Leukemia, Myelocytic, Acute | WHO tumor classification
Item
1. diagnosis of aml (who classification definition of > or = to 20% blasts)
boolean
C0023467 (UMLS CUI [1])
C1301142 (UMLS CUI [2])
recurrent adult acute myeloid leukemia | Leukemia, Myelocytic, Acute Unresponsive to Treatment | Leukemia, Myelocytic, Acute Progressive | Myeloproliferative disease | Myeloproliferative disease Blast Phase | MYELODYSPLASTIC SYNDROME | Apheresis | Hydrea | ruxolitinib
Item
2. in the phase i portion of the study all patients with relapsed or refractory aml are eligible. for the phase ii portion of the study, patients must have aml progressing from prior mpn (mpn-bp) or have mds/mpn with more than 20% blasts. temporary prior measures to control blood counts, such as apheresis or hydrea are allowed. patients with newly diagnosed or previously treated disease are eligible as long as prior therapy does not include hypomethylating agents. prior therapy for ruxolitinib for mpn is allowed.
boolean
C0278780 (UMLS CUI [1])
C0023467 (UMLS CUI [2,1])
C0205269 (UMLS CUI [2,2])
C0023467 (UMLS CUI [3,1])
C0205329 (UMLS CUI [3,2])
C0027022 (UMLS CUI [4])
C0027022 (UMLS CUI [5,1])
C0005699 (UMLS CUI [5,2])
C3463824 (UMLS CUI [6])
C0005791 (UMLS CUI [7])
C0591617 (UMLS CUI [8])
C4054751 (UMLS CUI [9])
C2931926 (UMLS CUI [10])
leukemia | Creatinine measurement | Bilirubin, total measurement | Hemolysis | Congenital Disorders | Alanine aminotransferase measurement
Item
3. serum biochemical values with the following limits unless considered due to leukemia:--- creatinine < or= to 1.5mg/dl ---- total bilirubin < or = to 1.5 mg/dl, unless increase is due to hemolysis or congenital disorder ---- transaminases (sg pt) < or = to 2.5x uln
boolean
C0023418 (UMLS CUI [1])
C0201975 (UMLS CUI [2])
C0201913 (UMLS CUI [3])
C0019054 (UMLS CUI [4])
C0242354 (UMLS CUI [5])
C0201836 (UMLS CUI [6])
Able to swallow oral medication
Item
4. ability to take oral medication.
boolean
C2712086 (UMLS CUI [1,1])
C0175795 (UMLS CUI [1,2])
Informed Consent
Item
5. ability to understand and provide signed informed consent.
boolean
C0021430 (UMLS CUI [1])
performance status
Item
6. performance status < or = to 3, unless directly related to disease process as determined by the principal investigator.
boolean
C1518965 (UMLS CUI [1])
Age
Item
7. age > or = 18 years
boolean
C0001779 (UMLS CUI [1])
Comorbidity Interferes with Study Protocol | Recurrent infections Uncontrolled | Heart Diseases Uncontrolled | Organ dysfunction syndrome | Tuberculosis | HIV | Hepatitis B | Hepatitis C
Item
1. any coexisting medical condition that in the judgment of the treating physician is likely to interfere with study procedures or results including uncontrolled severe infections, as well as uncontrolled cardiac disease, or other organ dysfunction. patients with history of tuberculosis, hiv or hepatitis b and c are excluded.
boolean
C0009488 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C2348563 (UMLS CUI [1,3])
C0239998 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
C0018799 (UMLS CUI [3,1])
C0205318 (UMLS CUI [3,2])
C0342953 (UMLS CUI [4])
C0041296 (UMLS CUI [5])
C0019682 (UMLS CUI [6])
C0019163 (UMLS CUI [7])
C0019196 (UMLS CUI [8])
Breast Feeding | Childbearing Potential Pregnant - blood test confirms | Childbearing Potential Contraceptive methods Unwilling | Contraceptives, Oral | Intrauterine Devices | Vaginal contraceptive diaphragm | Sexual Abstinence | Condom Partner in relationship
Item
2. nursing women, women of childbearing potential with positive blood pregnancy test within 30 days of study start, or women of childbearing potential who are not willing to maintain adequate contraception (such as birth control pills, iud, diaphragm, abstinence, or condoms by their partner) over the entire course of the study.
boolean
C0006147 (UMLS CUI [1])
C3831118 (UMLS CUI [2,1])
C0425986 (UMLS CUI [2,2])
C3831118 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
C0558080 (UMLS CUI [3,3])
C0009905 (UMLS CUI [4])
C0021900 (UMLS CUI [5])
C0042241 (UMLS CUI [6])
C0036899 (UMLS CUI [7])
C0009653 (UMLS CUI [8,1])
C0682323 (UMLS CUI [8,2])
history of prior surgery | Recovery Incomplete | Vascular Access Device Placement
Item
3. incomplete recovery from any prior surgical procedures or had surgery within 4 weeks prior to study entry, excluding the placement of vascular access.
boolean
C0744961 (UMLS CUI [1])
C2004454 (UMLS CUI [2,1])
C0205257 (UMLS CUI [2,2])
C1519955 (UMLS CUI [3])
Communicable Diseases Serious Uncontrolled
Item
4. active clinically serious and uncontrolled infection.
boolean
C0009450 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])