Major Depressive Disorder
Item
meets diagnostic criteria for major depressive disorder
boolean
C1269683 (UMLS CUI [1])
Single major depressive episode
Item
meets criteria for current major depressive episode
boolean
C0024517 (UMLS CUI [1])
Montgomery-Asberg Depression Rating Scale Questionnaire
Item
score of at least 18 on the montgomery-asberg depression rating scale (madrs) at the baseline visit
boolean
C4054475 (UMLS CUI [1])
Antidepressive Agents Dosage
Item
currently being treated with antidepressant monotherapy at an adequate dose for 6 weeks or willing to enter open lead-in treatment
boolean
C0003289 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
Contraceptive methods Agree
Item
agrees to use an effective form of contraception throughout the study
boolean
C0700589 (UMLS CUI [1,1])
C3641827 (UMLS CUI [1,2])
Pregnancy
Item
pregnant
boolean
C0032961 (UMLS CUI [1])
At risk for suicide | Homicide At risk
Item
at risk for suicide or homicide
boolean
C0563664 (UMLS CUI [1])
C0019872 (UMLS CUI [2,1])
C1444641 (UMLS CUI [2,2])
Illness Unstable | Cardiovascular Diseases | Liver diseases | Kidney Diseases | Respiration Disorders | Endocrine System Diseases | nervous system disorder | Epilepsy Uncontrolled
Item
unstable medical illness (e.g., cardiovascular, liver, kidney, respiratory, endocrine, or neurologic disease, including uncontrolled seizure disorder)
boolean
C0221423 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
C0007222 (UMLS CUI [2])
C0023895 (UMLS CUI [3])
C0022658 (UMLS CUI [4])
C0035204 (UMLS CUI [5])
C0014130 (UMLS CUI [6])
C0027765 (UMLS CUI [7])
C0014544 (UMLS CUI [8,1])
C0205318 (UMLS CUI [8,2])
Substance Use Disorders
Item
history of a substance use disorder within 6 months of study enrollment
boolean
C0038586 (UMLS CUI [1])
depression psychotic feature
Item
history of or current psychotic features
boolean
C0743076 (UMLS CUI [1])
Antipsychotic Agents | Antipsychotic Agents Atypical
Item
currently being treated with typical or atypical antipsychotic medications
boolean
C0040615 (UMLS CUI [1])
C0040615 (UMLS CUI [2,1])
C0205182 (UMLS CUI [2,2])
Pharmaceutical Preparations Decreasing Significant Pramipexole Clearance | Cimetidine | Ranitidine | Dilacor | Verapamil | Quinine | Triamterene
Item
currently being treated with a medication known to significantly decrease pramipexole clearance (e.g., cimetidine, ranitidine, diltazem, verapamil, quinine or triamterene)
boolean
C0013227 (UMLS CUI [1,1])
C0442797 (UMLS CUI [1,2])
C0750502 (UMLS CUI [1,3])
C0074710 (UMLS CUI [1,4])
C1382187 (UMLS CUI [1,5])
C0008783 (UMLS CUI [2])
C0034665 (UMLS CUI [3])
C2587066 (UMLS CUI [4])
C0042523 (UMLS CUI [5])
C0034417 (UMLS CUI [6])
C0040869 (UMLS CUI [7])
Hypothyroidism untreated Evidence of
Item
clinical or laboratory evidence of untreated hypothyroidism
boolean
C2749407 (UMLS CUI [1,1])
C0332120 (UMLS CUI [1,2])
Pramipexole Course Length
Item
history of a 2-week or longer course of pramipexole
boolean
C0074710 (UMLS CUI [1,1])
C0750729 (UMLS CUI [1,2])
C1444754 (UMLS CUI [1,3])
intolerance to Pramipexole Dosage
Item
intolerance of pramipexole at any dose
boolean
C1744706 (UMLS CUI [1,1])
C0074710 (UMLS CUI [1,2])
C0178602 (UMLS CUI [1,3])
Psychotropic Drugs Investigational
Item
any investigational psychotropic drug use within the last three months
boolean
C0033978 (UMLS CUI [1,1])
C1517586 (UMLS CUI [1,2])
Antidepressive Agents Resistance Level
Item
level 3 or greater antidepressant resistance as assessed by the athf
boolean
C0003289 (UMLS CUI [1,1])
C0013203 (UMLS CUI [1,2])
C0441889 (UMLS CUI [1,3])
Self-harm Episodes Quantity
Item
three or more episodes of self-harm in the year prior to study enrollment
boolean
C0424366 (UMLS CUI [1,1])
C0332189 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
Adherence to treatment Poor | Missed appointment Frequently
Item
documented history of poor treatment adherence or frequently missed appointments
boolean
C0516958 (UMLS CUI [1,1])
C2700379 (UMLS CUI [1,2])
C3854235 (UMLS CUI [2,1])
C0332183 (UMLS CUI [2,2])
Parkinson Disease
Item
parkinson's disease
boolean
C0030567 (UMLS CUI [1])