Asthma
Item
inclusion criteria male or female subject with confirmed asthma, and
boolean
C0004096 (UMLS CUI [1])
Age
Item
age ≥ 18 years
boolean
C0001779 (UMLS CUI [1])
Asthma control test score
Item
asthma control test (act) score of 15-20, and
boolean
C2733224 (UMLS CUI [1])
Atopy | Skin prick test
Item
documented atopy by prick skin testing (most study participants will likely have participated in one of the investigators prior observational studies and will have had skin testing, if not, this will be performed at an in-person screening visit), and
boolean
C0392707 (UMLS CUI [1])
C0430561 (UMLS CUI [2])
Pregnant | Contraceptive methods
Item
for women: not pregnant, as determined by a negative urinary pregnancy test at the initial visit(visit 1), and at the start of the cross-over period (visit 4), and using birth control
boolean
C0032961 (UMLS CUI [1])
C0700589 (UMLS CUI [2])
Hypersensitivity Asteraceae | Cirsium | Bellis | Cynara scolymus | Actinidia
Item
known allergies to plants in the asteraceae family (thistles, daisies, artichokes, kiwi)
boolean
C0020517 (UMLS CUI [1,1])
C0446228 (UMLS CUI [1,2])
C1009560 (UMLS CUI [2])
C1009534 (UMLS CUI [3])
C1021820 (UMLS CUI [4])
C0949891 (UMLS CUI [5])
Not Asthma | No signs/symptoms Asthma | No confirmation of Asthma
Item
non-asthmatic, or inadequate documentation which includes lack of signs and symptoms of asthma, or lack of prior confirmatory testing
boolean
C1518422 (UMLS CUI [1,1])
C0004096 (UMLS CUI [1,2])
C3846032 (UMLS CUI [2,1])
C0004096 (UMLS CUI [2,2])
C0521092 (UMLS CUI [3,1])
C0004096 (UMLS CUI [3,2])
Patient currently pregnant
Item
pregnant
boolean
C0032961 (UMLS CUI [1])
Age
Item
age < 18 years
boolean
C0001779 (UMLS CUI [1])
English speaking
Item
non-english speaking
boolean
C0376245 (UMLS CUI [1])
Current Smoker
Item
current smoker (current, or within last year)
boolean
C3241966 (UMLS CUI [1])
Chronic Obstructive Airway Disease
Item
chronic obstructive pulmonary disease(copd)
boolean
C0024117 (UMLS CUI [1])
Swallowing problem capsule
Item
unable to swallow capsules
boolean
C0392678 (UMLS CUI [1,1])
C0006935 (UMLS CUI [1,2])
Unable Informed Consent
Item
unable to obtain informed consent
boolean
C0021430 (UMLS CUI [1])
Compliance behavior Limited | silybin | plasma concentration Measurement
Item
unable to comply with avoidance of honey and propolis containing foods (which interfere with the silybin assays for measurement of plasma concentrations)
boolean
C1321605 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C0600334 (UMLS CUI [2])
C0683150 (UMLS CUI [3,1])
C0242485 (UMLS CUI [3,2])