Age
Item
male or female, aged between 18 - 75 years of age inclusively.
boolean
C0001779 (UMLS CUI [1])
Hypertension, mild | Hypertension, moderate | Sitting diastolic blood pressure mean | Sitting systolic blood pressure mean | Pharmacotherapy Patient need for | Examination of blood pressure Quantity | Therapeutic procedure Patient need for | Diet education | Lifestyle education
Item
mild to moderate hypertension (msdbp >= 95 and >= 110 mmhg and / or mssbp >140mm hg) at visit 1, requiring pharmacological intervention. for newly diagnosed patients, hypertensive blood pressure values must be noted on at least two successive examinations prior to entry into the study. in addition, patients must require therapy despite having been following dietary & lifestyle advice for at least 3 months.
boolean
C3276943 (UMLS CUI [1])
C1969581 (UMLS CUI [2])
C1319894 (UMLS CUI [3,1])
C0444504 (UMLS CUI [3,2])
C1319893 (UMLS CUI [4,1])
C0444504 (UMLS CUI [4,2])
C0013216 (UMLS CUI [5,1])
C0686904 (UMLS CUI [5,2])
C0476712 (UMLS CUI [6,1])
C1265611 (UMLS CUI [6,2])
C0087111 (UMLS CUI [7,1])
C0686904 (UMLS CUI [7,2])
C0204932 (UMLS CUI [8])
C0730543 (UMLS CUI [9])
Informed Consent
Item
written informed consent to participate in the study, prior to any study procedures.
boolean
C0021430 (UMLS CUI [1])
Able to communicate | Protocol Compliance
Item
ability to communicate and comply with all study requirements
boolean
C2364293 (UMLS CUI [1])
C0525058 (UMLS CUI [2])
Uncontrolled hypertension | Sitting diastolic blood pressure | Sitting systolic blood pressure
Item
o uncontrolled hypertension defined as seated blood pressure of either systolic bp >180 mmhg and/or diastolic bp >110mmhg.
boolean
C1868885 (UMLS CUI [1])
C1319894 (UMLS CUI [2])
C1319893 (UMLS CUI [3])
LABORATORY ABNORMALITIES Clinical Significance Interfere with Investigational New Drug Safety | LABORATORY ABNORMALITIES Clinical Significance Interfere with Investigational New Drug Efficacy
Item
clinically significant laboratory abnormalities that may interfere with the assessment of safety and/or efficacy of the study drug
boolean
C1853129 (UMLS CUI [1,1])
C2826293 (UMLS CUI [1,2])
C0521102 (UMLS CUI [1,3])
C0013230 (UMLS CUI [1,4])
C0036043 (UMLS CUI [1,5])
C1853129 (UMLS CUI [2,1])
C2826293 (UMLS CUI [2,2])
C0521102 (UMLS CUI [2,3])
C0013230 (UMLS CUI [2,4])
C1280519 (UMLS CUI [2,5])
medical condition Severe Study Subject Participation Status Unsuccessful
Item
patients with severe medical condition(s) that in the view of the investigator may prohibit participation in the study
boolean
C3843040 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C2348568 (UMLS CUI [1,3])
C1272705 (UMLS CUI [1,4])
Renal Artery Stenosis
Item
renal artery stenosis
boolean
C0035067 (UMLS CUI [1])
Diabetes Mellitus
Item
diabetes mellitus
boolean
C0011849 (UMLS CUI [1])
Condition Due to Abnormal platelets | Condition Causing Abnormal platelets | Condition Due to abnormal clotting | Condition Causing abnormal clotting | Hemophilia | von Willebrand Disease
Item
any condition resulting from or leading to platelet or clotting abnormalities (eg. hemophilia, von willebrand's disease).
boolean
C0348080 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C0151854 (UMLS CUI [1,3])
C0348080 (UMLS CUI [2,1])
C0678227 (UMLS CUI [2,2])
C0151854 (UMLS CUI [2,3])
C0348080 (UMLS CUI [3,1])
C0678226 (UMLS CUI [3,2])
C0424562 (UMLS CUI [3,3])
C0348080 (UMLS CUI [4,1])
C0678227 (UMLS CUI [4,2])
C0424562 (UMLS CUI [4,3])
C0684275 (UMLS CUI [5])
C0042974 (UMLS CUI [6])
Event Vascular | Surgical and medical procedure Vascular | Myocardial Infarction | Percutaneous Transluminal Coronary Angioplasty | Coronary Artery Bypass Surgery
Item
history of a vascular event or intervention (e.g. mi, ptca or cabg) within 6 months preceding the study.
boolean
C0441471 (UMLS CUI [1,1])
C1801960 (UMLS CUI [1,2])
C1948041 (UMLS CUI [2,1])
C1801960 (UMLS CUI [2,2])
C0027051 (UMLS CUI [3])
C2936173 (UMLS CUI [4])
C0010055 (UMLS CUI [5])
Angina Pectoris Clinical Significance | Left Ventricular Hypertrophy | Transient Ischemic Attack | Cerebrovascular accident | Intermittent Claudication | Deep Vein Thrombosis | Pulmonary Embolism | Peripheral Vascular Diseases
Item
history of clinically significant angina, lvh, transient ischemic attack, stroke, intermittent claudication, deep vein thrombosis (dvt), pulmonary embolism or peripheral vascular disease.
boolean
C0002962 (UMLS CUI [1,1])
C2826293 (UMLS CUI [1,2])
C0149721 (UMLS CUI [2])
C0007787 (UMLS CUI [3])
C0038454 (UMLS CUI [4])
C0021775 (UMLS CUI [5])
C0149871 (UMLS CUI [6])
C0034065 (UMLS CUI [7])
C0085096 (UMLS CUI [8])
ATRIAL FIBRILLATION UNCONTROLLED Requirement Platelet Aggregation Inhibitors | ATRIAL FIBRILLATION UNCONTROLLED Requirement Therapeutic procedure Against Vitamin K | Condition Requirement Platelet Aggregation Inhibitors | Condition Requirement Therapeutic procedure Against Vitamin K
Item
uncontrolled atrial fibrillation (>100 b.p.m. at rest) or other conditions which may require anti-aggregant or anti-vitamin k therapies.
boolean
C0741284 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0032177 (UMLS CUI [1,3])
C0741284 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0087111 (UMLS CUI [2,3])
C0521124 (UMLS CUI [2,4])
C0042878 (UMLS CUI [2,5])
C0348080 (UMLS CUI [3,1])
C1514873 (UMLS CUI [3,2])
C0032177 (UMLS CUI [3,3])
C0348080 (UMLS CUI [4,1])
C1514873 (UMLS CUI [4,2])
C0087111 (UMLS CUI [4,3])
C0521124 (UMLS CUI [4,4])
C0042878 (UMLS CUI [4,5])
Congestive heart failure Evidence Clinical
Item
clinical evidence of congestive heart failure.
boolean
C0018802 (UMLS CUI [1,1])
C3887511 (UMLS CUI [1,2])
C0205210 (UMLS CUI [1,3])
Second degree atrioventricular block Evidence | Complete atrioventricular block Evidence | Sick Sinus Syndrome Evidence
Item
evidence of second or third degree heart block or sick sinus syndrome.
boolean
C0264906 (UMLS CUI [1,1])
C3887511 (UMLS CUI [1,2])
C0151517 (UMLS CUI [2,1])
C3887511 (UMLS CUI [2,2])
C0037052 (UMLS CUI [3,1])
C3887511 (UMLS CUI [3,2])