Age
Item
1. age ≥18 years.
boolean
C0001779 (UMLS CUI [1])
Diabetes Mellitus
Item
2. diabetes, as per american diabetes association criteria.
boolean
C0011849 (UMLS CUI [1])
Polyneuropathy | Nerve conduction study | Motor nerve Median | Motor nerve Ulnar | Motor nerve tibial | Motor nerve Peroneal | Demyelination
Item
3. clinical evidence of polyneuropathy and ncs shows 2 separate motor nerves (median, ulnar, tibial, or peroneal) which meet criteria for demyelination, defined as follows:
boolean
C0152025 (UMLS CUI [1])
C0200125 (UMLS CUI [2])
C0501384 (UMLS CUI [3,1])
C2939193 (UMLS CUI [3,2])
C0501384 (UMLS CUI [4,1])
C0442044 (UMLS CUI [4,2])
C0501384 (UMLS CUI [5,1])
C0040184 (UMLS CUI [5,2])
C0501384 (UMLS CUI [6,1])
C0442035 (UMLS CUI [6,2])
C0011304 (UMLS CUI [7])
Conduction velocity | Latency Motor nerve Distal | Latency F wave
Item
1. conduction velocity <90% lower limit of normal (lln), distal latency >110% upper limit of normal (uln), or minimal f-wave latency >110% uln
boolean
C0234084 (UMLS CUI [1])
C0242465 (UMLS CUI [2,1])
C0501384 (UMLS CUI [2,2])
C0205108 (UMLS CUI [2,3])
C0242465 (UMLS CUI [3,1])
C0429081 (UMLS CUI [3,2])
Change Due to Median Neuropathy Wrist | Change Due to Ulnar Neuropathy Elbow | Change Due to peroneal neuropathy at the fibular head
Item
2. the changes are not exclusively due to median neuropathy at the wrist, ulnar neuropathy at the elbow, or peroneal neuropathy at the fibular head.
boolean
C0392747 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C0751922 (UMLS CUI [1,3])
C0043262 (UMLS CUI [1,4])
C0392747 (UMLS CUI [2,1])
C0678226 (UMLS CUI [2,2])
C0154743 (UMLS CUI [2,3])
C0013769 (UMLS CUI [2,4])
C0392747 (UMLS CUI [3,1])
C0678226 (UMLS CUI [3,2])
C3662126 (UMLS CUI [3,3])
Peripheral demyelinating neuropathy Suspicion
Item
4. clinical suspicion of possible demyelinating polyneuropathy (cidp).
boolean
C0270922 (UMLS CUI [1,1])
C0242114 (UMLS CUI [1,2])
Pregnancy | Childbearing Potential | Contraceptive methods Not used
Item
1. pregnant patients, or those of childbearing potential not using contraception.
boolean
C0032961 (UMLS CUI [1])
C3831118 (UMLS CUI [2])
C0700589 (UMLS CUI [3,1])
C0445107 (UMLS CUI [3,2])
Age
Item
2. patients <18 years of age.
boolean
C0001779 (UMLS CUI [1])
Peripheral Neuropathy | Etiology aspects | Inherited neuropathies | Charcot-Marie-Tooth Disease | Neuropathy Due Vitamin B Deficiency | Neuropathy Due to Excess | Uremic neuropathy | Neuropathy Secondary to Monoclonal Gammapathies | Neuropathy Due to Malignant Neoplasms | Neuropathy Due to Chemotherapy | Exposure to toxin | Alcoholic Neuropathy
Item
3. presence of an alternative etiology of peripheral neuropathy, such as: hereditary neuropathies (charcot marie-tooth disease); b-vitamin deficiency- or excess-related neuropathy; uremic neuropathy; neuropathy secondary to monoclonal gammopathy; history of cancer- or chemotherapy-related neuropathy; other toxin exposures; and alcoholic neuropathy.
boolean
C0031117 (UMLS CUI [1])
C0015127 (UMLS CUI [2])
C0598589 (UMLS CUI [3])
C0007959 (UMLS CUI [4])
C0442874 (UMLS CUI [5,1])
C0678226 (UMLS CUI [5,2])
C0042850 (UMLS CUI [5,3])
C0442874 (UMLS CUI [6,1])
C0678226 (UMLS CUI [6,2])
C1979886 (UMLS CUI [6,3])
C0268708 (UMLS CUI [7])
C0442874 (UMLS CUI [8,1])
C0175668 (UMLS CUI [8,2])
C1136085 (UMLS CUI [8,3])
C0442874 (UMLS CUI [9,1])
C0678226 (UMLS CUI [9,2])
C0006826 (UMLS CUI [9,3])
C0442874 (UMLS CUI [10,1])
C0678226 (UMLS CUI [10,2])
C0392920 (UMLS CUI [10,3])
C0040537 (UMLS CUI [11])
C0085677 (UMLS CUI [12])
Medical contraindication Immunoglobulins, Intravenous | Recurrent thrombophlebitis | Immunoglobulin A deficiency | Hypersensitivity Immunoglobulins, Intravenous | Kidney Failure | Recurrent deep vein thrombosis | Pulmonary Embolism | Cerebrovascular accident | Myocardial Infarction
Item
4. contraindication to ivig, including: history of recurrent thrombosis, immunoglobulin a deficiency, or severe hypersensitivity reaction to ivig in past, renal failure, recurrent deep venous thrombosis, pulmonary embolus, stroke, or myocardial infarction.
boolean
C1301624 (UMLS CUI [1,1])
C0085297 (UMLS CUI [1,2])
C3550150 (UMLS CUI [2])
C0162538 (UMLS CUI [3])
C0020517 (UMLS CUI [4,1])
C0085297 (UMLS CUI [4,2])
C0035078 (UMLS CUI [5])
C1735901 (UMLS CUI [6])
C0034065 (UMLS CUI [7])
C0038454 (UMLS CUI [8])
C0027051 (UMLS CUI [9])
medical condition Compliance behavior Limited | medical condition Immunoglobulins, Intravenous Unable | Heart failure | Uncontrolled hypertension | Anemia, severe
Item
5. presence of serious or unstable medical condition, which may preclude study completion or lead to inability to tolerate ivig. this may include active heart failure, uncontrolled hypertension, or severe anemia, among other conditions.
boolean
C1699700 (UMLS CUI [1,1])
C1321605 (UMLS CUI [1,2])
C0439801 (UMLS CUI [1,3])
C1699700 (UMLS CUI [2,1])
C0085297 (UMLS CUI [2,2])
C1299582 (UMLS CUI [2,3])
C0018801 (UMLS CUI [3])
C1868885 (UMLS CUI [4])
C0238644 (UMLS CUI [5])
nervous system disorder Interferes with Evaluation
Item
6. presence of concomitant neurological illness, which may confound evaluation.
boolean
C0027765 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0220825 (UMLS CUI [1,3])
Informed Consent failed
Item
7. fails or unable to provide informed consent.
boolean
C0021430 (UMLS CUI [1,1])
C0231175 (UMLS CUI [1,2])