Liver cell carcinoma non-resectable | Metastatic hepatocellular carcinoma
Item
unresectable or metastatic hepatocellular carcinoma
boolean
C1112459 (UMLS CUI [1])
C0744869 (UMLS CUI [2])
Measurable Disease
Item
measurable tumors
boolean
C1513041 (UMLS CUI [1])
Liver function | Serum total bilirubin measurement | Aspartate aminotransferase measurement
Item
adequate hepatic function: total bilirubin < 3.0mg/dl; ast < 7x uln
boolean
C0232741 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0201899 (UMLS CUI [3])
Bone Marrow function | Absolute neutrophil count | Platelet Count measurement
Item
adequate bone marrow function: anc > 1,000/mm3; platelets > 75,000/mm3
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0948762 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
INR | Anticoagulation Therapy
Item
inr < 1.5 for those who are not on anticoagulation
boolean
C0525032 (UMLS CUI [1])
C0003281 (UMLS CUI [2])
Prior Chemotherapy Quantity Liver carcinoma
Item
up to two prior chemotherapy regimens for hepatocellular carcinoma
boolean
C1514457 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C2239176 (UMLS CUI [1,3])
Age
Item
18 years of age or older
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
ecog performance status of 0-1
boolean
C1520224 (UMLS CUI [1])
Life Expectancy
Item
life expectancy of > 12 weeks
boolean
C0023671 (UMLS CUI [1])
CNS metastases apparent Clinical | Meningeal Carcinomatosis
Item
clinically apparent central nervous system metastases or carcinomatous meningitis
boolean
C0686377 (UMLS CUI [1,1])
C0750489 (UMLS CUI [1,2])
C0205210 (UMLS CUI [1,3])
C0220654 (UMLS CUI [2])
Illness Serious Uncontrolled | Mental disorders
Item
uncontrolled serious medical or psychiatric illness
boolean
C0221423 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])
C0004936 (UMLS CUI [2])
Pregnancy | Breast Feeding
Item
pregnant or lactating women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Study Subject Participation Status | Investigational New Drugs
Item
current or recent (within 4 weeks of first study infusion) participation in experimental study drug
boolean
C2348568 (UMLS CUI [1])
C0013230 (UMLS CUI [2])
Uncontrolled hypertension
Item
uncontrolled hypertension
boolean
C1868885 (UMLS CUI [1])
Proteinuria Significant
Item
significant proteinuria
boolean
C0033687 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
Non-healed wound Serious | Ulcer | Fracture
Item
serious, non-healing wound, ulcer, or bone fracture
boolean
C0750433 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0041582 (UMLS CUI [2])
C0016658 (UMLS CUI [3])
Bleeding tendency Evidence of | Blood Coagulation Disorders Evidence of
Item
evidence of bleeding diathesis or coagulopathy
boolean
C1458140 (UMLS CUI [1,1])
C0332120 (UMLS CUI [1,2])
C0005779 (UMLS CUI [2,1])
C0332120 (UMLS CUI [2,2])