Age
Item
age 12 months to 16 years inclusive
boolean
C0001779 (UMLS CUI [1])
parental consent
Item
signed parental/guardian informed consent and assent from the subject
boolean
C0600634 (UMLS CUI [1])
current treatment for hypertension, systolic blood pressure
Item
current treatment for hypertension, or, if not currently treated for hypertension, systolic blood pressure (sbp) greater than or equal to 95th percentile for gender and height-for-age, or, if not currently treated for hypertension, systolic blood pressure or diastolic blood pressure greater than or equal to 90th percentile for gender and height-for-age and diabetic or having a family history of hypertension
boolean
C0020538 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
C0871470 (UMLS CUI [2])
eGFR
Item
glomerular filtration rate (gfr) greater than or equal to 30 ml/min/1.73 m2, estimated using the schwartz equation
boolean
C3811844 (UMLS CUI [1])
Contraception
Item
sexually active females of child-bearing potential must be practicing an acceptable method of birth control
boolean
C0700589 (UMLS CUI [1])
Serum pregnancy test
Item
negative serum beta-human chorionic gonadotropin at screening and at admission (female of child-bearing potential only)
boolean
C0430060 (UMLS CUI [1])
cardiac, gastrointestinal, hematologic, hepatic or hepatobiliary, neurologic, or pulmonary (except asthma) disorder
Item
clinically significant cardiac, gastrointestinal, hematologic, hepatic or hepatobiliary, neurologic, or pulmonary (except asthma) disorder
boolean
C0232164 (UMLS CUI [1])
C0017178 (UMLS CUI [2])
C0018939 (UMLS CUI [3])
C0232741 (UMLS CUI [4])
C0267792 (UMLS CUI [5])
C0027765 (UMLS CUI [6])
C0024115 (UMLS CUI [7])
hypertension associated with stroke, seizures, encephalopathy, or other significant neurologic findings
Item
history of severe or symptomatic hypertension associated with stroke, seizures, encephalopathy, or other significant neurologic findings within 1 year prior to screening
boolean
C0020538 (UMLS CUI [1,1])
C0332281 (UMLS CUI [1,2])
C0038454 (UMLS CUI [1,3])
C0020538 (UMLS CUI [2,1])
C0332281 (UMLS CUI [2,2])
C0036572 (UMLS CUI [2,3])
C0020538 (UMLS CUI [3,1])
C0332281 (UMLS CUI [3,2])
C0085584 (UMLS CUI [3,3])
C0020538 (UMLS CUI [4,1])
C0332281 (UMLS CUI [4,2])
C0422837 (UMLS CUI [4,3])
Antihypertensive medications
Item
current treatment with more than 2 antihypertensive medications
boolean
C0003364 (UMLS CUI [1])
secondary hypertension from uncorrected coarctation of the aorta or renal artery stenosis
Item
secondary hypertension from uncorrected coarctation of the aorta, bilateral renal artery stenosis, or unilateral renal artery stenosis in a single kidney
boolean
C0155616 (UMLS CUI [1,1])
C0003492 (UMLS CUI [1,2])
C0155616 (UMLS CUI [2,1])
C0035067 (UMLS CUI [2,2])
Serum albumin
Item
serum albumin < 2.5 g/dl
boolean
C0523465 (UMLS CUI [1])
major organ or bone marrow transplantation
Item
major organ or bone marrow transplantation except for prior kidney transplantation of at least 6 months and with stable renal function meeting the inclusion criteria
boolean
C0029216 (UMLS CUI [1])
C0005961 (UMLS CUI [2])