Acute lymphocytic leukemia
Item
diagnosis of acute lymphoblastic leukemia (pro b, pre b, c-all or t-all), proved by morphology and immunophenotyping
boolean
C0023449 (UMLS CUI [1])
Age
Item
age > 55 yrs (no upper age limit)
boolean
C0001779 (UMLS CUI [1])
written informed consent
Item
written informed consent
boolean
C0021430 (UMLS CUI [1])
cancer complication
Item
severe leukemia associated complications, not controllable before therapy onset e.g.
boolean
C0596237 (UMLS CUI [1])
Communicable Diseases
Item
life threatening infections as sepsis, pneumonia, hypoxia, shock, life threatening bleeding)
boolean
C0009450 (UMLS CUI [1])
Kidney Failure
Item
decompensated renal failure if not caused by leukemia with creatinine > 2x uln
boolean
C0035078 (UMLS CUI [1])
Heart failure
Item
heart failure (nyha ii/iv), instable angina, significant coronary stenosis
boolean
C0018801 (UMLS CUI [1])
Hepatic Insufficiency
Item
hepatic insufficiency e.g. liver cirrhosis or chronic active hepatitis with bilirubin > 1,5 x uln and/or asa, ala, ap > 2,5 uln
boolean
C1306571 (UMLS CUI [1])
metabolic disturbance
Item
decompensated metabolic disturbances (e.g. not controllable diabetes)
boolean
C0746556 (UMLS CUI [1])
Chronic Obstructive Airway Disease or Restrictive pulmonary disease
Item
severe obstructive or restrictive pulmonary disease with hypoxaemia
boolean
C0024117 (UMLS CUI [1])
C0877013 (UMLS CUI [2])
Mental disorders
Item
severe psychiatric illness or other circumstances which may compromise cooperation of the patient
boolean
C0004936 (UMLS CUI [1])
Second Primary Neoplasms
Item
active second neoplasia
boolean
C0085183 (UMLS CUI [1])
HIV Infection
Item
hiv infection
boolean
C0019693 (UMLS CUI [1])
Reduced general condition
Item
severely reduced general condition
boolean
C1112627 (UMLS CUI [1])
Cytostatic chemotherapy
Item
cytostatic pre-treatment of all
boolean
C2609342 (UMLS CUI [1])
Chemotherapy
Item
chemotherapy treatment of any other malignancy during the last 5 years
boolean
C3665472 (UMLS CUI [1])
participation in other clinical trials
Item
participation in other clinical trials interfering with the study therapy
boolean
C2348568 (UMLS CUI [1])