Periodontal Diseases | Comorbidity Major | Cardiovascular Diseases | Medical Problem Major
Item
1. the study seeks to enroll patients with periodontal disease and no other major co-morbidities including cardiovascular disease or other major medical problems.
boolean
C0031090 (UMLS CUI [1])
C0009488 (UMLS CUI [2,1])
C0205164 (UMLS CUI [2,2])
C0007222 (UMLS CUI [3])
C1254481 (UMLS CUI [4,1])
C0205164 (UMLS CUI [4,2])
Cigarette smoker
Item
2. in this intervention study, cigarette smokers will be permitted as justified below and randomized in stratified fashion to ensure equal numbers in the two treatment groups.
boolean
C0337667 (UMLS CUI [1])
Cardiovascular Diseases | Coronary heart disease | Cerebrovascular Disorders | Peripheral Vascular Diseases | Heart valve disease | Congestive heart failure
Item
1. known cardiovascular disease including coronary heart disease, cerebral vascular disease, peripheral vascular disease, valvular heart disease, and congestive heart failure.
boolean
C0007222 (UMLS CUI [1])
C0010068 (UMLS CUI [2])
C0007820 (UMLS CUI [3])
C0085096 (UMLS CUI [4])
C0018824 (UMLS CUI [5])
C0018802 (UMLS CUI [6])
risk factors Coronary Major | Diabetes Mellitus Treatment required for | Hypertensive disease Treatment required for | Hypercholesterolemia Treatment required for
Item
2. major coronary risk factors including diabetes mellitus, hypertension, hypercholesterolemia requiring treatment according to the atp-iii guidelines.
boolean
C0035648 (UMLS CUI [1,1])
C1522318 (UMLS CUI [1,2])
C0205164 (UMLS CUI [1,3])
C0011849 (UMLS CUI [2,1])
C0332121 (UMLS CUI [2,2])
C0020538 (UMLS CUI [3,1])
C0332121 (UMLS CUI [3,2])
C0020443 (UMLS CUI [4,1])
C0332121 (UMLS CUI [4,2])
Illness Major | Malignant Neoplasms | Liver diseases | Kidney Diseases | Lung diseases | Chronic infectious disease | HIV Infections | Hepatitis C | rheumatologic disorder | Hematological Disease | Condition Requirement Hospitalization | Condition Requirement Therapeutic procedure chronic
Item
3. other major illness including cancer, liver disease, renal disease, pulmonary disease, chronic infectious disease (including hiv and hepatitis c infection), rheumatological disease, hematological disease, or any condition requiring hospitalization or chronic medical therapy.
boolean
C0221423 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
C0006826 (UMLS CUI [2])
C0023895 (UMLS CUI [3])
C0022658 (UMLS CUI [4])
C0024115 (UMLS CUI [5])
C0151317 (UMLS CUI [6])
C0019693 (UMLS CUI [7])
C0019196 (UMLS CUI [8])
C0009326 (UMLS CUI [9])
C0018939 (UMLS CUI [10])
C0348080 (UMLS CUI [11,1])
C1514873 (UMLS CUI [11,2])
C0019993 (UMLS CUI [11,3])
C0348080 (UMLS CUI [12,1])
C1514873 (UMLS CUI [12,2])
C0087111 (UMLS CUI [12,3])
C0205191 (UMLS CUI [12,4])
Antibiotics
Item
4. use of antibiotics within three months.
boolean
C0003232 (UMLS CUI [1])
Contraceptive Agents | Hormone replacement therapy
Item
5. use of oral contraceptives or hormone replacement therapy.
boolean
C0009871 (UMLS CUI [1])
C0282402 (UMLS CUI [2])
Mental disorders Major Requirement Therapeutic procedure | Mental disorders Major Compliance behavior Limited
Item
6. major psychiatric illness requiring treatment or that might interfere with the ability to understand and cooperate with the protocol.
boolean
C0004936 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
C1514873 (UMLS CUI [1,3])
C0087111 (UMLS CUI [1,4])
C0004936 (UMLS CUI [2,1])
C0205164 (UMLS CUI [2,2])
C1321605 (UMLS CUI [2,3])
C0439801 (UMLS CUI [2,4])
Substance Use Disorders Continuous
Item
7. ongoing drug or alcohol abuse.
boolean
C0038586 (UMLS CUI [1,1])
C0549178 (UMLS CUI [1,2])
Viagra | Risk Hypotension Marked | Nitroglycerin Administration
Item
8. use of sildenafil (viagra) within 7 days because of the risk of marked hypotension with nitroglycerin administration.
boolean
C0663448 (UMLS CUI [1])
C0035647 (UMLS CUI [2,1])
C0020649 (UMLS CUI [2,2])
C1706089 (UMLS CUI [2,3])
C0017887 (UMLS CUI [3,1])
C1533734 (UMLS CUI [3,2])
Migraine Disorders | Disease Exacerbation Due to Nitroglycerin
Item
9. history of migraine headaches that might be exacerbated by nitroglycerin.
boolean
C0149931 (UMLS CUI [1])
C0235874 (UMLS CUI [2,1])
C0678226 (UMLS CUI [2,2])
C0017887 (UMLS CUI [2,3])
Therapeutic procedure Anticholesteremic Agents | Angiotensin-Converting Enzyme Inhibitors | Risk factor for cardiovascular disease
Item
10. use of cholesterol lowering therapy, angiotensin converting enzyme inhibitors (subjects should not be taking these drugs because they will have no history of cardiovascular disease risk factors).
boolean
C0087111 (UMLS CUI [1,1])
C0003277 (UMLS CUI [1,2])
C0003015 (UMLS CUI [2])
C0847284 (UMLS CUI [3])
Antioxidant vitamin requirement Recommended Dietary Allowances | Ascorbic Acid | Vitamin E
Item
11. antioxidant vitamins (vitamin c or vitamin e) in doses exceeding the recommended dietary allowances (rda), (60 mg/day and 30 iu/day, respectively).
boolean
C0556073 (UMLS CUI [1,1])
C0524787 (UMLS CUI [1,2])
C0003968 (UMLS CUI [2])
C0042874 (UMLS CUI [3])
Pregnancy | Serum Beta-HCG Test
Item
12. pregnancy, as diagnosed by serum beta-hcg.
boolean
C0032961 (UMLS CUI [1])
C1255526 (UMLS CUI [2])