Invasive breast carcinoma Operable
Item
newly diagnosed histologically or cytologically confirmed operable invasive breast cancer defined as ct1 or t2, n0-1, and m0.
boolean
C0853879 (UMLS CUI [1,1])
C0205188 (UMLS CUI [1,2])
Disease Estrogen receptor positive Human epidermal growth factor 2 negative carcinoma of breast | Allred score
Item
disease must be er+ (allred score ≥ 5) and her2-.
boolean
C0012634 (UMLS CUI [1,1])
C0279754 (UMLS CUI [1,2])
C2316304 (UMLS CUI [1,3])
C2919519 (UMLS CUI [2])
Measurable Disease | Lesion | Ultrasonics (sound) | Mammography
Item
measurable disease defined as lesions that can be accurately measured in at least one dimension (longest diameter to be recorded) by ultrasound or mammogram.
boolean
C1513041 (UMLS CUI [1])
C0221198 (UMLS CUI [2])
C1456803 (UMLS CUI [3])
C0024671 (UMLS CUI [4])
Age
Item
75 years of age or older.
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
ecog performance status ≤ 2
boolean
C1520224 (UMLS CUI [1])
Comprehension Informed Consent Institutional Review Board Approval
Item
able to understand and willing to sign an irb approved written informed consent document (or that of legally authorized representative, if applicable).
boolean
C0162340 (UMLS CUI [1,1])
C0021430 (UMLS CUI [1,2])
C2346499 (UMLS CUI [1,3])
Prior Chemotherapy Malignant Neoplasms | Prior Hormone Therapy Malignant Neoplasms
Item
prior chemotherapy and/or hormone therapy for cancer.
boolean
C1514457 (UMLS CUI [1,1])
C0006826 (UMLS CUI [1,2])
C1514460 (UMLS CUI [2,1])
C0006826 (UMLS CUI [2,2])
Malignant Neoplasms | Hormone Therapy
Item
a history of other malignancy ≤ 5 years previous which would preclude endocrine treatment of their cancer.
boolean
C0006826 (UMLS CUI [1])
C0279025 (UMLS CUI [2])
Investigational New Drugs Other
Item
currently receiving any other investigational agents.
boolean
C0013230 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
Allergic Reaction Investigational New Drugs Compound (substance)
Item
a history of allergic reactions attributed to compounds of similar chemical or biologic composition to any of the agents used in the study.
boolean
C1527304 (UMLS CUI [1,1])
C0013230 (UMLS CUI [1,2])
C1706082 (UMLS CUI [1,3])
Disease Uncontrolled | Compliance behavior Limited
Item
uncontrolled intercurrent illness as determined by their treating physician which would limit compliance with study requirements.
boolean
C0012634 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C1321605 (UMLS CUI [2,1])
C0439801 (UMLS CUI [2,2])
HIV Seropositivity | Antiretroviral therapy | Pharmacokinetic interaction Hormone Therapy
Item
known hiv-positivity on combination antiretroviral therapy because of the potential for pharmacokinetic interactions with endocrine therapies. appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated.
boolean
C0019699 (UMLS CUI [1])
C1963724 (UMLS CUI [2])
C1868980 (UMLS CUI [3,1])
C0279025 (UMLS CUI [3,2])