Adenoid Cystic Carcinoma | Overexpression KIT | Immunohistochemistry | Recurrent disease | X-Ray Computed Tomography | Magnetic Resonance Imaging
Item
histologically or cytologically proven adenoid cystic carcinoma overexpressing kit (by immunohistochemistry) with recurrent disease documented by computed tomography (ct) scan or magnetic resonance imaging (mri).
boolean
C0010606 (UMLS CUI [1])
C1514559 (UMLS CUI [2,1])
C1416655 (UMLS CUI [2,2])
C0021044 (UMLS CUI [3])
C0277556 (UMLS CUI [4])
C0040405 (UMLS CUI [5])
C0024485 (UMLS CUI [6])
Target Lesion Measurable | Contrast Enhancing Lesion | Diameter size | X-Ray Computed Tomography | Magnetic Resonance Imaging
Item
presence of at least one dimensionally measurable target lesion (contrast enhancing lesion with the largest diameter >= 2 cm, based on ct or mri scan done within 4 weeks before the start of treatment).
boolean
C2986546 (UMLS CUI [1,1])
C1513040 (UMLS CUI [1,2])
C3830314 (UMLS CUI [2])
C1301886 (UMLS CUI [3,1])
C0456389 (UMLS CUI [3,2])
C0040405 (UMLS CUI [4])
C0024485 (UMLS CUI [5])
Able to swallow oral medication
Item
patients able to swallow an oral compound.
boolean
C2712086 (UMLS CUI [1,1])
C0175795 (UMLS CUI [1,2])
WHO performance status scale
Item
world health organization (who) performance status < 2.
boolean
C1298650 (UMLS CUI [1])
Life Expectancy
Item
life expectancy of >= 3 months.
boolean
C0023671 (UMLS CUI [1])
Age
Item
aged >= 18 years.
boolean
C0001779 (UMLS CUI [1])
Hematologic function | Absolute neutrophil count | Platelet Count measurement | Liver function | Serum total bilirubin measurement | Alkaline phosphatase measurement | Transaminases | Renal function | Creatinine measurement, serum
Item
normal hematological (neutrophils >= 1.5 x 10^9 cells/l, platelets >= 100 x 10^9 cells/l), hepatic (bilirubin < 1.5 times the upper limit of the normal range; alkaline phosphatase and transaminases <= 2.5 x the upper limit of the normal range) and renal (serum creatinine <= 150 mmol/l) functions.
boolean
C0221130 (UMLS CUI [1])
C0948762 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
C0232741 (UMLS CUI [4])
C1278039 (UMLS CUI [5])
C0201850 (UMLS CUI [6])
C0002594 (UMLS CUI [7])
C0232804 (UMLS CUI [8])
C0201976 (UMLS CUI [9])
Informed consent
Item
written informed consent.
boolean
C0021430 (UMLS CUI [1])
Cardiac function test abnormal | Ischaemic heart disease | 12 lead ECG Abnormal
Item
abnormal cardiac function with history of ischaemic heart disease in the past 6 months and/or abnormal 12 lead electrocardiogram (ecg).
boolean
C0438177 (UMLS CUI [1])
C1869045 (UMLS CUI [2])
C0430456 (UMLS CUI [3,1])
C0205161 (UMLS CUI [3,2])
Malignant Neoplasms Site | Cervix carcinoma Conization | Basal cell carcinoma Treated Adequate | Squamous cell carcinoma of skin Treated Adequate
Item
previous or current malignancies at other sites with the exception of cone biopsied carcinoma of the cervix and adequately treated basal or squamous cell skin carcinoma.
boolean
C0006826 (UMLS CUI [1,1])
C1515974 (UMLS CUI [1,2])
C0302592 (UMLS CUI [2,1])
C0195324 (UMLS CUI [2,2])
C0007117 (UMLS CUI [3,1])
C1522326 (UMLS CUI [3,2])
C0205411 (UMLS CUI [3,3])
C0553723 (UMLS CUI [4,1])
C1522326 (UMLS CUI [4,2])
C0205411 (UMLS CUI [4,3])
Warfarin | Anticoagulants
Item
concomitant treatment with warfarin or any other anticoagulants.
boolean
C0043031 (UMLS CUI [1])
C0003280 (UMLS CUI [2])
Systemic disease Unstable | Communicable Disease Uncontrolled
Item
unstable systemic diseases or active uncontrolled infections.
boolean
C0442893 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
C0009450 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
Females & males of reproductive potential Contraceptive methods
Item
patients (male and female) not using effective contraception if of reproductive potential.
boolean
C4034483 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Pregnancy | Breast Feeding | Blood beta human chorionic gonadotropin positive
Item
females pregnant or lactating or positive beta human chorionic gonadotropin (bhcg) at baseline
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C1868907 (UMLS CUI [3])