Age
Item
greater than 18 and less than 80 years of age;
boolean
C0001779 (UMLS CUI [1])
Pharmaceutical Preparations Stable status
Item
on stable medication regimen
boolean
C0013227 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
Antihypertensive Agents | Diuretics | Change of medication
Item
o full-tolerated doses of 3 or more anti-hypertensive medications of different classes, one of which must be a diuretic (with no changes for a minimum of two weeks prior to screening) that is expected to be maintained without changes for at least 6-9 months.
boolean
C0003364 (UMLS CUI [1])
C0012798 (UMLS CUI [2])
C0580105 (UMLS CUI [3])
Systolic Pressure Office | blood pressure reading
Item
office systolic blood pressure (sbp) of greater than 160 mmhg based on an average of 3 blood pressure readings measured at both initial screening visit
boolean
C0871470 (UMLS CUI [1,1])
C0442603 (UMLS CUI [1,2])
C0436781 (UMLS CUI [2])
Compliance behavior | Study Protocol
Item
the individual agrees to have all study procedures performed
boolean
C1321605 (UMLS CUI [1])
C2348563 (UMLS CUI [2])
Informed consent
Item
willing to provide written consent
boolean
C0021430 (UMLS CUI [1])
Childbearing Potential | Not pregnant
Item
females with childbearing potential must not be pregnant.
boolean
C3831118 (UMLS CUI [1])
C0232973 (UMLS CUI [2])
Exclusion Criteria
Item
exclusion
boolean
C0680251 (UMLS CUI [1])
renal function GFR estimation by MDRD
Item
egfr of < 45 ml/min/1.73m2, using the mdrd calculation.
boolean
C2170215 (UMLS CUI [1])
Hypertension Adverse Event Hospitalization
Item
more than one in-patient hospitalization for an anti-hypertensive crisis within the year.
boolean
C1963138 (UMLS CUI [1,1])
C0019993 (UMLS CUI [1,2])
Orthostatic Hypotension Episode | Systolic Pressure | Diastolic blood pressure
Item
more than one episode(s) of orthostatic hypotension (reduction of sbp of ≥ 20 mmhg of diastolic blood pressure (dbp) of ≥ 10 mmhg within 3 minutes of standing).
boolean
C0020651 (UMLS CUI [1,1])
C0332189 (UMLS CUI [1,2])
C0871470 (UMLS CUI [2])
C0428883 (UMLS CUI [3])
Myocardial Infarction | Angina, Unstable | Syncope, Cardiogenic | Accident; cardiovascular
Item
history of myocardial infarction (mi), unstable angina pectoris, syncope or a cardiovascular accident within 6 months of screening period
boolean
C0027051 (UMLS CUI [1])
C0002965 (UMLS CUI [2])
C0751535 (UMLS CUI [3])
C1386002 (UMLS CUI [4])
Atrioventricular conduction disturbances | Cardiac Arrhythmia | Atrioventricular Block
Item
clinically significant atrioventricular (av) conduction disturbances and/or arrhythmias (e.g. 2nd or 3rd degree av block);
boolean
C1834655 (UMLS CUI [1])
C0003811 (UMLS CUI [2])
C0004245 (UMLS CUI [3])
Heart failure | Left ventricular ejection fraction
Item
current of past history of heart failure (≤40% left ventricular ejection fraction (ef).
boolean
C0018801 (UMLS CUI [1])
C0428772 (UMLS CUI [2])
Psychotropic Drugs Major | Antidepressive Agents Major
Item
major of psychotropic agents and antidepressants.
boolean
C0033978 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
C0003289 (UMLS CUI [2,1])
C0205164 (UMLS CUI [2,2])
Anti-Inflammatory Agents, Non-Steroidal
Item
use of nonsteroidal anti-inflammatory drug (nsaids)
boolean
C0003211 (UMLS CUI [1])
Hypersensitivity Minocycline | Hypersensitivity Tetracycline | Medical contraindication Minocycline Tetracycline
Item
known hypersensitivity or contraindication to minocycline or other tetracycline.
boolean
C0020517 (UMLS CUI [1,1])
C0026187 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0039644 (UMLS CUI [2,2])
C1301624 (UMLS CUI [3,1])
C0026187 (UMLS CUI [3,2])
C0039644 (UMLS CUI [3,3])
Smoking
Item
smoking
boolean
C0037369 (UMLS CUI [1])
Comorbidity Severe | Neoplasms | HIV Seropositivity | Acquired Immunodeficiency Syndrome
Item
concurrent severe disease (such as neoplasm or hiv positive or aids).
boolean
C0009488 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0027651 (UMLS CUI [2])
C0019699 (UMLS CUI [3])
C0001175 (UMLS CUI [4])