Informed Consent
Item
1. provision of informed consent prior to any study specific procedures
boolean
C0021430 (UMLS CUI [1])
Ethnic group Chinese
Item
2. a patient who is considered as ethnic chinese
boolean
C0015031 (UMLS CUI [1,1])
C0152035 (UMLS CUI [1,2])
Age
Item
3. 80years >aged> 18years, male or female
boolean
C0001779 (UMLS CUI [1])
Coronary revascularisation | Multi vessel coronary artery disease | Anterior descending branch of left coronary artery | Percutaneous Coronary Intervention | Chronic total occlusion of coronary artery | Arterial tortuosity | Diffuse Lesion | Left main coronary artery disease | Drug-Eluting Coronary Stents | Coronary Artery Bypass Surgery | Single organ dysfunction | Aorta; stenosis, calcified
Item
4. patient is willing to perform hcr with the following conditions: multi-vessel coronary artery disease with unfavorable lad for pci (i.e., chronic total occlusion, excessive tortuosity, severely diffuse lesion), unprotected left main coronary artery disease, and non-lad lesions were technically feasible for pci with a drug-eluting stent (des) .limitations to traditional cabg, such as pre-existing organ dysfunction, heavily calcified proximal aorta, or lack of suitable graft conduits
boolean
C0877341 (UMLS CUI [1])
C1299432 (UMLS CUI [2])
C0226032 (UMLS CUI [3])
C1532338 (UMLS CUI [4])
C1955779 (UMLS CUI [5])
C3279191 (UMLS CUI [6])
C1707743 (UMLS CUI [7])
C1299433 (UMLS CUI [8])
C1262327 (UMLS CUI [9])
C0010055 (UMLS CUI [10])
C0349410 (UMLS CUI [11])
C1388213 (UMLS CUI [12])
Involvement with Clinical Trial
Item
1. involvement in the planning and/or conduct of the study
boolean
C1314939 (UMLS CUI [1,1])
C0008976 (UMLS CUI [1,2])
Enrollment in clinical trial Previous | Randomization Previous
Item
2. previous enrolment or randomization in the present study
boolean
C4041024 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C0034656 (UMLS CUI [2,1])
C0205156 (UMLS CUI [2,2])
Study Subject Participation Status | Investigational New Drugs
Item
3. participation in another clinical study with an investigational product during the last 30 days
boolean
C2348568 (UMLS CUI [1])
C0013230 (UMLS CUI [2])
Clopidogrel contraindicated | Medical contraindication Ticagrelor | Hypersensitivity | Hemorrhage | Has Moderate or Severe Liver Disease | Intracranial Hemorrhages | Gastrointestinal Hemorrhage | Major surgery
Item
4. contraindication or other reason that clopidogrel or ticagrelor should not be administered (eg, hypersensitivity, active bleeding, moderate or severe liver disease, history of previous intracranial bleed, gi bleed within the past 6 months, major surgery within 30 days)
boolean
C1319916 (UMLS CUI [1])
C1301624 (UMLS CUI [2,1])
C1999375 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3])
C0019080 (UMLS CUI [4])
C3829821 (UMLS CUI [5])
C0151699 (UMLS CUI [6])
C0017181 (UMLS CUI [7])
C0679637 (UMLS CUI [8])
Blood Coagulation Disorders
Item
5. with coagulation disorder
boolean
C0005779 (UMLS CUI [1])
Uric acid nephropathy acute
Item
6. with uric acid nephropathy
boolean
C0859034 (UMLS CUI [1])
Intolerance Aspirin | Intolerance Clopidogrel | Intolerance Ticagrelor | Hypersensitivity Aspirin | Hypersensitivity clopidogrel | Hypersensitivity Ticagrelor
Item
7. history of intolerance or allergy to asa or clopidogrel or ticagrelor
boolean
C1744706 (UMLS CUI [1,1])
C0004057 (UMLS CUI [1,2])
C1744706 (UMLS CUI [2,1])
C0070166 (UMLS CUI [2,2])
C1744706 (UMLS CUI [3,1])
C1999375 (UMLS CUI [3,2])
C0020517 (UMLS CUI [4,1])
C0004057 (UMLS CUI [4,2])
C0020517 (UMLS CUI [5,1])
C0070166 (UMLS CUI [5,2])
C0020517 (UMLS CUI [6,1])
C1999375 (UMLS CUI [6,2])
Coronary Artery Bypass Surgery
Item
8. patient has a coronary artery bypass graft (cabg) history.
boolean
C0010055 (UMLS CUI [1])
Stenosis of left subclavian artery | Left internal mammary artery Stenosis
Item
9. left subclavian artery and lima stenosis
boolean
C4047831 (UMLS CUI [1])
C0447054 (UMLS CUI [2,1])
C1261287 (UMLS CUI [2,2])
Anterior descending branch of left coronary artery | Myocardium
Item
10. buried intramyocardial lad
boolean
C0226032 (UMLS CUI [1])
C0027061 (UMLS CUI [2])
Needs Operative Surgical Procedures Simultaneous | Repair of heart valve | Heart valve replacement
Item
11. need for a concomitant operation (e.g., valve repair or replacement)
boolean
C0027552 (UMLS CUI [1,1])
C0543467 (UMLS CUI [1,2])
C0521115 (UMLS CUI [1,3])
C0190112 (UMLS CUI [2])
C0190173 (UMLS CUI [3])
Congestive heart failure
Item
12. overt congestive heart failure
boolean
C0018802 (UMLS CUI [1])
Left internal mammary artery Anterior descending branch of left coronary artery Graft Unsuccessful
Item
13. unsuccessful lima-lad graft
boolean
C0447054 (UMLS CUI [1,1])
C0226032 (UMLS CUI [1,2])
C0332835 (UMLS CUI [1,3])
C1272705 (UMLS CUI [1,4])
Hemodynamic instability
Item
14. hemodynamic instability
boolean
C0948268 (UMLS CUI [1])
Percutaneous Coronary Intervention Patient unsuitable for procedure due to medical condition | Thrombus Fresh | Coronary Vessel Diameter
Item
15. other conditions rendering pci unsuitable (e.g., fresh thrombus, coronary vessel diameter <1.5 mm)
boolean
C1532338 (UMLS CUI [1,1])
C3839545 (UMLS CUI [1,2])
C0087086 (UMLS CUI [2,1])
C0443224 (UMLS CUI [2,2])
C0010075 (UMLS CUI [3,1])
C1301886 (UMLS CUI [3,2])
Platelet Count measurement
Item
16. platelet count less than 100*10^9/l
boolean
C0032181 (UMLS CUI [1])
Hemoglobin level
Item
17. haemoglobin (hb) level less than 110g/l
boolean
C0019029 (UMLS CUI [1])
White Blood Cell Count procedure
Item
18. white blood cell count less than 4*10^12/l
boolean
C0023508 (UMLS CUI [1])
Blood Donation Recent
Item
19. recent (within 30 days of dosing) blood donation
boolean
C0005794 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
Thrombolytic Therapy | ST segment elevation myocardial infarction | Pulmonary Embolism
Item
20. fibrinolytic therapy in the 24 hours prior to randomisation, or planned fibrinolytic treatment following randomisation (eg, for stemi or pulmonary embolism)
boolean
C0040044 (UMLS CUI [1])
C1536220 (UMLS CUI [2])
C0034065 (UMLS CUI [3])
P2Y12 Receptor Antagonists Therapeutic procedure
Item
21. p2y12 receptor inhibitor therapy in 7 days before hcr surgery.
boolean
C2962193 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
Anti-Inflammatory Agents, Non-Steroidal | Prostaglandins I | Epoprostenol | Therapeutic procedure
Item
22. nonselective non-steroidal anti-inflammatory drugs (nsaids) and prostacyclins (pgi2) therapy that cannot be stopped
boolean
C0003211 (UMLS CUI [1])
C0205911 (UMLS CUI [2])
C0033567 (UMLS CUI [3])
C0087111 (UMLS CUI [4])
At risk of bradycardia | Artificial cardiac pacemaker | Sick Sinus Syndrome | Second degree atrioventricular block | Complete atrioventricular block | Syncope Due to Bradycardia
Item
23. increased risk of bradycardic events (eg, no pacemaker and known sick sinus syndrome, second degree av block, third degree av block or previous documented syncope suspected to be due to bradycardia).
boolean
C3875145 (UMLS CUI [1])
C0030163 (UMLS CUI [2])
C0037052 (UMLS CUI [3])
C0264906 (UMLS CUI [4])
C0151517 (UMLS CUI [5])
C0039070 (UMLS CUI [6,1])
C0678226 (UMLS CUI [6,2])
C0428977 (UMLS CUI [6,3])
Concomitant Therapy Oral Route of Drug administration | Concomitant Therapy Intravenous Route of Drug Administration | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP3A Inducers
Item
24. concomitant oral or intravenous therapy (see examples below) with strong cyp3a inhibitors, cyp3a substrates with narrow therapeutic indices, or strong cyp3a inducers within 14 days of study treatment or cannot be stopped for the course of the study.
boolean
C1707479 (UMLS CUI [1,1])
C1527415 (UMLS CUI [1,2])
C1707479 (UMLS CUI [2,1])
C1522726 (UMLS CUI [2,2])
C3850056 (UMLS CUI [3])
C3850044 (UMLS CUI [4])
inhibitors | Ketoconazole | Itraconazole | voriconazole | telithromycin | Clarithromycin | Nefadar | Ritonavir | Saquinavir | Nelfinavir | Indinavir | Reyataz | GRAPEFRUIT JUICE
Item
strong inhibitors: ketoconazole, itraconazole, voriconazole, telithromycin, clarithromycin, nefazadone, ritonavir, saquinavir, nelfinavir, indinavir, atanazavir, over 1 litre daily of grapefruit juice.
boolean
C0243077 (UMLS CUI [1])
C0022625 (UMLS CUI [2])
C0064113 (UMLS CUI [3])
C0393080 (UMLS CUI [4])
C0907410 (UMLS CUI [5])
C0055856 (UMLS CUI [6])
C1436233 (UMLS CUI [7])
C0292818 (UMLS CUI [8])
C0286738 (UMLS CUI [9])
C0525005 (UMLS CUI [10])
C0376637 (UMLS CUI [11])
C1258207 (UMLS CUI [12])
C0452456 (UMLS CUI [13])
Substrate Narrow Therapeutic Index | Cyclosporine | Quinidine | Rifampin | Phenytoin | Carbamazepine
Item
substrates with narrow therapeutic index: cyclosporine, quinidine. strong inducers: rifampin/rifampicin, phenytoin, carbamazepine. the sponsor should be consulted for enrolment with any concomitant medicines which are suspected of undergoing strong drug-drug interaction
boolean
C3891814 (UMLS CUI [1,1])
C3889681 (UMLS CUI [1,2])
C0010592 (UMLS CUI [2])
C0034414 (UMLS CUI [3])
C0035608 (UMLS CUI [4])
C0031507 (UMLS CUI [5])
C0006949 (UMLS CUI [6])
Comorbidity Affecting Patient safety Research results | Shock, Cardiogenic | Malignant Neoplasms
Item
25. any other condition which in the opinion of the investigator, may either put the patient at risk or influence the result of the study (e.g., cardiogenic shock or active cancer)
boolean
C0009488 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C1113679 (UMLS CUI [1,3])
C0683954 (UMLS CUI [1,4])
C0036980 (UMLS CUI [2])
C0006826 (UMLS CUI [3])
Has Moderate or Severe Renal Disease
Item
26. moderate or severe renal disease;
boolean
C3829820 (UMLS CUI [1])
Chronic lung disease Moderate | Severe chronic lung disease | Moderate asthma | Severe asthma
Item
27. moderate or severe chronic lung disease or asthma;
boolean
C0746102 (UMLS CUI [1,1])
C0205081 (UMLS CUI [1,2])
C3278799 (UMLS CUI [2])
C0581125 (UMLS CUI [3])
C0581126 (UMLS CUI [4])
Pregnancy | Breast Feeding
Item
28. pregnancy or lactation
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])