age
Item
men and women between the ages of 30 and 55 years
boolean
C0001779 (UMLS CUI [1])
type 2 diabetes
Item
persons with type 2 diabetes taking only certain oral medications (
boolean
C0011860 (UMLS CUI [1])
pre-menopausal women
Item
pre-menopausal women
boolean
C0043210 (UMLS CUI [1,1])
C0279752 (UMLS CUI [1,2])
hba1c level
Item
persons with type 2 diabetes who have a total hba1c level <9%
boolean
C0019018 (UMLS CUI [1])
BMI
Item
persons with a bmi between 25-35.
boolean
C1305855 (UMLS CUI [1])
smoking
Item
current smokers or anyone who has smoked within the last year
boolean
C1519384 (UMLS CUI [1])
distal symmetrical neuropathy
Item
persons who have clinically evident distal symmetrical neuropathy
boolean
C0587045 (UMLS CUI [1,1])
C0205108 (UMLS CUI [1,2])
abnormal lipid levels
Item
abnormal lipid levels (total cholesterol >200, ldl-cholesterol level >130, or triglyceride level >250).
boolean
C1445957 (UMLS CUI [1])
C0202117 (UMLS CUI [2])
C0041004 (UMLS CUI [3])
regional wall motion abnormalities
Item
persons with regional wall motion abnormalities, left ventricular wall thickness >1.1 cm , or decreased contractility.
boolean
C2024793 (UMLS CUI [1])
evidence of ischemic heart disease
Item
persons will also be excluded if they have evidence of ischemic heart disease by history or abnormal resting or exercise electrocardiogram (ecg).
boolean
C0151744 (UMLS CUI [1])
C1304755 (UMLS CUI [2])
blood pressure
Item
presence of systolic blood pressure >140 mmhg at rest or >250 mmhg with exercise or diastolic pressure >90 mmhg at rest or >105 mmhg with exercise will be grounds for exclusion.
boolean
C0005823 (UMLS CUI [1])
peripheral arterial disease
Item
subjects will be excluded who have peripheral arterial disease.
boolean
C1704436 (UMLS CUI [1])
autonomic insufficiency
Item
persons with autonomic insufficiency, assessed by measuring variation in rr intervals with cycled breathing and by presence of a >20 mm fall in upright blood pressure without a change in heart rate, will be excluded.
boolean
C1400371 (UMLS CUI [1])
renal disease
Item
subjects with proteinuria (urine protein >200 mg/dl) or a creatinine > 2 mg/dl, suggestive of renal disease will be excluded.
boolean
C0033687 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
C0022658 (UMLS CUI [3])
immediate family history of type 2 diabetes mellitus
Item
controls will not be accepted with an immediate family history of type 2 diabetes mellitus
boolean
C1313937 (UMLS CUI [1])