Age
Item
men and women ≥ 18 years of age.
boolean
C0001779 (UMLS CUI [1])
Multiple Myeloma | Recurrent disease | Refractory Prior Therapy | Disease Progression
Item
a confirmed diagnosis of mm, which has relapsed after, or been refractory to ≥ 1 prior therapy for mm, and is progressing at the time of study entry.
boolean
C0026764 (UMLS CUI [1])
C0277556 (UMLS CUI [2])
C0205269 (UMLS CUI [3,1])
C1514463 (UMLS CUI [3,2])
C0242656 (UMLS CUI [4])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status of ≤ 2.
boolean
C1520224 (UMLS CUI [1])
Sexually active | Females & males of reproductive potential | Agreement Contraceptive methods
Item
agreement to use contraception during the study and for 30 days after the last dose of study drugs if sexually active and able to bear or beget children.
boolean
C0241028 (UMLS CUI [1])
C4034483 (UMLS CUI [2])
C0680240 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
Life threatening illness | Medical condition | Organ dysfunction | Patient safety At risk | Interferes with absorption ACP-196 | Interferes with metabolic aspects ACP-196 | Risk research results
Item
a life-threatening illness, medical condition or organ system dysfunction which, in the investigator's opinion, could compromise the subject's safety, interfere with the absorption or metabolism of acp-196, or put the study outcomes at undue risk
boolean
C3846017 (UMLS CUI [1])
C1699700 (UMLS CUI [2])
C0349410 (UMLS CUI [3])
C1113679 (UMLS CUI [4,1])
C1444641 (UMLS CUI [4,2])
C0521102 (UMLS CUI [5,1])
C0678745 (UMLS CUI [5,2])
C3827171 (UMLS CUI [5,3])
C0521102 (UMLS CUI [6,1])
C0025520 (UMLS CUI [6,2])
C3827171 (UMLS CUI [6,3])
C0035647 (UMLS CUI [7,1])
C0683954 (UMLS CUI [7,2])
Cardiovascular Diseases | Cardiac Arrhythmia Uncontrolled | ARRHYTHMIA SYMPTOMATIC | Congestive heart failure | Myocardial Infarction | New York Heart Association Classification
Item
significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias, congestive heart failure, or myocardial infarction within 6 months of screening, or any class 3 or 4 cardiac disease as defined by the new york heart association functional classification
boolean
C0007222 (UMLS CUI [1])
C0003811 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
C0741212 (UMLS CUI [3])
C0018802 (UMLS CUI [4])
C0027051 (UMLS CUI [5])
C1275491 (UMLS CUI [6])
Malabsorption Syndrome | Disease Affecting gastrointestinal function | Gastric Bypass | Excision Stomach | Small intestine excision | Inflammatory Bowel Diseases Symptomatic | Partial bowel obstruction | Intestinal Obstruction Complete
Item
malabsorption syndrome, disease significantly affecting gastrointestinal function, gastric bypass, resection of the stomach or small bowel, symptomatic inflammatory bowel disease, or partial or complete bowel obstruction.
boolean
C0024523 (UMLS CUI [1])
C0012634 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C0516983 (UMLS CUI [2,3])
C0017125 (UMLS CUI [3])
C0728940 (UMLS CUI [4,1])
C0038351 (UMLS CUI [4,2])
C0192601 (UMLS CUI [5])
C0021390 (UMLS CUI [6,1])
C0231220 (UMLS CUI [6,2])
C1328480 (UMLS CUI [7])
C0021843 (UMLS CUI [8,1])
C0205197 (UMLS CUI [8,2])
Pregnancy | Breast Feeding
Item
breast feeding or pregnant
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])