alzheimers disease; NINCDS-ADRDA Criteria
Item
diagnosis of probable alzheimer disease according to the national institute of neurological and communicative disorders and stroke-alzheimer's diseases and related disorders association (nincds-adrda) criteria.
boolean
C0002395 (UMLS CUI [1])
C2828081 (UMLS CUI [2])
mini-mental state examination
Item
mini-mental state examination (mmse) score of 12 to 24 at screening
boolean
C0451306 (UMLS CUI [1])
Modified Hachinski Ischemic Scale
Item
rosen modified hachinski ischemic score < or equal to 4 at screening.
boolean
C3826978 (UMLS CUI [1])
neurologic disease
Item
relevant neurologic disease other than alzheimer disease that may affect cognition or ability to complete the study.
boolean
C0027765 (UMLS CUI [1])
depressive disorder; psychiatric disorder
Item
current major depressive disorder or other current major psychiatric disorder.
boolean
C0011581 (UMLS CUI [1])
C0004936 (UMLS CUI [2])
stroke; Carotid Stenosis; vertebrobasilar stenosis; plaque
Item
history of clinically evident stroke or clinically important carotid or vertebrobasilar stenosis or plaque.
boolean
C0038454 (UMLS CUI [1])
C0007282 (UMLS CUI [2])
C0149810 (UMLS CUI [3])
C0332461 (UMLS CUI [4])
memantine; Ginkgo biloba; huperzine a; cholinesterase inhibitors
Item
use of prescription or nonprescription medications for cognitive enhancement (including memantine, ginkgo biloba, huperzine a, and cholinesterase inhibitors) within 3 months before the baseline visit.
boolean
C0025242 (UMLS CUI [1])
C0330206 (UMLS CUI [2])
C0063033 (UMLS CUI [3])
C0008425 (UMLS CUI [4])