Postmenopausal state | Breast Carcinoma
Item
postmenopausal women who have histologically-confirmed breast cancer with the following characteristics:
boolean
C0232970 (UMLS CUI [1])
C0678222 (UMLS CUI [2])
Estrogen receptor positive | progesterone receptor positive
Item
estrogen and/or progesterone receptor positive,
boolean
C0279754 (UMLS CUI [1])
C0279759 (UMLS CUI [2])
advanced disease Locally
Item
locally advanced disease
boolean
C0679246 (UMLS CUI [1,1])
C1517927 (UMLS CUI [1,2])
Neoplasm Metastasis Distant
Item
distant metastatic disease, stage 4
boolean
C0027627 (UMLS CUI [1,1])
C0443203 (UMLS CUI [1,2])
Therapeutic procedure Disease | Aromatase Inhibitors
Item
subjects eligible for single-agent treatment with aromatase inhibitors for current disease.
boolean
C0087111 (UMLS CUI [1,1])
C0012634 (UMLS CUI [1,2])
C0593802 (UMLS CUI [2])
Diphosphonates Intake
Item
subjects taking biophosphonates are allowed if they begin bisphosphonate therapy at least two weeks prior to randomization.
boolean
C0012544 (UMLS CUI [1,1])
C1512806 (UMLS CUI [1,2])
Measurable Disease | Mass in breast Diameter | Tumor margin status | Diagnostic Imaging | Tomography, Spiral Computed | Evaluable Disease | Bone Diseases
Item
measurable disease (masses with clearly defined margins on radiological images and at least one diameter >=20 mm[>=10 mm if spiral ct]) or evaluable disease (masses with margins not clearly defined on radiological images or with no diameter >= 20 mm). subjects with bone disease only are permitted if disease is evaluable.
boolean
C1513041 (UMLS CUI [1])
C0024103 (UMLS CUI [2,1])
C1301886 (UMLS CUI [2,2])
C1269830 (UMLS CUI [3])
C0011923 (UMLS CUI [4])
C0860888 (UMLS CUI [5])
C1516986 (UMLS CUI [6])
C0005940 (UMLS CUI [7])
ECOG performance status
Item
ecog performance status of 0 or 1.
boolean
C1520224 (UMLS CUI [1])
Bone Marrow Mature Neutrophils Sufficient
Item
sufficient bone marrow reserve.
boolean
C0005953 (UMLS CUI [1,1])
C1708947 (UMLS CUI [1,2])
C0205410 (UMLS CUI [1,3])
Liver function | Renal function | Normal Laboratory Test Result
Item
adequate hepatic and renal function: laboratory values within protocol requirements.
boolean
C0232741 (UMLS CUI [1])
C0232804 (UMLS CUI [2])
C0438214 (UMLS CUI [3])
Cytotoxic Chemotherapy advanced disease
Item
subjects who have received more than one regimen of cytotoxic chemotherapy for advanced disease.
boolean
C0677881 (UMLS CUI [1,1])
C0679246 (UMLS CUI [1,2])
Metastatic malignant neoplasm to brain | Disease Visceral Extensive | Hepatic Involvement Extensive | Malignant Neoplasm pulmonary Lymphangitic spread
Item
subjects with with clinically apparent brain metastases or extensive visceral disease, including extensive hepatic involvement or pulmonary lymphangitic spread of tumor.
boolean
C0220650 (UMLS CUI [1])
C0012634 (UMLS CUI [2,1])
C0442045 (UMLS CUI [2,2])
C0205231 (UMLS CUI [2,3])
C0441932 (UMLS CUI [3,1])
C0205231 (UMLS CUI [3,2])
C0006826 (UMLS CUI [4,1])
C0024109 (UMLS CUI [4,2])
C3697833 (UMLS CUI [4,3])
Farnesyl Transferase Inhibitors
Item
subjects with prior treatments with ftis.
boolean
C1517132 (UMLS CUI [1])
Hypersensitivity lonafarnib Pharmaceutical Excipient | Hypersensitivity Povidone | Hypersensitivity Poloxamer 188 | Hypersensitivity Croscarmellose Sodium | Hypersensitivity Silicon Dioxide | Hypersensitivity Magnesium stearate
Item
subjects with a known or suspected hypersensitivity to any excipients in the lonafarnib formulation (providone, poloxamer 188, croscarmellose sodium, silicon dioxide, and magnesium stearate).
boolean
C0020517 (UMLS CUI [1,1])
C1257385 (UMLS CUI [1,2])
C0015237 (UMLS CUI [1,3])
C0020517 (UMLS CUI [2,1])
C0032856 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3,1])
C0600611 (UMLS CUI [3,2])
C0020517 (UMLS CUI [4,1])
C0010353 (UMLS CUI [4,2])
C0020517 (UMLS CUI [5,1])
C0037098 (UMLS CUI [5,2])
C0020517 (UMLS CUI [6,1])
C0126791 (UMLS CUI [6,2])