemed by the investigator to be likely to interfere with a patient's ability to sign informed consent, cooperate and participate in the study, or interfere with the interpretation of the results.
boolean
C3843040 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])
C3843040 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0683954 (UMLS CUI [2,3])
C0004936 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C0525058 (UMLS CUI [3,3])
C0004936 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C0683954 (UMLS CUI [4,3])
C0038586 (UMLS CUI [5,1])
C0521102 (UMLS CUI [5,2])
C0525058 (UMLS CUI [5,3])
C0038586 (UMLS CUI [6,1])
C0521102 (UMLS CUI [6,2])
C0683954 (UMLS CUI [6,3])