Diagnosis Histology | Measurable Disease | Multiple Myeloma | Disease Progression
Item
histologically confirmed diagnosis, measurable disease and evidence of disease progression of multiple myeloma, as described below.
boolean
C0011900 (UMLS CUI [1,1])
C0344441 (UMLS CUI [1,2])
C1513041 (UMLS CUI [2])
C0026764 (UMLS CUI [3])
C0242656 (UMLS CUI [4])
Multiple Myeloma Symptomatic | Measurable Disease
Item
symptomatic multiple myeloma, based on imwg guidelines. patients must have measurable disease as defined by at least one of the following:
boolean
C0026764 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
C1513041 (UMLS CUI [2])
M Protein | Serum protein electrophoresis | IgA myeloma | Immunoglobulin A measurement Quantitative
Item
1. serum m-protein ≥ 5 g/l by serum electrophoresis (spep) or for immunoglobulin a (iga) myeloma, by quantitative iga; or
boolean
C0700271 (UMLS CUI [1])
C0201720 (UMLS CUI [2])
C0563305 (UMLS CUI [3])
C0202083 (UMLS CUI [4,1])
C0392762 (UMLS CUI [4,2])
Excretion measurement M Protein In Urine
Item
2. urinary m-protein excretion at least 200 mg/24 hours; or
boolean
C0201808 (UMLS CUI [1,1])
C0700271 (UMLS CUI [1,2])
C0042037 (UMLS CUI [1,3])
Serum Free Immunoglobulin Light Chain Involvement | Serum Immunoglobulin Free Light Chain Ratio Abnormal
Item
3. involved serum free light chains ≥ 100 mg/l, provided that free light chain ratio is abnormal
boolean
C2827352 (UMLS CUI [1,1])
C1314939 (UMLS CUI [1,2])
C2826181 (UMLS CUI [2])
Serum protein electrophoresis unreliable | M Protein Measurement | Immunoglobulin level Quantitative | Nephelometry | Turbidimetry
Item
4. if serum protein electrophoresis is felt to be unreliable for routine m-protein measurement, then quantitative immunoglobulin levels by nephelometry or turbidometry are acceptable.
boolean
C0201720 (UMLS CUI [1,1])
C0749770 (UMLS CUI [1,2])
C0700271 (UMLS CUI [2,1])
C0242485 (UMLS CUI [2,2])
C0428536 (UMLS CUI [3,1])
C0392762 (UMLS CUI [3,2])
C0027692 (UMLS CUI [4])
C0041394 (UMLS CUI [5])
Resolution Toxic effect Due to Pharmaceutical Preparations
Item
resolution of prior drug-related toxicities to ≤ grade 1.
boolean
C1514893 (UMLS CUI [1,1])
C0600688 (UMLS CUI [1,2])
C0678226 (UMLS CUI [1,3])
C0013227 (UMLS CUI [1,4])
Multiple Myeloma Relapsed | Refractory multiple myeloma
Item
relapsed and/or refractory multiple myeloma.
boolean
C0026764 (UMLS CUI [1,1])
C0205336 (UMLS CUI [1,2])
C0278620 (UMLS CUI [2])
Smoldering myeloma
Item
smoldering mm.
boolean
C1531608 (UMLS CUI [1])
Multiple Myeloma | Gene Expression | M Protein | Free Immunoglobulin Light Chain | Non-secretory myeloma | Immunoglobulin level Quantitative
Item
multiple myeloma that does not express m-protein or free light chain(flc) (i.e., non-secretory mm is excluded), and quantitative immunoglobulin levels cannot be used instead.
boolean
C0026764 (UMLS CUI [1])
C0017262 (UMLS CUI [2])
C0700271 (UMLS CUI [3])
C0806492 (UMLS CUI [4])
C0456845 (UMLS CUI [5])
C0428536 (UMLS CUI [6,1])
C0392762 (UMLS CUI [6,2])
Primary amyloidosis of light chain type Systemic | Amyloid
Item
documented systemic amyloid light chain amyloidosis.
boolean
C0342606 (UMLS CUI [1,1])
C0205373 (UMLS CUI [1,2])
C0002716 (UMLS CUI [2])
Multiple Myeloma Involvement with Central Nervous System
Item
active mm involving the central nervous system (cns).
boolean
C0026764 (UMLS CUI [1,1])
C1314939 (UMLS CUI [1,2])
C3714787 (UMLS CUI [1,3])
Leukemia, Plasma Cell
Item
plasma cell leukemia.
boolean
C0023484 (UMLS CUI [1])
Protocol Treatment Arm selinexor Dexamethasone bortezomib | Neuropathy | Neuropathy, Painful
Item
on the selinexor + dexamethasone + bortezomib (sdb) arm only: prior history of neuropathy grade > 2, or grade 2 neuropathy with pain at baseline (within 14 days prior to cycle 1 day 1).
boolean
C1522541 (UMLS CUI [1,1])
C3852671 (UMLS CUI [1,2])
C0011777 (UMLS CUI [1,3])
C1176309 (UMLS CUI [1,4])
C0442874 (UMLS CUI [2])
C1850383 (UMLS CUI [3])