Informed consent
Item
1. voluntary signature of the irb approved informed consent
boolean
C0021430 (UMLS CUI [1])
Osteoarthritis, Knee Unilateral | Age
Item
2. unilateral osteoarthritic male or female ages 35-85
boolean
C0409959 (UMLS CUI [1,1])
C0205092 (UMLS CUI [1,2])
C0001779 (UMLS CUI [2])
Knee Affected | Pain | Swelling | functional disability | Degenerative polyarthritis Knee joint
Item
3. pain, swelling, and/or functional disability in the affected knee consistent with osteoarthritis in one knee joint
boolean
C0022742 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0030193 (UMLS CUI [2])
C0038999 (UMLS CUI [3])
C0872173 (UMLS CUI [4])
C0029408 (UMLS CUI [5,1])
C0022745 (UMLS CUI [5,2])
Physical Examination Consistent with Degenerative polyarthritis Knee joint
Item
4. physical examination consistent with osteoarthritis in one knee joint
boolean
C0031809 (UMLS CUI [1,1])
C0332290 (UMLS CUI [1,2])
C0029408 (UMLS CUI [1,3])
C0022745 (UMLS CUI [1,4])
Knee Affected | Range of motion Restricted | Knee flexion | extension of knee
Item
5. restricted range of motion of the affected knee (<135 degrees in flexion and/or >0 degrees of extension)
boolean
C0022742 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C2607871 (UMLS CUI [2,1])
C0443288 (UMLS CUI [2,2])
C0240114 (UMLS CUI [3])
C2237139 (UMLS CUI [4])
Osteoarthritis, Knee | Magnetic Resonance Imaging | Kellgren-Lawrence score
Item
6. kellgren-lawrence grade 2 or greater knee osteoarthritis with diagnostic mr imaging of the affected knee showing osteoarthritis
boolean
C0409959 (UMLS CUI [1])
C0024485 (UMLS CUI [2])
C3177117 (UMLS CUI [3])
Osteoarthritis, Knee | grade of knee effusion Limited | Synovial Fluid Visible | Knee Ultrasonography
Item
7. limited knee effusion in osteoarthritic knee (i.e. not more than 20 ml of visible joint fluid on ultrasound examination of the knee.)
boolean
C0409959 (UMLS CUI [1])
C2109494 (UMLS CUI [2,1])
C0439801 (UMLS CUI [2,2])
C0039097 (UMLS CUI [3,1])
C0205379 (UMLS CUI [3,2])
C0022742 (UMLS CUI [4,1])
C0041618 (UMLS CUI [4,2])
Knee Unaffected | Range of motion Normal
Item
8. normal range of motion of the unaffected knee
boolean
C0022742 (UMLS CUI [1,1])
C2986417 (UMLS CUI [1,2])
C2607871 (UMLS CUI [2,1])
C0205307 (UMLS CUI [2,2])
Knee Unaffected | Pain Absent | Swelling Absent | functional disability Absent
Item
9. no sign of pain, swelling, and/or functional disability of the unaffected knee
boolean
C0022742 (UMLS CUI [1,1])
C2986417 (UMLS CUI [1,2])
C0030193 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0038999 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C0872173 (UMLS CUI [4,1])
C0332197 (UMLS CUI [4,2])
Knee Unaffected | acute knee injury Absent
Item
10. no history of acute injury in the unaffected knee
boolean
C0022742 (UMLS CUI [1,1])
C2986417 (UMLS CUI [1,2])
C0850518 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
Independent | Ambulatory | Compliance behavior Study Protocol
Item
11. is independent, ambulatory, and can comply with all post-operative evaluations and visits
boolean
C1299583 (UMLS CUI [1])
C0439841 (UMLS CUI [2])
C1321605 (UMLS CUI [3,1])
C2348563 (UMLS CUI [3,2])
Injection Knee
Item
1. knee injections of any type within 6 months prior to the study.
boolean
C1533685 (UMLS CUI [1,1])
C0022742 (UMLS CUI [1,2])
inflammatory joint disease | Arthropathy Autoimmune | Lower Extremity Pathological aspects | Rheumatoid Arthritis | Lupus Erythematosus, Systemic | Arthritis, Psoriatic | Polymyalgia | Polymyositis | Gout | Pseudogout
Item
2. inflammatory or auto-immune based joint diseases or other lower extremity pathology (e.g., rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, polymyalgia, polymyositis, gout pseudogout)
boolean
C0683381 (UMLS CUI [1])
C0022408 (UMLS CUI [2,1])
C0443146 (UMLS CUI [2,2])
C0023216 (UMLS CUI [3,1])
C0205469 (UMLS CUI [3,2])
C0003873 (UMLS CUI [4])
C0024141 (UMLS CUI [5])
C0003872 (UMLS CUI [6])
C0521516 (UMLS CUI [7])
C0085655 (UMLS CUI [8])
C0018099 (UMLS CUI [9])
C0033802 (UMLS CUI [10])
Myopathy Quinolone induced | Tendinopathy Quinolone induced | Myopathy statin induced | Tendinopathy statin induced
Item
3. quinolone or statin induced myopathy/tendinopathy
boolean
C0026848 (UMLS CUI [1,1])
C0034428 (UMLS CUI [1,2])
C0007994 (UMLS CUI [1,3])
C1568272 (UMLS CUI [2,1])
C0034428 (UMLS CUI [2,2])
C0007994 (UMLS CUI [2,3])
C0026848 (UMLS CUI [3,1])
C0360714 (UMLS CUI [3,2])
C0007994 (UMLS CUI [3,3])
C1568272 (UMLS CUI [4,1])
C0360714 (UMLS CUI [4,2])
C0007994 (UMLS CUI [4,3])
Disorder of lumbar spine Symptomatic | Radicular pain
Item
4. symptomatic lumbar spine pathology (e.g. radicular pain)
boolean
C1290147 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
C0278147 (UMLS CUI [2])
Knee Nerve Cutaneous | Neurogenic Inflammation Severe | thigh Nerve Cutaneous | Neurogenic Inflammation Severe | Complex Regional Pain Syndromes | Central Nervous System Sensitization | Allodynia
Item
5. severe neurogenic inflammation of the cutaneous nerves about the knee or thigh (i.e. evidence of complex regional pain syndrome or central sensitization with allodynia present on exam).
boolean
C0022742 (UMLS CUI [1,1])
C0027740 (UMLS CUI [1,2])
C0221912 (UMLS CUI [1,3])
C0600467 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C1281586 (UMLS CUI [3,1])
C0027740 (UMLS CUI [3,2])
C0221912 (UMLS CUI [3,3])
C0600467 (UMLS CUI [4,1])
C0205082 (UMLS CUI [4,2])
C0458219 (UMLS CUI [5])
C2938905 (UMLS CUI [6])
C0458247 (UMLS CUI [7])
Medical contraindication Magnetic Resonance Imaging
Item
6. contraindications for mri
boolean
C1301624 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])
Malignant Neoplasms Test Positive | Therapeutic procedure Malignant Neoplasms | Suspected malignancy | Therapeutic radiology procedure Malignant Neoplasms | Chemotherapy Malignant Neoplasms | Injection site
Item
7. tested positive or has been treated for a malignancy in the past five years or is suspected of having a malignancy or is currently undergoing radiation or chemotherapy treatment for a malignancy anywhere in the body, whether adjacent to or distant from the proposed injection site
boolean
C0006826 (UMLS CUI [1,1])
C0392366 (UMLS CUI [1,2])
C1446409 (UMLS CUI [1,3])
C0087111 (UMLS CUI [2,1])
C0006826 (UMLS CUI [2,2])
C0581833 (UMLS CUI [3])
C1522449 (UMLS CUI [4,1])
C0006826 (UMLS CUI [4,2])
C0392920 (UMLS CUI [5,1])
C0006826 (UMLS CUI [5,2])
C2700396 (UMLS CUI [6])
Condition Worker Compensation
Item
8. condition represents a worker's compensation case
boolean
C0348080 (UMLS CUI [1,1])
C0043233 (UMLS CUI [1,2])
Litigation Health Related | Involvement with
Item
9. currently involved in a health-related litigation procedure
boolean
C0079706 (UMLS CUI [1,1])
C0018684 (UMLS CUI [1,2])
C0439849 (UMLS CUI [1,3])
C1314939 (UMLS CUI [2])
Pregnancy
Item
10. is pregnant
boolean
C0032961 (UMLS CUI [1])
Blood Coagulation Disorders
Item
11. bleeding disorders
boolean
C0005779 (UMLS CUI [1])
Anticoagulants | Immunosuppressive Agents
Item
12. currently taking anticoagulant or immunosuppressive medication
boolean
C0003280 (UMLS CUI [1])
C0021081 (UMLS CUI [2])
Hypersensitivity Investigational New Drugs | intolerance to Investigational New Drugs
Item
13. allergy or intolerance to study medication
boolean
C0020517 (UMLS CUI [1,1])
C0013230 (UMLS CUI [1,2])
C1744706 (UMLS CUI [2,1])
C0013230 (UMLS CUI [2,2])
Opioids chronic | Use of
Item
14. use of chronic opioid
boolean
C0242402 (UMLS CUI [1,1])
C0205191 (UMLS CUI [1,2])
C1524063 (UMLS CUI [2])
Drug abuse
Item
15. documented history of drug abuse within six months of treatment
boolean
C0013146 (UMLS CUI [1])
Condition Study Subject Participation Status Limited
Item
18) any other condition, that in the opinion of the investigator, that would preclude the patient from enrollment
boolean
C0348080 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])
C0439801 (UMLS CUI [1,3])