all or non-hodgkin-lymphoma
Item
proven diagnosis of all or very aggressive non-hodgkin-lymphoma (burkitt/burkitt-like) and cns relapse
boolean
C0023449 (UMLS CUI [1])
C0006413 (UMLS CUI [2])
cns involvement
Item
cns involvement demonstrated by a positive ventricular or lumbar csf cytology or characteristic signs and symptoms of neoplastic meningitis plus an mri or ct scan indicating the presence of meningeal involvement
boolean
C0449389 (UMLS CUI [1])
systemic therapy
Item
in combined relapse in cns and other locations: systemic therapy with cns active drugs can be postponed for at least 2 weeks
boolean
C1515119 (UMLS CUI [1])
karnofsky performance score
Item
karnofsky performance score is > or = 60%
boolean
C0206065 (UMLS CUI [1])
Age
Item
18 years of age or older
boolean
C0001779 (UMLS CUI [1])
Communicable Diseases
Item
free of uncontrolled infection
boolean
C0009450 (UMLS CUI [1])
Drug toxicity
Item
recovered from any grade iii / iv toxicities attributable to prior treatment with the exception of hematotoxicity
boolean
C0013221 (UMLS CUI [1])
Not pregnant or breast feeding
Item
patient not pregnant or breast feeding and effective methods to prevent pregnancy
boolean
C3242212 (UMLS CUI [1])
C0700589 (UMLS CUI [2])
Multiple Organ Failure
Item
free from severe heart, lung, liver or kidney dysfunction
boolean
C0026766 (UMLS CUI [1])
written informed consent
Item
written informed consent
boolean
C0021430 (UMLS CUI [1])
Methotrexate
Item
failed to respond (as defined by no clearance of the csf) to > 1 dose of prior i.th. mtx or arac or triple therapy
boolean
C0025677 (UMLS CUI [1])
Neurotoxicity Syndromes
Item
history of neurotoxicity (grade iii - iv) attributed to i.th. or systemic hd therapy with mtx or arac
boolean
C0235032 (UMLS CUI [1])
cns relapse
Item
prior cns relapse < 1 month before
boolean
C3714787 (UMLS CUI [1,1])
C0035020 (UMLS CUI [1,2])