Philadelphia chromosome positive chronic myelogenous leukemia | Myeloid Leukemia, Chronic | BCR-ABL Fusion Gene Rearrangement | Cytogenetic Analysis Diploidy
Item
1. patients with ph(+) cml and/or cml with bcr-abl rearrangement and diploid cytogenetics not eligible for protocols of higher priority (e.g. id02-901, dm99-081, dm97-206, etc).
boolean
C0279543 (UMLS CUI [1])
C0023473 (UMLS CUI [2])
C1835417 (UMLS CUI [3,1])
C0017287 (UMLS CUI [3,2])
C0752095 (UMLS CUI [4,1])
C0012568 (UMLS CUI [4,2])
Disease Chronic phase Ordinal number | Accelerated phase | Blastic Phase | Chronic phase second
Item
2. the disease must be beyond first chronic phase according to ibmtr criteria (i.e. accelerated phase, blastic phase, second chronic phase) at the time of transplant.
boolean
C0012634 (UMLS CUI [1,1])
C0457343 (UMLS CUI [1,2])
C0439080 (UMLS CUI [1,3])
C0457345 (UMLS CUI [2])
C3899938 (UMLS CUI [3])
C0457343 (UMLS CUI [4,1])
C0205436 (UMLS CUI [4,2])
Philadelphia chromosome-positive acute lymphoblastic leukemia | Philadelphia chromosome positive Acute Myelocytic Leukemia
Item
3. patients with ph(+) acute lymphocytic (or myeloid) leukemia.
boolean
C1960397 (UMLS CUI [1])
C0023467 (UMLS CUI [2,1])
C0856536 (UMLS CUI [2,2])
Cytogenetic Analysis Diploidy | BCR-ABL Fusion Gene Rearrangement Evidence Molecular
Item
4. patients with diploid cytogenetics but molecular evidence of bcr-abl rearrangement are also eligible.
boolean
C0752095 (UMLS CUI [1,1])
C0012568 (UMLS CUI [1,2])
C1835417 (UMLS CUI [2,1])
C0017287 (UMLS CUI [2,2])
C3887511 (UMLS CUI [2,3])
C1521991 (UMLS CUI [2,4])
Age
Item
5. age >/= 16 years
boolean
C0001779 (UMLS CUI [1])
Absolute neutrophil count | Platelet Count measurement | Bone Marrow Transplantation
Item
6. unsupported anc at least 1500 and unsupported platelet count of at least 50k following bmt.
boolean
C0948762 (UMLS CUI [1])
C0032181 (UMLS CUI [2])
C0005961 (UMLS CUI [3])
Prior Chemotherapy Disease | Patients untreated
Item
7. patients may have received prior chemotherapy for their disease or be previously untreated.
boolean
C1514457 (UMLS CUI [1,1])
C0012634 (UMLS CUI [1,2])
C0030705 (UMLS CUI [2,1])
C0332155 (UMLS CUI [2,2])
Allogeneic bone marrow transplantation | Allogeneic Stem Cell Transplantation | Transplant type allogeneic | Tissue Donors Sibling HLA Matched | Living related donor Mismatch | Unrelated Donors | Preparative Regimen
Item
8. patients must have received an allogeneic bone marrow or stem cell transplant. allogeneic transplant types may include matched sibling donors, mismatched related donors, or unrelated donors. all preparative regimens acceptable.
boolean
C0149615 (UMLS CUI [1])
C2242529 (UMLS CUI [2])
C3840412 (UMLS CUI [3,1])
C1515895 (UMLS CUI [3,2])
C0040288 (UMLS CUI [4,1])
C0037047 (UMLS CUI [4,2])
C1548978 (UMLS CUI [4,3])
C3494891 (UMLS CUI [5,1])
C1881865 (UMLS CUI [5,2])
C3179133 (UMLS CUI [6])
C1882454 (UMLS CUI [7])
Informed Consent
Item
9. signed informed consent
boolean
C0021430 (UMLS CUI [1])
Zubrod Performance Status
Item
10. zubrod status </= 3
boolean
C3714786 (UMLS CUI [1])
Liver function | Serum total bilirubin measurement | Transaminases | Renal function | Creatinine measurement, serum
Item
11. adequate hepatic (bilirubin </= 3 mg/dl, transaminases < 4 x upper limit of normal) and renal function (serum creatinine </= 3 mg/dl )
boolean
C0232741 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0002594 (UMLS CUI [3])
C0232804 (UMLS CUI [4])
C0201976 (UMLS CUI [5])
Heart Diseases | New York Heart Association Classification
Item
1. grade iii/iv cardiac problems as defined by the nyhac
boolean
C0018799 (UMLS CUI [1])
C1275491 (UMLS CUI [2])
Hypersensitivity imatinib
Item
2. history of hypersensitivity to imatinib
boolean
C0020517 (UMLS CUI [1,1])
C0935989 (UMLS CUI [1,2])
Pregnancy | Breast Feeding
Item
3. pregnant and lactating women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
HIV Seropositivity
Item
4. hiv positive
boolean
C0019699 (UMLS CUI [1])