Non-Hodgkin Lymphoma Involvement with Brain | X-Ray Computed Tomography | Magnetic Resonance Imaging | Cerebrospinal Fluid Cytology Positive Lymphoma | Lymphocyte | Surface Antigens
Item
all patients must have non-hodgkin's lymphoma involving the brain, as demonstrated by ct or mri and histologic confirmation by one of the following: a positive csf cytology for lymphoma or a monoclonal lymphocyte population as defined by cell surface markers.
boolean
C0024305 (UMLS CUI [1,1])
C1314939 (UMLS CUI [1,2])
C0006104 (UMLS CUI [1,3])
C0040405 (UMLS CUI [2])
C0024485 (UMLS CUI [3])
C0007806 (UMLS CUI [4,1])
C1305671 (UMLS CUI [4,2])
C1446409 (UMLS CUI [4,3])
C0024299 (UMLS CUI [4,4])
C0024264 (UMLS CUI [5])
C0003339 (UMLS CUI [6])
Lymphoma, Non-Hodgkin | Biopsy of vitreous | Biopsy Uvea | Biopsy brain
Item
a biopsy of the vitreous or uvea demonstrating non-hodgkin's lymphoma. brain biopsy.
boolean
C0024305 (UMLS CUI [1])
C0395547 (UMLS CUI [2])
C0005558 (UMLS CUI [3,1])
C0042160 (UMLS CUI [3,2])
C0740294 (UMLS CUI [4])
HIV-1 Negative
Item
patients must be hiv-1 negative.
boolean
C2363741 (UMLS CUI [1,1])
C0205160 (UMLS CUI [1,2])
Left ventricular ejection fraction
Item
patient must have left ventricular ejection fraction ≥ 50%.
boolean
C0428772 (UMLS CUI [1])
Lymphoma Systemic Evidence | Chest CT | CT of abdomen | Computerized Tomography (CT Scan) of Pelvis
Item
patients must have no evidence of systemic lymphoma. this must be demonstrated by a ct scan of the chest, abdomen and pelvis prior to registration.
boolean
C0024299 (UMLS CUI [1,1])
C0205373 (UMLS CUI [1,2])
C0332120 (UMLS CUI [1,3])
C0202823 (UMLS CUI [2])
C0412620 (UMLS CUI [3])
C2456699 (UMLS CUI [4])
Bone Marrow function | White Blood Cell Count | Blood Platelets | Liver function | Serum total bilirubin measurement | Renal function | Creatinine measurement, serum | Creatinine clearance measurement
Item
patients must have adequate bone marrow function (defined as peripheral leucocyte count >3000 cells/mm3 and platelet count > 100,000 cells/mm3), liver function (bilirubin < 2.0 mg%), and adequate renal function (serum creatinine < 1.5 mg/dl or creatinine clearance > 50cc/min/1.73m2).
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0023508 (UMLS CUI [2])
C0005821 (UMLS CUI [3])
C0232741 (UMLS CUI [4])
C1278039 (UMLS CUI [5])
C0232804 (UMLS CUI [6])
C0201976 (UMLS CUI [7])
C0373595 (UMLS CUI [8])
Females & males of reproductive potential Contraceptive methods
Item
men and women of reproductive potential must agree to use an acceptable method of birth control during treatment and for six months after completion of treatment.
boolean
C4034483 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Age
Item
patients must be between 18 and 72 years-old.
boolean
C0001779 (UMLS CUI [1])
Informed consent
Item
patients must sign an informed consent.
boolean
C0021430 (UMLS CUI [1])
Cranial Irradiation
Item
prior cranial irradiation
boolean
C0079172 (UMLS CUI [1])
Primary malignant neoplasm | Basal cell carcinoma | Carcinoma in situ of uterine cervix
Item
other active primary malignancy with the exception of basal cell carcinoma of the skin and cervical carcinoma in situ.
boolean
C1306459 (UMLS CUI [1])
C0007117 (UMLS CUI [2])
C0851140 (UMLS CUI [3])
Immunologic Deficiency Syndrome Pre-existing | Renal graft Recipient
Item
pre-existing immunodeficiency such as renal transplant recipient.
boolean
C0021051 (UMLS CUI [1,1])
C2347662 (UMLS CUI [1,2])
C0022671 (UMLS CUI [2,1])
C1709854 (UMLS CUI [2,2])
Prior Chemotherapy Primary central nervous system lymphoma
Item
prior treatment with chemotherapy for cns lymphoma.
boolean
C1514457 (UMLS CUI [1,1])
C0280803 (UMLS CUI [1,2])