ID.1
Item
general inclusion criteria:
boolean
subjects under 60 years are only male
Item
subjects under 60 years are only male.
boolean
C0001779 (UMLS CUI [1,1])
C0079399 (UMLS CUI [1,2])
subjects from 60 to 85 may be male or female
Item
subjects from 60 to 85 may be male or female
boolean
C0001779 (UMLS CUI [1,1])
C0079399 (UMLS CUI [1,2])
health insurance status
Item
subjects that have a health insurance
boolean
C2136534 (UMLS CUI [1])
caffeine abstinence
Item
subjects will be asked to refrain from caffein for at least 12 hours
boolean
C0006644 (UMLS CUI [1])
ID.6
Item
specific inclusion criteria for part 2:
boolean
ID.7
Item
subjects with
boolean
ID.8
Item
specific inclusion criteria for part 3:
boolean
alzheimers disease and MMS Score
Item
subjects with alzheimer diseased based on the dsm iv and nincds-adrda criteria. with a mms between 15 and 26 (included).
boolean
C0002395 (UMLS CUI [1,1])
C1532985 (UMLS CUI [1,2])
informed consent and accompagined by a person of confidence
Item
subjects capable of giving an informed consent and accompagined by a person of confidence
boolean
C0021430 (UMLS CUI [1])
ID.11
Item
specific inclusion criteria for part 4:
boolean
ADNFLE mutation
Item
subjects with adnfle with or without demonstrated mutation on the nicotinic receptors
boolean
C3696898 (UMLS CUI [1])
ID.13
Item
general exclusion criteria:
boolean
abnormal mri findings
Item
subjects with abnormal mri findings at visual inspection
boolean
C2830579 (UMLS CUI [1])
medical disorders, chronic cholinergic treatment
Item
subjects with a history of significant medical disordres, or requiering chronic treatment that interfere with the cholinergic system
boolean
C0012634 (UMLS CUI [1])
C0242893 (UMLS CUI [2])
C0242896 (UMLS CUI [3])
Blood test abnormal
Item
subjects with abnormal plasma biological analysis
boolean
C0854146 (UMLS CUI [1])
medical history of hypertension, cardiovascular disease and diabetes mellitus
Item
subjects with significant past and present history of hypertension, cardiovascular disease and diabetes mellitus
boolean
C0262926 (UMLS CUI [1,1])
C0020538 (UMLS CUI [1,2])
C0262926 (UMLS CUI [2,1])
C0007222 (UMLS CUI [2,2])
C0262926 (UMLS CUI [3,1])
C0011849 (UMLS CUI [3,2])
pacemakers, aneurysm clips, metallic prostheses, shrapnel fragments
Item
subjects who have pacemakers, aneurysm clips (metal clips) metallic prostheses (including heart valves and cochlear implants) or shrapnel fragments.
boolean
C0030163 (UMLS CUI [1])
C0179977 (UMLS CUI [2])
C0175649 (UMLS CUI [3])
subjects incapable of giving an informed consent
Item
subjects incapable of giving an informed consent
boolean
C0021430 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])
ID.20
Item
specific exclusion criteria for part 2:
boolean
smoking history
Item
subjects with a smoking history in the last five years
boolean
C1519384 (UMLS CUI [1])
ID.22
Item
specific exclusion criteria for part 3:
boolean
ID.23
Item
subjects with a smoking history in the last five years
boolean
ID.24
Item
specific exclusion criteria for part 4:
boolean
ID.25
Item
subjects with a smoking history in the last five years
boolean