Age
Item
men and women ages 18 and older;
boolean
C0001779 (UMLS CUI [1])
Informed Consent
Item
willing to provide written informed consent;
boolean
C0021430 (UMLS CUI [1])
Uncontrolled hypertension | Diastolic blood pressure | Antihypertensive therapy | Antihypertensive Agent | Combined Modality Therapy
Item
must have uncontrolled hypertension defined as: currently untreated with a diastolic blood pressure greater than 110 mmhg or currently receiving antihypertensive monotherapy with a diastolic blood pressure greater than 100 mmhg. monotherapy is defined as treatment with one antihypertensive medication for at least four weeks; fixed combination therapy does not represent monotherapy;
boolean
C1868885 (UMLS CUI [1])
C0428883 (UMLS CUI [2])
C0585941 (UMLS CUI [3])
C0003364 (UMLS CUI [4])
C0009429 (UMLS CUI [5])
Antihypertensive Agents Discontinue Willing
Item
must be willing to discontinue antihypertensive medication, if applicable;
boolean
C0003364 (UMLS CUI [1,1])
C1444662 (UMLS CUI [1,2])
C0600109 (UMLS CUI [1,3])
Childbearing Potential Contraceptive methods | Low risk pregnancy
Item
women of childbearing potential (wocbp) must be using an adequate method of contraception to avoid pregnancy throughout the study and for up to one week after the study in such a manner that the risk of pregnancy is minimized.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0404841 (UMLS CUI [2])
Childbearing Potential Serum pregnancy test negative | Childbearing Potential Urine pregnancy test negative
Item
wocbp must have a negative serum or urine pregnancy test within 72 hours prior to the start of study medication.
boolean
C3831118 (UMLS CUI [1,1])
C0430061 (UMLS CUI [1,2])
C3831118 (UMLS CUI [2,1])
C0430057 (UMLS CUI [2,2])
Pregnancy | Breast Feeding
Item
women who are pregnant or breastfeeding;
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Secondary hypertension
Item
known or suspected secondary hypertension;
boolean
C0155616 (UMLS CUI [1])
Hypertensive emergency | Cerebrovascular accident
Item
hypertension emergencies or stroke within the past 12 months;
boolean
C0745136 (UMLS CUI [1])
C0038454 (UMLS CUI [2])
Myocardial Infarction | Angina Pectoris | Bypass Surgery
Item
heart attack, angina or bypass surgery within the past 6 months;
boolean
C0027051 (UMLS CUI [1])
C0002962 (UMLS CUI [2])
C1536078 (UMLS CUI [3])
Kidney Disease Significant
Item
significant kidney disease;
boolean
C0022658 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
Liver disease Significant
Item
significant liver disease;
boolean
C0023895 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
Lupus Erythematosus, Systemic
Item
systemic lupus erythematosus;
boolean
C0024141 (UMLS CUI [1])
Gastrointestinal Disease Interferes with drug absorption | Gastrointestinal Surgical Procedure Interferes with drug absorption
Item
gastrointestinal disease or surgery that may interfere with drug absorption;
boolean
C0017178 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0678745 (UMLS CUI [1,3])
C0524722 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0678745 (UMLS CUI [2,3])
Malignant Neoplasms | Squamous cell carcinoma Localized | Basal cell carcinoma Localized
Item
cancer during the past five years excluding localized squamous cell or basal cell carcinoma of the skin;
boolean
C0006826 (UMLS CUI [1])
C0007137 (UMLS CUI [2,1])
C0392752 (UMLS CUI [2,2])
C0007117 (UMLS CUI [3,1])
C0392752 (UMLS CUI [3,2])
Pregnancy | Breast Feeding
Item
currently pregnant or lactating;
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Mental disorder Study Protocol Comprehension Unable | Cerebral disorder Study Protocol Comprehension Unable
Item
mental condition (psychiatric or organic cerebral disease) rendering the subject unable to understand the nature, scope, and possible consequences of the study;
boolean
C0004936 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])
C0162340 (UMLS CUI [1,3])
C1299582 (UMLS CUI [1,4])
C0234387 (UMLS CUI [2,1])
C2348563 (UMLS CUI [2,2])
C0162340 (UMLS CUI [2,3])
C1299582 (UMLS CUI [2,4])
Substance Use Disorders
Item
drug or alcohol abuse within the last five years;
boolean
C0038586 (UMLS CUI [1])
Hypersensitivity irbesartan | Hypersensitivity Diuretics
Item
known allergy to irbesartan or diuretics.
boolean
C0020517 (UMLS CUI [1,1])
C0288171 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0012798 (UMLS CUI [2,2])