metastatic breast cancer
Item
histologically confirmed metastatic breast cancer overexpressing her2
boolean
C1960398 (UMLS CUI [1,1])
C0027627 (UMLS CUI [1,2])
anthracycline
Item
pretreatment with anthracycline in either the adjuvant or palliative setting.
boolean
C0003234 (UMLS CUI [1])
her2 positivity
Item
her2 positivity was defined as 2+ or 3+ overexpression using the dako herceptest, confirmed by fluorescence in-situ hybridization (fish) if 2+.
boolean
C4031572 (UMLS CUI [1])
informed consent
Item
informed consent
boolean
C0021430 (UMLS CUI [1])
chemotherapy
Item
more than 1 chemotherapy for advanced disease
boolean
C0392920 (UMLS CUI [1])
taxane or trastuzumab
Item
taxane or trastuzumab pretreatment
boolean
C0215136 (UMLS CUI [1])
C0728747 (UMLS CUI [2])
brain metastases
Item
brain metastases
boolean
C0220650 (UMLS CUI [1])
performance status
Item
eastern cooperative oncology group (ecog) performance status >1
boolean
C1520224 (UMLS CUI [1])
pregnancy or lactation
Item
pregnancy or lactation, childbearing potential without reliable contraception
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
cardiac disease
Item
clinically significant cardiac disease,
boolean
C0018799 (UMLS CUI [1])
neutrophils platelets
Item
neutrophils <1500/µl, platelets <75,000/µl
boolean
C0948762 (UMLS CUI [1])
C0005821 (UMLS CUI [2])
total bilirubin and creatinine
Item
total bilirubin and creatinine >1.5 × the upper limit of normal
boolean
C0201913 (UMLS CUI [1])
C0201976 (UMLS CUI [2])