age
Item
subject is an adult between the ages of 18 to 65 years.
boolean
C0001779 (UMLS CUI [1])
asthma, inhaled corticosteroid (ics) and long acting ß2-agonist (laba)
Item
subject has asthma and is taking regular maintenance medication that includes inhaled corticosteroid (ics) and long acting ß2-agonist (laba).
boolean
C0004096 (UMLS CUI [1])
C3248292 (UMLS CUI [2])
C2936789 (UMLS CUI [3,1])
C0040223 (UMLS CUI [3,2])
pre-bronchodilator fev1
Item
subject has a pre-bronchodilator forced expiratory volume in one second (fev1) of greater than or equal to 60% of predicted after medication stabilization during the baseline period.
boolean
C3172227 (UMLS CUI [1])
pc20
Item
subject has a pc20 < 8 mg/ml per methacholine inhalation test using standardized methods. pc20 is a provocative concentration of provocholine® (a brand of methacholine chloride) resulting in a drop of fev1 of 20% or more from baseline.
boolean
C1714620 (UMLS CUI [1])
asthma symptom frequency
Item
subject has at least two days of asthma symptoms during the 4-weeks of the baseline diary period.
boolean
C0004096 (UMLS CUI [1,1])
C1457887 (UMLS CUI [1,2])
C0439603 (UMLS CUI [1,3])
smoking history
Item
subject is a non-smoker for 1 year or greater (if former smoker, less than 10 pack years total smoking history).
boolean
C1519384 (UMLS CUI [1])
C1277691 (UMLS CUI [2])
post-bronchodilator fev1
Item
subject has a post-bronchodilator fev1 of less than 65%.
boolean
C0748133 (UMLS CUI [1,1])
C2599594 (UMLS CUI [1,2])
hospitalizations for exacerbations of asthma
Item
subject has 3 or more hospitalizations for exacerbations of asthma in the previous year; or a history of life-threatening asthma, defined by past intubations for asthma, or icu admission for asthma within the prior 24 months.
boolean
C0019993 (UMLS CUI [1])
C0349790 (UMLS CUI [2])
C0004096 (UMLS CUI [3,1])
C2826244 (UMLS CUI [3,2])
recurrent lower respiratory tract infections
Item
subject has a history of recurrent lower respiratory tract infections requiring antibiotics (more than 3 in the past 12 months).
boolean
C0149725 (UMLS CUI [1,1])
C2945760 (UMLS CUI [1,2])
C1514873 (UMLS CUI [2,1])
C0003232 (UMLS CUI [2,2])
recurrent oral steroid use
Item
subject has a history of recurrent oral steroid use for asthma (4 or more pulses of oral steroids in the past 12 months).
boolean
C0574135 (UMLS CUI [1,1])
C2945760 (UMLS CUI [1,2])
sensitivity to medications required to perform bronchoscopy
Item
subject has a known sensitivity to medications required to perform bronchoscopy (such as lidocaine, atropine and benzodiazepines).
boolean
C0020517 (UMLS CUI [1,1])
C0023660 (UMLS CUI [1,2])
C0004259 (UMLS CUI [1,3])
C0005064 (UMLS CUI [1,4])
hypersensitivity or contraindication to methacholine chloride or other parasympathomimetic agents
Item
subject has known systemic hypersensitivity or contraindication to methacholine chloride or other parasympathomimetic agents.
boolean
C0020517 (UMLS CUI [1,1])
C0079829 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0030512 (UMLS CUI [2,2])
other medical criteria
Item
subject has other medical criteria.
boolean
C0009488 (UMLS CUI [1])