Squamous cell carcinoma of skin expressing moderately or highly the egfr
Item
histological scc of the skin expressing (ihc) moderately or highly the egfr (++ and +++, on a semi-quantitative scale).
boolean
C0553723 (UMLS CUI [1])
C0034802 (UMLS CUI [2,1])
C0021044 (UMLS CUI [2,2])
locally advanced or metastatic scc of the skin not suitable for local surgery with documented progression
Item
locally advanced or metastatic scc of the skin not suitable for local surgery with documented progression.
boolean
C0553723 (UMLS CUI [1,1])
C0677984 (UMLS CUI [1,2])
C2063963 (UMLS CUI [2])
C1096417 (UMLS CUI [3,1])
C1548788 (UMLS CUI [3,2])
C0242656 (UMLS CUI [4])
measurable lesion
Item
presence of at least one measurable target lesion by recist criteria.
boolean
C1513041 (UMLS CUI [1])
lesion accessible to biopsy
Item
at least one lesion accessible to biopsies.
boolean
C0856310 (UMLS CUI [1])
ECOG
Item
ecog performance status < 2.
boolean
C1520224 (UMLS CUI [1])
life expectancy
Item
life expectancy > 3 months.
boolean
C0023671 (UMLS CUI [1])
Age
Item
age > 18 years.
boolean
C0001779 (UMLS CUI [1])
hematological, hepatic and renal function
Item
normal hematological (neutrophils > 1.5x109 cells/l, platelets > 100x109 cells/l), hepatic (bilirubin < 1.5 times the upper limit of the normal range (uln); alkaline phosphatase and transaminases < 5 x unl in case of hepatic metastases or < 2.5 x unl in absence of hepatic metastases) and renal (serum creatinine < 150 micromol/l) functions.
boolean
C0200633 (UMLS CUI [1])
C0032181 (UMLS CUI [2])
C0201913 (UMLS CUI [3])
C0201850 (UMLS CUI [4])
C0201836 (UMLS CUI [5])
C0201899 (UMLS CUI [6])
C0201976 (UMLS CUI [7])
informed consent
Item
written informed consent.
boolean
C0021430 (UMLS CUI [1])
Other malignancy
Item
in case of second tumor,excepted carcinoma of the cervix and adequately treated basal or squamous cell skin carcinoma, the possibility for including a patient may be discussed with the principal investigator.
boolean
C0006826 (UMLS CUI [1])
chemotherapy
Item
prior chemotherapy
boolean
C0392920 (UMLS CUI [1])
radiotherapy
Item
prior radiotherapy < 1 month.
boolean
C1522449 (UMLS CUI [1])
Agent targeting egfr
Item
prior therapy with agent targeting egfr
boolean
C1443775 (UMLS CUI [1])
C4055105 (UMLS CUI [2])
systemic diseases or active uncontrolled infection
Item
unstable systemic diseases or active uncontrolled infections.
boolean
C0442893 (UMLS CUI [1])
C0009450 (UMLS CUI [2])
Contraception
Item
patients (male and female) not using effective contraception if of reproductive potential.
boolean
C0700589 (UMLS CUI [1])
pregnant or lactating, pregnancy test
Item
females pregnant or lactating. women of child bearing potential must have a negative serum or urine pregnancy test prior to start each cycle of treatment.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0032976 (UMLS CUI [3])