Diabetes Mellitus, Non-Insulin-Dependent Diabetic on diet only | Oral hypoglycemic Absent | Insulin Absent
Item
type 2 diabetes (world health organisation (who) criteria), managed by diet alone (i.e. no oral hypoglycaemic drugs or insulin)
boolean
C0011860 (UMLS CUI [1,1])
C0421246 (UMLS CUI [1,2])
C0359086 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0021641 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Body mass index
Item
body mass index (bmi) 20 - 40 kg/m2
boolean
C1305855 (UMLS CUI [1])
Age
Item
age 18 - 70 years
boolean
C0001779 (UMLS CUI [1])
Gender | Postmenopausal state | control Menstrual cycle Effect Gut Hormone secretion
Item
males and post-menopausal females (to control for the effect of the menstrual cycle on gut hormone secretion)
boolean
C0079399 (UMLS CUI [1])
C0232970 (UMLS CUI [2])
C0243148 (UMLS CUI [3,1])
C0025329 (UMLS CUI [3,2])
C1280500 (UMLS CUI [3,3])
C0699819 (UMLS CUI [3,4])
C0312431 (UMLS CUI [3,5])
Hemoglobin A1c measurement
Item
glycated haemoglobin a1c (hba1c) ≥ 6.0% and ≤ 7.9%
boolean
C0474680 (UMLS CUI [1])
Hemoglobin measurement | Gender | Ferritin measurement
Item
haemoglobin above the lower limit of the normal range (i.e. >135g/l for men and 115g/l for women), and ferritin above the lower limit of normal (i.e. >10mcg/l)
boolean
C0518015 (UMLS CUI [1])
C0079399 (UMLS CUI [2])
C0373607 (UMLS CUI [3])
Pharmaceutical Preparations Affecting function gastrointestinal motor | Pharmaceutical Preparations Affecting Body Weight | Pharmaceutical Preparations Affecting appetite
Item
use of any medication that may influence gastrointestinal motor function, body weight or appetite
boolean
C0013227 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0031843 (UMLS CUI [1,3])
C0521362 (UMLS CUI [1,4])
C1513492 (UMLS CUI [1,5])
C0013227 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C0005910 (UMLS CUI [2,3])
C0013227 (UMLS CUI [3,1])
C0392760 (UMLS CUI [3,2])
C0003618 (UMLS CUI [3,3])
Drug abuse | Alcohol consumption Unit per Gram per Day | Cigarette smoker Number of cigarettes per day
Item
evidence of drug abuse, consumption of more than 20 g alcohol or 10 cigarettes on a daily basis
boolean
C0013146 (UMLS CUI [1])
C0001948 (UMLS CUI [2,1])
C2349072 (UMLS CUI [2,2])
C0337667 (UMLS CUI [3,1])
C3694146 (UMLS CUI [3,2])
Gastrointestinal Diseases | Symptoms Significant Upper Gastrointestinal Tract | Symptoms Significant Lower Gastrointestinal Tract | Pancreatitis | Gastrointestinal Surgical Procedure | Appendectomy Uncomplicated | Cholecystectomy Uncomplicated
Item
history of gastrointestinal disease, including significant upper or lower gastrointestinal symptoms, pancreatitis, or previous gastrointestinal surgery (other than uncomplicated appendicectomy or cholecystectomy)
boolean
C0017178 (UMLS CUI [1])
C1457887 (UMLS CUI [2,1])
C0750502 (UMLS CUI [2,2])
C3203348 (UMLS CUI [2,3])
C1457887 (UMLS CUI [3,1])
C0750502 (UMLS CUI [3,2])
C0226875 (UMLS CUI [3,3])
C0030305 (UMLS CUI [4])
C0524722 (UMLS CUI [5])
C0003611 (UMLS CUI [6,1])
C0443334 (UMLS CUI [6,2])
C0008320 (UMLS CUI [7,1])
C0443334 (UMLS CUI [7,2])
Illness Significant | Epilepsy | Cardiovascular Diseases | Respiration Disorders
Item
other significant illness, including epilepsy, cardiovascular or respiratory disease
boolean
C0221423 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
C0014544 (UMLS CUI [2])
C0007222 (UMLS CUI [3])
C0035204 (UMLS CUI [4])
Autonomic nerve injury
Item
autonomic nerve damage (as assessed by standardised cardiovascular reflex tests [36])
boolean
C0560614 (UMLS CUI [1])
Renal Insufficiency | Liver Dysfunction | Creatinine clearance measurement | Liver function tests abnormal
Item
impaired renal or liver function (as assessed by calculated creatinine clearance < 90 ml/min or abnormal liver function tests (> 2 times upper limit of normal range))
boolean
C1565489 (UMLS CUI [1])
C0086565 (UMLS CUI [2])
C0373595 (UMLS CUI [3])
C0151766 (UMLS CUI [4])
Hypersensitivity vildagliptin
Item
allergy to vildagliptin or any other 'gliptin'
boolean
C0020517 (UMLS CUI [1,1])
C1570906 (UMLS CUI [1,2])
Blood Donation
Item
donation of blood within the previous 3 months
boolean
C0005794 (UMLS CUI [1])
Study Subject Participation Status
Item
participation in any other research studies within the previous 3 months
boolean
C2348568 (UMLS CUI [1])
Premenopause
Item
females who are pre-menopausal
boolean
C0206158 (UMLS CUI [1])
Informed Consent Unable
Item
inability to give informed consent
boolean
C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
Vegetarian
Item
vegetarians
boolean
C0042441 (UMLS CUI [1])